Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes

Table 3 Serum lipid parameters in each group

SR-BI genotype	Gender	N	TC (mmol/L)	TG (mmol/L)	HDL-C (mmol/L)	LDL-C (mmol/L)
SR-BI^+/+	Male	6	1.84 ± 0.19	0.88 ± 0.17	1.22 ± 0.11	0.15 ± 0.04
	Female	6	1.77 ± 0.17	0.76 ± 0.11	1.05 ± 0.06	0.18 ± 0.03
	Both	12	1.81 ± 0.18	0.82 ± 0.15	1.13 ± 0.12	0.16 ± 0.03
SR-BI^+/−	Male	6	2.40 ± 0.40	1.14 ± 0.37	1.46 ± 0.22	0.19 ± 0.04
	Female	5	2.20 ± 0.22^c	0.78 ± 0.17	1.21 ± 0.08^c	0.20 ± 0.05
	Both	11	2.31 ± 0.33^e	0.98 ± 0.34	1.35 ± 0.21	0.20 ± 0.04
SR-BI^−/−	Male	5	4.26 ± 0.64*^a	0.94 ± 0.16	1.71 ± 0.46*	0.21 ± 0.10
	Female	5	4.11 ± 0.40^bd	0.86 ± 0.16	1.53 ± 0.10^bd	0.18 ± 0.04
	Both	10	4.19 ± 0.51^fg	0.90 ± 0.16	1.62 ± 0.33^fh	0.21 ± 0.08

Note: TC (total cholesterol), TG (Triglycerides), HDL-C (high density lipoprotein cholesterol), LDL-C (low density lipoprotein cholesterol), values are representative of both sexes, n = 5–6 per group, mean ± SD
1) Males:*P < 0.05 vs. SR-BI^+/+ group; ^aP < 0.01 vs. SR-BI^+/− group;
2) Female:^bP < 0.001 vs. SR-BI^+/+ group; ^cP < 0.01 vs. SR-BI^+/+ group; ^dP < 0.001 vs. SR-BI^+/− group;
3) Both:^eP < 0.01 vs. SR-BI^+/+ group; ^fP < 0.001 vs. SR-BI^+/+ group; ^gP < 0.001 vs. SR-BI^+/− group; ^hP < 0.01 vs. SR-BI^+/− group