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Table 3 The AUCs’ performance for distinguishing subjects with isolated low HDL-C phenotype in gender-based analysis

From: The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype

Models

AUC (95%CI)

p value

Cut-off value

Specificity

Sensitivity

Male subjects

 miR-222-3p

0.671 (0.566, 0.730)

0.002

0.474

0.667

0.622

 miR-221-3p/miR-222-3p ratio

0.731 (0.626, 0.836)

< 0.001

0.564

0.800

0.622

 Clinical model

0.759 (0.659, 0.859)

< 0.001

0.630

0.867

0.556

 Clinical model + miR-222-3pa

0.813 (0.721, 0.904)

< 0.001

0.522

0.800

0.778

 Clinical model + miR-221-3p/miR-222-3p ratioa

0.851 (0.770, 0.933)c

< 0.001

0.430

0.756

0.889

Female subjects

 miR-222-3p

0.623 (0.501, 0.745)

0.026

0.600

0.878

0.417

 miR-221-3p/miR-222-3p ratio

0.624 (0.503, 0.745)

0.025

0.566

0.780

0.512

 Clinical model

0.808 (0.714, 0.901)

< 0.001

0.548

0.854

0.674

 Clinical model + miR-222-3pb

0.847 (0.761, 0.934)

< 0.001

0.421

0.780

0.837

 Clinical model + miR-221-3p/miR-222-3p ratiob

0.841 (0.756, 0.926)

< 0.001

0.556

0.853

0.721

  1. AUC area under the curve. Best threshold of Cut-off value were estimated using youden method
  2. a, b The AUC, sensitivities and specificities of the combination model of either miR-222-3p or miR-221-3p/miR-222-3p ratio and clinical indexes were compared with that of the predictive clinical model for male and female subjects, respectively
  3. cp < 0.05