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Table 1 Meta-analysis between the MTHFR rs1801133 polymorphism and CAD risk

From: Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis

Model Group or subgroup OR 95% CI P heterogeneity P OR
Allelic model
(T vs C)
Total 1.11 1.06–1.17 < 0.01 < 0.01
Studies in HWE 1.11 1.06–1.16 < 0.01 < 0.01
Male 1.04 0.90–1.20 < 0.01 0.59
Female 0.98 0.88–1.08 0.40 0.63
Caucasian 1.03 0.99–1.07 < 0.01 0.10
Asian 1.24 1.11–1.39 < 0.01 < 0.01
African 1.30 0.84–2.00 < 0.01 0.24
Other ethnicity 1.30 0.96–1.76 < 0.01 0.09
Additive model
(TT vs CC)
Total 1.25 1.14–1.37 < 0.01 < 0.01
Studies in HWE 1.23 1.12–1.35 < 0.01 < 0.01
Male 1.22 0.96–1.55 < 0.01 0.10
Female 0.93 0.75–1.16 0.65 0.53
Caucasian 1.08 1.00–1.17 0.03 0.05
Asian 1.46 1.20–1.76 < 0.01 < 0.01
African 1.96 0.84–4.60 < 0.01 0.12
Other ethnicity 1.83 0.93–3.59 < 0.01 0.08
Dominant model
(TT + CT vs CC)
Total 1.11 1.04–1.17 < 0.01 < 0.01
Studies in HWE 1.11 1.05–1.17 < 0.01 < 0.01
Male 1.00 0.80–1.25 < 0.01 0.98
Female 0.98 0.83–1.16 0.20 0.84
Caucasian 1.02 0.97–1.06 0.05 0.45
Asian 1.27 1.08–1.50 < 0.01 < 0.01
African 1.22 0.78–1.92 < 0.01 0.39
Other ethnicity 1.30 0.95–1.77 < 0.01 0.10
Recessive model
(TT vs CT + CC)
Total 1.22 1.12–1.32 < 0.01 < 0.01
Studies in HWE 1.20 1.11–1.30 < 0.01 < 0.01
Female 0.96 0.78–1.17 0.76 0.67
Male 1.21 0.96–1.51 < 0.01 0.10
Caucasian 1.09 1.01–1.17 0.06 0.02
Asian 1.36 1.14–1.62 < 0.01 < 0.01
African 1.90 0.84–4.30 < 0.01 0.13
Other ethnicity 1.71 0.94–3.12 < 0.01 0.08
  1. MTHFR 5,10-methylenetetrahydrofolate reductase gene, CAD coronary artery disease, OR odds ratio, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium