Table 1 Meta-analysis between the MTHFR rs1801133 polymorphism and CAD risk
Model | Group or subgroup | OR | 95% CI | P heterogeneity | P OR |
|---|---|---|---|---|---|
Allelic model (T vs C) | Total | 1.11 | 1.06–1.17 | < 0.01 | < 0.01 |
Studies in HWE | 1.11 | 1.06–1.16 | < 0.01 | < 0.01 | |
Male | 1.04 | 0.90–1.20 | < 0.01 | 0.59 | |
Female | 0.98 | 0.88–1.08 | 0.40 | 0.63 | |
Caucasian | 1.03 | 0.99–1.07 | < 0.01 | 0.10 | |
Asian | 1.24 | 1.11–1.39 | < 0.01 | < 0.01 | |
African | 1.30 | 0.84–2.00 | < 0.01 | 0.24 | |
Other ethnicity | 1.30 | 0.96–1.76 | < 0.01 | 0.09 | |
Additive model (TT vs CC) | Total | 1.25 | 1.14–1.37 | < 0.01 | < 0.01 |
Studies in HWE | 1.23 | 1.12–1.35 | < 0.01 | < 0.01 | |
Male | 1.22 | 0.96–1.55 | < 0.01 | 0.10 | |
Female | 0.93 | 0.75–1.16 | 0.65 | 0.53 | |
Caucasian | 1.08 | 1.00–1.17 | 0.03 | 0.05 | |
Asian | 1.46 | 1.20–1.76 | < 0.01 | < 0.01 | |
African | 1.96 | 0.84–4.60 | < 0.01 | 0.12 | |
Other ethnicity | 1.83 | 0.93–3.59 | < 0.01 | 0.08 | |
Dominant model (TT + CT vs CC) | Total | 1.11 | 1.04–1.17 | < 0.01 | < 0.01 |
Studies in HWE | 1.11 | 1.05–1.17 | < 0.01 | < 0.01 | |
Male | 1.00 | 0.80–1.25 | < 0.01 | 0.98 | |
Female | 0.98 | 0.83–1.16 | 0.20 | 0.84 | |
Caucasian | 1.02 | 0.97–1.06 | 0.05 | 0.45 | |
Asian | 1.27 | 1.08–1.50 | < 0.01 | < 0.01 | |
African | 1.22 | 0.78–1.92 | < 0.01 | 0.39 | |
Other ethnicity | 1.30 | 0.95–1.77 | < 0.01 | 0.10 | |
Recessive model (TT vs CT + CC) | Total | 1.22 | 1.12–1.32 | < 0.01 | < 0.01 |
Studies in HWE | 1.20 | 1.11–1.30 | < 0.01 | < 0.01 | |
Female | 0.96 | 0.78–1.17 | 0.76 | 0.67 | |
Male | 1.21 | 0.96–1.51 | < 0.01 | 0.10 | |
Caucasian | 1.09 | 1.01–1.17 | 0.06 | 0.02 | |
Asian | 1.36 | 1.14–1.62 | < 0.01 | < 0.01 | |
African | 1.90 | 0.84–4.30 | < 0.01 | 0.13 | |
Other ethnicity | 1.71 | 0.94–3.12 | < 0.01 | 0.08 |