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Table 3 Meta-analysis between the MTHFR rs1801133 polymorphism and CAD risk after excluding the studies with heterogeneity

From: Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis

Comparisons Ethnicity OR 95% CI P heterogeneity P OR
Allelic model
(T vs C)
Total 1.04 1.01–1.07 0.12 0.01
Male 1.04 0.94–1.14 0.13 0.48
Female 1.04 0.93–1.16 0.80 0.53
Caucasian 1.03 1.00–1.06 0.32 0.07
Asian 1.11 1.04–1.18 0.32 < 0.01
African 0.94 0.78–1.13 0.11 0.50
Other ethnicity 0.97 0.83–1.14 0.13 0.74
Additive model
(TT vs CC)
Total 1.12 1.05–1.19 0.09 < 0.01
Male 1.07 0.91–1.27 0.23 0.42
Female 1.02 0.79–1.31 0.82 0.87
Caucasian 1.08 1.01–1.16 0.57 0.03
Asian 1.28 1.12–1.46 0.05 < 0.01
African 0.79 0.50–1.26 0.26 0.32
Other ethnicity 1.23 0.91–1.66 0.10 0.17
Dominant model
(TT + CT vs CC)
Total 1.04 1.00–1.07 0.14 0.05
Male 1.04 0.94–1.15 0.16 0.44
Female 1.07 0.91–1.25 0.51 0.42
Caucasian 1.01 0.97–1.05 0.61 0.56
Asian 1.15 1.05–1.25 0.14 < 0.01
African 1.01 0.81–1.26 0.07 0.94
Other ethnicity 1.04 0.86–1.26 0.10 0.67
Recessive model
(TT vs CT + CC)
Total 1.12 1.06–1.18 0.13 < 0.01
Male 1.15 0.99–1.33 0.05 0.06
Female 0.95 0.77–1.17 0.76 0.62
Caucasian 1.07 1.01–1.14 0.68 0.03
Asian 1.28 1.14–1.43 0.06 < 0.01
African 0.78 0.52–1.18 0.29 0.24
Other ethnicity 1.22 0.93–1.60 0.18 0.16
  1. MTHFR 5,10-methylenetetrahydrofolate reductase gene, CAD coronary artery disease, OR odds ratio, 95% CI 95% confidence interval