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Table 5 % change of oxidative stress markers during intervention

From: Suppression of DNA/RNA and protein oxidation by dietary supplement which contains plant extracts and vitamins: a randomized, double-blind, placebo-controlled trial

 

Placebo (N = 28)

Supplement (N = 30)

P4–4b

P8–8

PPlc

PSup

% of baseline levels

4 week

8 week

4 week

8 week

  

LagTime (min)a

99.9 ± 17.2

98.9 ± 12.4

96.1 ± 17.1

102.2 ± 19.8

  

Isoprostane (ng/mmol)

102.7 (83.5–136.1)

129.8# (100.2–186.9)

90.3 (58.3–112.1)

79.0 (45.6–122.9)

0.05 0.003

0.005 0.3

oxLDL (μg/mL)

97.1 (89.0 0–104.4)

100.5 (87.7–110.0)

100.3 (91.9–112.5)

101.7 (89.2–112.1)

0.5 0.1

0.2 0.8

TBARS (μΜ)a

107.1 ± 27.4

100.3 ± 25.5

100.0 ± 26.7

104.3 ± 31.8

  

8-hydroxy-2΄-deoxyguanosine (μg/mmol)

96.1 (83.8–128.8)

102.8 (88.9–145.2)

85.2,# (60.9–101.8)

72.3# (45.2–102.6)

0.02 0.000

0.4 0.003

Protein Carbonyls (nmol/mg protein)

112.8 (91.6–120.5)

104.5 (91.5–118.1)

83.3# (71.7–102.3)

81.3# (61.7–100.6)

0.000 0.001

0.3 0.003

Gpx activity (U/mL)

95.8 (87.6–116.7)

94.7 (74.8–115.4)

100.0 (87.6–115.3)

102.9 (88.2–117.5)

0.8 0.1

0.3 0.9

SOD activity (U/mg protein)

106.4 (75.0–160.4)

88.1 (66.7–151).7

63.6# |(42.8–127.4)

71.3 (50.4–126.8)

0.01 0.2

0.7 0.008

  1. Data are presented as means ± SD for normally distributed variables and as median (lower-upper quartile (25th -75th) for skewed variables
  2. aFor normally distributed variables repeated measures ANOVA was used for the comparisons (All p’s > 0.05, result section)
  3. bFor skewed variables Mann-Whitney two independent test was used for the comparison of Supplement vs Palcebo at 4 or 8 weeks
  4. cFriedman’s 2-way ANOVA by ranks was used for the estimation of time effect in placebo or Supplement trial, #P < 0.05 pairwise comparison vs 0 week of Friedman’s 2-way ANOVA by ranks