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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Lipidomic profiling of extracellular vesicles derived from prostate and prostate cancer cell lines

Fig. 1

EVs from tumourigenic cell lines have differences in molecular lipid composition compared to EVs from non-tumourigenic cells. a NTA characterisation of EVs size distribution and concentration. b Detection of common EV-enriched proteins CD29, Alix, CD63 and CD9 by western blot using 1 × 108 EVs per lane. c Heatmap of distinct clusters of enriched lipid species in RWPE1, NB26 and PC-3 EVs generated using the Euclidian distance measure and Ward clustering in MetaboAnalyst. d-f The overall composition of RWPE1, NB26 and PC-3 EVs based on the abundance of lipids in each lipid category. Sphingolipids included Cer, DHCer, GM3, HexCer and SM species, glycerolipids included DG and TG species, glycerophospholipids included LPC, LPE, PC, PE, PI, PG and PS species, others included acylcarnitine and ubiquinone

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