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Table 2 Allele and Genotype distribution of the selected SNPs among the cases and the controls

From: Genetic risk score (GRS) constructed from polymorphisms in the PON1, IL-6, ITGB3, and ALDH2 genes is associated with the risk of coronary artery disease in Pakistani subjects

SNP

Genotype/MAF

Controls (n = 219)

Cases (n = 404)

OR (CI)

p-value

rs662 (PON1)

AA

84

118

1.15 (0.898–1.470)

0.02

AG

84

175

GG

51

111

MAF

0.425

0.491

rs5918 (ITGB3)

CC

129

190

1.179 (0.931–1.477)

0.05

CT

64

171

TT

26

43

MAF

0.256

0.318

rs671 (ALDH2)

GG

101

168

0.993 (0.770–1.28)

0.421

GA

93

190

AA

25

46

MAF

0.326

0.349

rs1800795 (IL-6)

GG

96

194

1.21 (0.943–1.540)

0.153

GC

90

133

CC

33

99

MAF

0.356

0.388

  1. Legend: Selected SNPs allele/genotype frequencies, MAF Minor Allele Frequency, p-value indicates the significance of difference in genotype frequencies between cases and controls from chi-squared test, Odds ratios are for risk alleles. CI Confidence Interval