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Table 3 Comparison of the effect of genotypes of Singlr SNPs and combined GRS

From: Genetic risk score (GRS) constructed from polymorphisms in the PON1, IL-6, ITGB3, and ALDH2 genes is associated with the risk of coronary artery disease in Pakistani subjects

SNP

Genotype

TC (mg/dL)

TG (mg/dL)

LDL-C (mg/dL)

HDL-C (mg/dL)

rs662 (PON1)

AA

175.51 ± 8.47

184.94 ± 7.17

81.38 ± 3.57

70.08 ± 1.77

AG

170.61 ± 3.75

187.89 ± 6.26

77.05 ± 2.32

68.54 ± 1.68

GG

181.25 ± 5.08

196.81 ± 13.8

76.45 ± 1.99

65.54 ± 4.05

P

0.242

0.698

0.496

0.357

rs5918 (ITGB3)

CC

176.18 ± 6.01

184.68 ± 8.08

76.93 ± 2.61

68.76 ± 2.38

CT

178.25 ± 4.12

186.02 ± 6.38

77.17 ± 1.93

69.01 ± 1.64

TT

179.92 ± 5.25

197.79 ± 10.02

78.11 ± 2.91

66.43 ± 2.54

P

0.846

0.549

0.947

0.799

rs671 (ALDH2)

GG

170.28 ± 3.74

185.50 ± 11.97

74.33 ± 3.61

64.11 ± 3.26

GA

175.88 ± 11.76

187.19 ± 6.18

75.88 ± 1.89

76.41 ± 1.86

AA

180.77 ± 4.61

189.41 ± 7.23

79.37 ± 2.26

64.12 ± 1.72

P

0.218

0.954

0.394

0.492

rs1800795 (IL-6)

GG

173.71 ± 7.17

182.02 6.13

72.03 ± 2.52

69.42 ± 3.96

GC

175.51 ± 3.86

190.54 7.70

76.04 ± 1.99

68.01 ± 1.70

CC

177.11 ± 5.14

197.06 10.28

80.47 ± 2.37

65.42 ± 1.76

P

0.866

0.478

0.091

0.714

Genetic Risk Score (GRS) groups

Group I (GRS 0–2)

179.95 ± 5.94

196.13 ± 8.89

79.92 ± 3.94

55.41 ± 2.41

Group II (GRS 3–5)

184.59 ± 2.44

204.08 ± 3.35

85.11 ± 1.54

51.04 ± 1.82

Group III (GRS 6–8)

193.11 ± 5.49

212.60 ± 8.89

93.41 ± 3.20

49.12 ± 1.71

P

0.012

0.001

0.005

1.5 × 10−3

  1. Legend: Values for different lipid parameters are indicated as mean ± S.E Analysis of covariance with age and gender adjusted, p-values indicate the association pattern of the selected SNPs with different anthropometric traits