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Table 4 Meta-analysis between the MTHFR rs1801133 polymorphism and plasma lipid levels after excluding the comparisons with heterogeneity

From: Associations of the MTHFR rs1801133 polymorphism with coronary artery disease and lipid levels: a systematic review and updated meta-analysis

Group or subgroup Comparison
(Subjects)
SMD (95% CI) P Heterogeneity P SMD
TG
 All 59 (39,196) 0.01 (−0.01–0.03) 0.32 0.22
 Male 4 (2518) 0.00 (− 0.08–0.08) 0.71 0.96
 Female 7 (1429) 0.02 (− 0.09–0.13) 0.06 0.74
 Caucasian 24 (28,976) 0.01 (− 0.02–0.03) 0.31 0.54
 Asian 22 (8235) 0.02 (−0.03–0.06) 0.17 0.50
 African 2 (191) 0.20 (−0.09–0.48) 0.65 0.18
 Other ethnic 11 (1794) 0.07 (−0.03–0.17) 0.79 0.15
 CAD 10 (2907) 0.01 (−0.06–0.09) 0.54 0.74
 T2DM 6 (812) 0.07 (−0.08–0.22) 0.09 0.35
 Hypertension 4 (1522) 0.03 (−0.09–0.15) 0.70 0.63
 Healthy or control 17 (26,612) 0.01 (−0.01–0.04) 0.33 0.28
TC
 All 70 (70,024) 0.01 (−0.00–0.03) 0.38 0.15
 Male 11 (5067) 0.02 (−0.04–0.08) 0.18 0.44
 Female 11 (28, 074) 0.02 (−0.00–0.04) 0.54 0.09
 Caucasian 22 (41,176) 0.01 (−0.01–0.03) 0.81 0.42
 Asian 32 (11,220) 0.06 (0.02–0.10) 0.34 < 0.01
 African 2 (186) 0.15 (−0.14–0.44) 0.15 0.31
 Other ethnic 14 (17,442) −0.01 (− 0.04–0.02) 0.48 0.55
 CAD 10 (2907) 0.02 (−0.06–0.10) 0.45 0.66
 T2DM 5 (705) 0.07 (−0.09–0.23) 0.09 0.38
 Hypertension 6 (11,288) −0.02 (− 0.06–0.02) 0.47 0.34
 Healthy or control 26 (47,611) 0.02 (−0.00–0.04) 0.36 0.08
LDL-C
 All 62 (18,739) 0.04 (0.01–0.07) 0.10 0.01
 Male 10 (4999) 0.04 (−0.02–0.10) 0.13 0.24
 Female 13 (3662) 0.09 (0.01–0.16) 0.43 0.02
 Caucasian 18 (6226) 0.00 (−0.05–0.05) 0.71 0.95
 Asian 30 (10,439) 0.08 (0.04–0.12) 0.16 < 0.01
 African 2 (186) −0.17 (−0.46–0.12) 0.14 0.25
 Other ethnic 12 (1888) 0.00 (−0.10–0.09) 0.19 0.98
 CAD 9 (2807) 0.00 (−0.08–0.07) 0.77 0.92
 T2DM 6 (799) 0.06 (−0.09–0.21) 0.02 0.43
 Hypertension 4 (1227) 0.14 (0.01–0.27) 0.87 0.03
 Healthy or control 24 (8011) 0.06 (0.01–0.11) 0.06 0.01
HDL-C
 All 70 (65,091) −0.02 (−0.03--0.00) 0.48 0.05
 Male 10 (3467) −0.04 (− 0.11–0.03) 0.79 0.29
 Female 14 (28,630) −0.01 (− 0.03–0.02) 0.10 0.61
 Caucasian 23 (51,561) −0.02 (− 0.03–0.00) 0.49 0.08
 Asian 33 (11,456) −0.02 (− 0.06–0.02) 0.22 0.42
 African 2 (186) 0.15 (−0.14–0.43) 0.99 0.32
 Other ethnic 12 (1888) −0.04 (− 0.13–0.05) 0.70 0.41
 CAD 9 (2766) 0.03 (−0.06–0.11) 0.99 0.54
 T2DM 6 (799) 0.01 (−0.14–0.16) 0.88 0.89
 Hypertension 4 (1522) −0.03 (− 0.15–0.08) 0.85 0.56
 Healthy or control 30 (54,825) −0.02 (− 0.03–0.00) 0.05 0.06
  1. MTHFR 5,10-methylenetetrahydrofolate reductase gene, SMD standardized mean difference, 95% CI 95% confidence interval, TG triglyceride, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, CAD coronary artery disease, T2DM type 2 diabetes mellitus