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Table 2 Meta-analysis between the MTHFR rs1801133 polymorphism and plasma lipid levels

From: Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis

Group or subgroup Comparison (Subjects) SMD (95% CI) P Heterogeneity P SMD
TG
 All 62 (39,760) 0.03 (−0.01–0.06) < 0.01 0.11
 Studies in HWE 46 (34,889) 0.01 (− 0.01–0.03) 0.11 0.44
 Male 4 (2518) 0.00 (− 0.08–0.08) 0.71 0.96
 Female 8 (1589) 0.13 (− 0.07–0.33) 0.01 0.21
 Caucasian 25 (29,136) 0.00 (−0.04–0.04) 0.11 0.93
 Asian 24 (8639) 0.05 (−0.02–0.13) < 0.01 0.16
 African 2 (191) 0.20 (−0.09–0.48) 0.65 0.18
 Other ethnicity 11 (1794) 0.07 (−0.03–0.17) 0.79 0.15
 CAD 10 (2907) 0.01 (−0.06–0.09) 0.54 0.74
 T2DM 6 (812) 0.07 (−0.14–0.28) 0.09 0.51
 Hypertension 4 (1522) 0.03 (−0.09–0.15) 0.70 0.63
 Healthy or control 17 (26,612) 0.01 (−0.02–0.04) 0.33 0.50
TC
 All 79 (72,848) 0.04 (0.01–0.07) < 0.01 0.02
 Studies in HWE 57 (51,283) 0.01 (−0.00–0.03) 0.13 0.12
 Male 11 (5067) 0.03 (−0.05–0.11) 0.18 0.52
 Female 15 (28,790) 0.11 (0.02–0.19) 0.01 0.02
 Caucasian 26 (41,744) 0.00 (−0.05–0.04) 0.02 0.95
 Asian 36 (13,385) 0.10 (0.04–0.15) 0.01 < 0.01
 African 3 (277) −0.32 (−1.24–0.60) < 0.01 0.49
 Other ethnicity 14 (17,442) −0.01 (− 0.04–0.02) 0.48 0.55
 CAD 9 (2676) 0.02 (−0.06–0.10) 0.45 0.66
 T2DM 5 (705) 0.03 (−0.20–0.27) 0.09 0.77
 Hypertension 6 (11,288) −0.02 (− 0.06–0.02) 0.47 0.34
 Healthy or control 31 (49,859) 0.07 (0.02–0.12) < 0.01 < 0.01
LDL-C
 All 65 (29,424) 0.07 (0.01–0.12) < 0.01 0.01
 Studies in HWE 45 (13,946) 0.04 (0.01–0.08) 0.14 0.03
 Male 10 (4999) 0.04 (−0.04–0.12) 0.13 0.36
 Female 13 (3662) 0.09 (0.01–0.16) 0.43 0.02
 Caucasian 18 (6226) 0.00 (−0.05–0.05) 0.71 0.95
 Asian 31 (11,417) 0.10 (0.05–0.15) 0.10 < 0.01
 African 3 (277) 1.16 (−0.94–3.25) < 0.01 0.28
 Other ethnicity 13 (11,504) −0.02 (− 0.10–0.06) 0.23 0.67
 CAD 9 (2807) 0.00 (−0.08–0.07) 0.77 0.92
 T2DM 6 (799) 0.01 (−0.25–0.26) 0.02 0.96
 Hypertension 5 (10,843) 0.06 (−0.05–0.18) 0.12 0.30
 Healthy or control 25 (8989) 0.07 (0.01–0.13) 0.02 0.02
HDL-C
 All 76 (76,811) −0.02 (− 0.05–0.02) < 0.01 0.30
 Studies in HWE 57 (61,438) −0.02 (− 0.03--0.00) 0.72 0.04
 Male 10 (3467) −0.04 (− 0.11–0.03) 0.79 0.29
 Female 14 (28,630) −0.05 (− 0.12–0.02) 0.10 0.19
 Caucasian 25 (51,768) −0.03 (− 0.07–0.01) 0.02 0.16
 Asian 25 (9553) 0.00 (−0.06–0.06) < 0.01 0.92
 African 2 (186) 0.15 (− 0.14–0.43) 0.99 0.32
 Other ethnicity 3 (282) −0.10 (− 0.18--0.02) 0.26 0.01
 CAD 8 (2570) 0.05 (− 0.04–0.13) 0.65 0.27
 T2DM 6 (799) 0.01 (−0.14–0.16) 0.88 0.89
 Hypertension 4 (1522) −0.03 (− 0.15–0.08) 0.85 0.56
 Healthy or control 32 (56,554) 0.00 (− 0.05–0.04) < 0.01 0.97
  1. MTHFR 5,10-methylenetetrahydrofolate reductase gene, SMD standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium, TG triglyceride, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, CAD coronary artery disease, T2DM type 2 diabetes mellitus