Table 1 The single polymorphisms of APOA5 gene and the association with obesity and metabolic syndromes

APOA5

-1131 T > C

CAD

Elevated plasma TG

Elevated LDL-TG

Decreased HDL-C

Elevated VLDL-C

Decreased LDL particle size

Elevated TG after fasting

Elevated postprandial TG

Elevated postprandial VLDL

Higher dense postprandial LDL

Elevated postprandial CRP

Elevated total cholesterol

Elevated BMI

Elevated fat intake

Lower obesity risk

c.1259 T > C

Elevated plasma TG

Protective against obesity (alone)

c.56C > G

Higher BMI, waist and hip circumference

Extreme obesity (carried with LPL m107)

Decreased HDL

c.3A > G

Elevated metabolic syndrome risk

c.553G > T

Elevated metabolic syndrome risk

c.724C > G

Elevated plasma TG

IVS3 + 476G > A

Elevated plasma TG