Fig. 1

Circulating miRNAs levels in isolated low HDL-C phenotype. Circulating miR-221-3p levels (a) are increased in isolated low HDL-C phenotype, whereas circulating miR-222-3p levels (b) are decreased in isolated low HDL-C phenotype. Isolated low HDL: Isolated low HDL-C phenotype; Normal: Normal lipid phenotype. miR-221-3p levels (c) are significantly increased in female subjects with both isolated low HDL-C phenotype and normal lipid phenotype in comparison with those of male subgroups. d Circulating miR-222-3p levels are significantly increased in either male or female isolated low HDL-C phenotype compared with the corresponding normal lipid phenotypes, respectively. The p value is adjusted using the Benjamini-Hochberg (BH) method in multiple comparisons