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Table 2 The performance of circulating miR-222-3p and miR-221/.222 Ct ratio for predicting isolated low HDL-C phenotype

From: The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype

Models

AUC (95%CI)

p value

Cut-off value

Specificity

Sensitivity

miR-222-3p

0.648 (0.566, 0.730)

< 0.001

0.559

0.837

0.432

The miR-221-3p/miR-222-3p ratio

0.678 (0.598, 0.758)

< 0.001

0.562

0.767

0.568

Clinical model

0.771 (0.702, 0.840)

< 0.001

0.462

0.698

0.761

Clinical model + miR-222-3pa

0.816 (0.754, 0.879) b

< 0.001

0.413

0.663

0.879

Clinical model + miR221-3p/miR-222-3p ratioa

0.813 (0.751, 0.876) b

< 0.001

0.423

0.686

0.818

  1. AUC area under the curve. Best threshold of Cut-off value were estimated using youden method. a The AUC, sensitivities and specificities of the combination model of miR-222-3p and clinical model was compared with that of clinical model. bp < 0.05
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Lipids in Health and Disease

ISSN: 1476-511X