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Table 2 The Significantly different metabolites in heart of mice

From: Profile of cardiac lipid metabolism in STZ-induced diabetic mice

Class

Metabolites

FC(Diabetic/Control)

log2(FC)

Vip Value

p Value

Hydroxyl-fatty-acyl-carnitine

2-Hydroxymyristoylcarnitine(18:0)

3.182

1.66993

1.133

0.0472

3-Hydroxy-cis-tetradecenoylcarnitine(14:1)

10.212

3.35219

1.174

0.0308

3-Hydroxy-tetradecadiencarnitine(14:2)

2.552

1.35163

1.230

0.0163

3-Hydroxyhexadecanoylcarnitine(16:0)

11.681

3.54609

1.230

0.0323

3-Hydroxy-hexadecenoylcarnitine(16:1)

2.500

1.32193

1.188

0.0433

3-Hydroxyhexadecadienoylcarnitine(16:2)

2.721

1.44414

1.146

0.0450

3-Hydroxy-octadecenoylcarnitine(18:1)

3.077

1.62152

1.139

0.0465

12-Hydroxy-octadecanoylcarnitine(18:0)

3.293

1.71940

1.061

0.0467

Fatty-acyl-carnitine

Decenoylcarnitine(10:1)

0.033

−4.93669

1.324

< 0.0001

Dodecanoylcarnitine(12:0)

0.202

−2.30685

1.335

< 0.0001

Tetradecanoylcarnitine(14:0)

0.481

−1.05589

1.076

< 0.0001

Docosa-pentaenoyl carnitine(22:5)

0.455

− 1.13488

1.247

0.0079

L-Palmitoylcarnitine(16:0)

2.421

1.27560

1.062

0.0107

trans-Hexadec-enoyl carnitine(16:1)

2.132

1.09221

1.112

0.0224

Hexadecadienoylcarnitine(16:2)

2.594

1.37518

1.349

0.0630

Stearoylcarnitine(18:0)

2.404

1.26544

1.050

0.0130

Linoelaidyl carnitine(18:2)

2.053

1.03773

1.016

0.0182

Gamma-linolenyl carnitine(18:3)

2.202

1.13881

1.123

0.0189

Arachidyl carnitine(20:0)

0.429

−1.22219

1.095

0.0200

Fatty acid

Eicosenoic acid(20:1)

0.459

−1.12499

1.347

< 0.0001

Eicosapentaenoic acid(20:5)

0.479

−1.06212

1.143

< 0.0001

Docosadienoate(22:2)

0.089

−3.48877

1.343

< 0.0001

Docosahexaenoate(22:6)

0.067

−3.90785

1.322

< 0.0001

Tetracosahexaenoic acid(24:6)

0.215

−2.21475

1.384

< 0.0001

Docosapentaenoic acid(22:5)

2.084

1.05936

1.275

0.0079

Triglyceride (TG)

TG 14:1/18:4/14:1

0.365

−1.45418

1.152

0.0284

TG 18:3/18:4/18:3

0.263

−1.92638

1.189

0.0024

TG 20:4/24:1/20:4

0.350

−1.51450

1.046

0.0033

TG 14:1/20:5/14:1

6.763

2.75766

1.295

< 0.0001

TG 16:1/18:0/16:1

3.448

1.78576

1.065

0.0268

Diacylglycerol (DG)

DG 20:0/24:1/0:0

0.411

−1.28451

1.335

< 0.0001

DG 22:0/0:0/22:6

0.109

−3.20398

1.089

0.0078

DG 24:1/22:0/0:0

0.454

−1.13881

1.049

0.0006

DG 24:1/24:0/0:0

0.354

−1.49621

1.206

0.0005

DG 14:0/20:5/0:0

2.538

1.34369

1.372

< 0.0001

DG 14:1/22:6/0:0

4.715

2.23726

1.393

< 0.0001

DG 18:4/18:4/0:0

4.079

2.02822

1.395

< 0.0001

phospholipid

 Phosphatidylcholine (PC)

PC 14:0/16:1

0.135

−2.89414

1.026

0.0150

PC 14:0/18:2

0.228

−2.13027

1.030

0.0094

PC 14:0/22:5

0.409

−1.28924

1.091

0.0340

PC 14:1/22:6

0.103

−3.27769

1.192

0.0014

PC P-16:0/18:3

0.305

−1.71326

1.050

0.0121

PC P-16:0/20:3

0.392

−1.35276

1.333

0.0003

PC P-18:1/18:3

0.353

−1.50131

1.075

0.0236

PC 18:3/P-16:0

0.411

−1.28155

1.043

0.0199

PC 20:5/P-18:1

0.410

−1.28570

1.056

0.0258

PC 20:5/18:3

0.110

−3.18412

1.712

0.0240

PC 20:5/14:0

0.428

−1.22342

1.243

0.0147

PC 14:1/20:5

2.075

1.05311

1.303

< 0.0001

PC 16:0/22:5

2.316

1.21164

1.163

0.0023

PC 18:2/22:6

6.391

2.67604

1.086

0.0056

PC 22:4/16:0

2.178

1.12300

1.301

< 0.0001

PC 22:4/24:1

2.018

1.01293

1.288

< 0.0001

PC 22:5/16:0

2.358

1.23756

1.207

0.0011

PC 22:6/18:1

2.065

1.04614

1.211

0.0012

PC 22:6/18:2

5.212

2.38184

1.161

0.0019

 Lysophosphatidylcholine (LysoPC)

