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Table 2 Meta-analysis between the MTHFR rs1801133 polymorphism and plasma lipid levels

From: Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis

Group or subgroup

Comparison (Subjects)

SMD (95% CI)

P Heterogeneity

P SMD

TG

 All

62 (39,760)

0.03 (−0.01–0.06)

< 0.01

0.11

 Studies in HWE

46 (34,889)

0.01 (− 0.01–0.03)

0.11

0.44

 Male

4 (2518)

0.00 (− 0.08–0.08)

0.71

0.96

 Female

8 (1589)

0.13 (− 0.07–0.33)

0.01

0.21

 Caucasian

25 (29,136)

0.00 (−0.04–0.04)

0.11

0.93

 Asian

24 (8639)

0.05 (−0.02–0.13)

< 0.01

0.16

 African

2 (191)

0.20 (−0.09–0.48)

0.65

0.18

 Other ethnicity

11 (1794)

0.07 (−0.03–0.17)

0.79

0.15

 CAD

10 (2907)

0.01 (−0.06–0.09)

0.54

0.74

 T2DM

6 (812)

0.07 (−0.14–0.28)

0.09

0.51

 Hypertension

4 (1522)

0.03 (−0.09–0.15)

0.70

0.63

 Healthy or control

17 (26,612)

0.01 (−0.02–0.04)

0.33

0.50

TC

 All

79 (72,848)

0.04 (0.01–0.07)

< 0.01

0.02

 Studies in HWE

57 (51,283)

0.01 (−0.00–0.03)

0.13

0.12

 Male

11 (5067)

0.03 (−0.05–0.11)

0.18

0.52

 Female

15 (28,790)

0.11 (0.02–0.19)

0.01

0.02

 Caucasian

26 (41,744)

0.00 (−0.05–0.04)

0.02

0.95

 Asian

36 (13,385)

0.10 (0.04–0.15)

0.01

< 0.01

 African

3 (277)

−0.32 (−1.24–0.60)

< 0.01

0.49

 Other ethnicity

14 (17,442)

−0.01 (− 0.04–0.02)

0.48

0.55

 CAD

9 (2676)

0.02 (−0.06–0.10)

0.45

0.66

 T2DM

5 (705)

0.03 (−0.20–0.27)

0.09

0.77

 Hypertension

6 (11,288)

−0.02 (− 0.06–0.02)

0.47

0.34

 Healthy or control

31 (49,859)

0.07 (0.02–0.12)

< 0.01

< 0.01

LDL-C

 All

65 (29,424)

0.07 (0.01–0.12)

< 0.01

0.01

 Studies in HWE

45 (13,946)

0.04 (0.01–0.08)

0.14

0.03

 Male

10 (4999)

0.04 (−0.04–0.12)

0.13

0.36

 Female

13 (3662)

0.09 (0.01–0.16)

0.43

0.02

 Caucasian

18 (6226)

0.00 (−0.05–0.05)

0.71

0.95

 Asian

31 (11,417)

0.10 (0.05–0.15)

0.10

< 0.01

 African

3 (277)

1.16 (−0.94–3.25)

< 0.01

0.28

 Other ethnicity

13 (11,504)

−0.02 (− 0.10–0.06)

0.23

0.67

 CAD

9 (2807)

0.00 (−0.08–0.07)

0.77

0.92

 T2DM

6 (799)

0.01 (−0.25–0.26)

0.02

0.96

 Hypertension

5 (10,843)

0.06 (−0.05–0.18)

0.12

0.30

 Healthy or control

25 (8989)

0.07 (0.01–0.13)

0.02

0.02

HDL-C

 All

76 (76,811)

−0.02 (− 0.05–0.02)

< 0.01

0.30

 Studies in HWE

57 (61,438)

−0.02 (− 0.03--0.00)

0.72

0.04

 Male

10 (3467)

−0.04 (− 0.11–0.03)

0.79

0.29

 Female

14 (28,630)

−0.05 (− 0.12–0.02)

0.10

0.19

 Caucasian

25 (51,768)

−0.03 (− 0.07–0.01)

0.02

0.16

 Asian

25 (9553)

0.00 (−0.06–0.06)

< 0.01

0.92

 African

2 (186)

0.15 (− 0.14–0.43)

0.99

0.32

 Other ethnicity

3 (282)

−0.10 (− 0.18--0.02)

0.26

0.01

 CAD

8 (2570)

0.05 (− 0.04–0.13)

0.65

0.27

 T2DM

6 (799)

0.01 (−0.14–0.16)

0.88

0.89

 Hypertension

4 (1522)

−0.03 (− 0.15–0.08)

0.85

0.56

 Healthy or control

32 (56,554)

0.00 (− 0.05–0.04)

< 0.01

0.97

  1. MTHFR 5,10-methylenetetrahydrofolate reductase gene, SMD standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium, TG triglyceride, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, CAD coronary artery disease, T2DM type 2 diabetes mellitus
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Lipids in Health and Disease

ISSN: 1476-511X