Serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with CAD risk and lipid profiles in southern Chinese Han population

Cai, Gaojun; Yu, Lei; Huang, Zhiying; Li, Li; Fu, Xingli

doi:10.1186/s12944-018-0859-5

Lipids in Health and Disease

Table 3 Association of PCSK9 E670G polymorphism and CAD risk

From: Serum PCSK9 levels, but not PCSK9 polymorphisms, are associated with CAD risk and lipid profiles in southern Chinese Han population

			CAD (n)	Controls (n)	Crude OR (95% CI)	P	Adjusted OR (95% CI)	P ^@
All		AA	567	417	0.819 (0.553–1.212)	0.317	0.838 (0.548–1.280)	0.414
All		AG + GG	59	53	0.819 (0.553–1.212)	0.317	0.838 (0.548–1.280)	0.414
Gender	Male	AA	396	220	0.960 (0.564–1.636)	0.882	0.952 (0.541–1.675)	0.864
	Male	AG + GG	43	23	0.960 (0.564–1.636)	0.882	0.952 (0.541–1.675)	0.864
	Female	AA	171	197	1.636 (0.862–3.104)	0.132	0.706 (0.345–1.445)	0.341
	Female	AG + GG	16	30	1.636 (0.862–3.104)	0.132	0.706 (0.345–1.445)	0.341
Age	≥ 60 (years)	AA	407	268	0.850(0.530–1.365)	0.501	0.790(0.363–1.509)	0.407
	≥ 60 (years)	AG + GG	44	34	0.850(0.530–1.365)	0.501	0.790(0.363–1.509)	0.407
	< 60 (years)	AA	159	149	0.740(0.363–1.509)	0.407	0.896(0.408–1.970)	0.785
	< 60 (years)	AG + GG	15	19	0.740(0.363–1.509)	0.407	0.896(0.408–1.970)	0.785
EH	Yes	AA	415	244	0.717 (0.437–1.174)	0.186	0.688 (0.406–1.165)	0.164
	Yes	AG + GG	39	32	0.717 (0.437–1.174)	0.186	0.688 (0.406–1.165)	0.164
	No	AA	152	173	1.084 (0.566–2.076)	0.808	1.260 (0.586–2.709)	0.554
	No	AG + GG	20	21	1.084 (0.566–2.076)	0.808	1.260 (0.586–2.709)	0.554
DM	Yes	AA	149	57	0.946 (0.583–1.532)	0.820	0.497 (0.193–1.278)	0.147
	Yes	AG + GG	14	10	0.946 (0.583–1.532)	0.820	0.497 (0.193–1.278)	0.147
	No	AA	418	360	0.901 (0.580–1.401)	0.644	0.536 (0.225–1.275)	0.158
	No	AG + GG	45	43	0.901 (0.580–1.401)	0.644	0.536 (0.225–1.275)	0.158
Smoking	Yes	AA	219	105	1.065 (0.469–2.420)	0.880	1.055 (0.443–2.512)	0.903
	Yes	AG + GG	20	9	1.065 (0.469–2.420)	0.880	1.055 (0.443–2.512)	0.903
	No	AA	348	312	0.795 (0.503–1.255)	0.325	0.834 (0.498–1.397)	0.490
	No	AG + GG	39	44	0.795 (0.503–1.255)	0.325	0.834 (0.498–1.397)	0.490

CAD coronary artery disease, OR odds ratio, CI confidence interval
^@Aadjustment with age, gender, smoking, EH, DM and lipid profiles

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