LysoPC 16:1

0.203

−2.30217

1.254

< 0.0001

LysoPC 20:2

0.072

−3.79286

1.282

< 0.0001

LysoPC 22:1

0.130

−2.94823

1.201

0.0012

LysoPC 22:2

0.122

−3.04002

1.213

0.0010

LysoPC 22:6

0.128

−2.96532

1.208

0.0011

LysoPC 14:1

2.016

1.01150

1.005

0.0243

LysoPC 18:0

2.145

1.10098

1.023

0.0108

LysoPC P-18:1

2.111

1.07793

1.030

0.0101

LysoPC 20:3

2.254

1.17249

1.092

0.0055

 Phosphoethanolamine (PE)

PE 14:0/14:0

0.028

−5.16792

1.276

< 0.0001

PE P-16:0e/0:0

0.167

−2.58448

1.184

0.0016

PE O-16:0/18:1

0.091

−3.46205

1.114

0.0091

PE P-18:0/18:3

0.338

−1.56365

1.171

0.0232

PE 18:4/18:4

0.122

−3.02998

1.213

0.0010

PE 22:0/14:0

0.259

−1.94935

1.440

< 0.0001

PE 22:6/18:0

0.303

−1.72072

1.312

< 0.0001

PE 14:0/18:3

8.300

3.05311

1.423

< 0.0001

PE 16:1/20:1

5.469

2.45128

1.352

< 0.0001

PE P-18:1/20:4

3.854

1.94636

1.287

< 0.0001

PE 22:6/20:0

2.035

1.02503

1.282

< 0.0001

 Lysophosphatidylethanolamine (LysoPE)

LysoPE 14:0

0.465

−1.10434

1.158

0.0022

LysoPE 18:1

0.315

−1.66585

1.268

< 0.0001

LysoPE 20:1

0.150

−2.73314

1.232

0.0007

LysoPE 22:1

0.209

−2.26093

1.258

< 0.0001

LysoPE 22:2

0.190

−2.39890

1.237

0.0006

LysoPE 22:6

0.122

−3.03386

1.213

0.0010

LysoPE 24:6

0.116

−3.11103

1.248

0.0005

LysoPE 22:0

2.026

1.01863

1.021

0.0326

LysoPE 22:4

2.339

1.22589

1.214

0.0008

LysoPE 24:1

3.518

1.81476

1.180

0.0048

 phosphatidic acid (PA)

PA 20:4e/2:0

0.127

−2.97911

1.175

0.0019

 Lysophosphatidic acid (LysoPA)

LysoPA 18:1

0.202

−2.30918

1.203

0.0011

 Phosphatidylglycerol (PG)

PG 12:0/18:4

0.165

−2.59837

1.235

0.0006

PGP 16:0/16:0

0.109

−3.19141

1.185

0.0210

PG 18:1/16:1

0.168

−2.57628

1.297

< 0.0001

PG 18:1/18:1

0.109

−3.20383

1.211

0.0010

PG 18:1/20:4

0.110

−3.18713

1.207

0.0011

PG 18:3/22:5

0.106

−3.24031

1.289

< 0.0001

PG 16:0/18:3

6.018

2.58928

1.353

< 0.0001

PG 18:1/18:3

2.525

1.33628

1.078

0.0058

 Phosphatidylserine (PS)

PS 12:0/18:2

0.163

−2.61965

1.260

< 0.0001

PS 14:1/20:4

0.117

−3.09238

1.189

0.0014

PS 18:0/18:1

0.478

−1.06626

1.334

< 0.0001

PS 18:0/22:5

0.394

−1.34426

1.137

0.0055

PS 18:1/18:1

0.412

−1.27977

1.611

0.0279

PS 20:4/16:1

0.274

−1.86632

1.293

< 0.0001

PS 18:0/18:0

5.065

2.34056

1.257

< 0.0001

PS 20:3/18:0

5.523

2.46545

1.230

0.0007

 Phosphatidylinositol (PI)

PI 18:0/16:0

0.457

−1.12829

1.064

0.0211

PI 22:0/0:0

0.130

−2.94505

1.203

0.0012

PI 16:0/16:0

2.180

1.12433

1.211

0.0010

PI 16:0/16:1

2.423

1.27679

1.176

0.0020

 Sphingomyelin (SM)

SM d18:0/16:0

0.100

−3.32034

1.121

0.0127

SM d18:0/16:1

0.303

−1.72072

1.058

0.0358

SM d18:0/18:1

0.126

−2.98841

1.208

0.0010

SM d18:0/22:0

0.329

−1.60549

1.055

0.0236

SM d18:0/22:3

0.227

−2.14176

1.342

< 0.0001

SM d18:0/26:1

0.099

−3.33914

1.202

0.0012

  1. FC fold change, VIP value variable importance in the projection; p Value, from Student t test and vs. diabetic group; Metabolites, lipids displaying significant changes between control and diabetic heart (P < 0.05 and VIP > 1)
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Lipids in Health and Disease

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