Fig. 5

The effect of FGF21 on apoptosis is dependent on the Fas signaling pathway in apoE−/− mice. a, b Fas and FADD mRNA relative expression was measured and quantified in the aortic root region of hearts from apoE−/− mice treated with or without FGF21. c, d Fas and FADD protein levels in the aortic root region of hearts from apoE−/− mice treated with or without FGF21 were measured and quantified by western blotting. ***p < 0.001, **p < 0.01 vs. C57BL6 mice; ###p < 0.001, #p < 0.05 vs. apoE−/− mice