Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study

Angoorani, Pooneh; Khademian, Majid; Ejtahed, Hanieh-Sadat; Heshmat, Ramin; Motlagh, Mohammad Esmaeil; Vafaeenia, Mahya; Shafiee, Gita; Mahdivi-Gorabi, Armita; Qorbani, Mostafa; Kelishadi, Roya

doi:10.1186/s12944-018-0895-1

Lipids in Health and Disease

Table 4 Receiver operator curve for Non–High-Density lipoprotein fractions for identifying children with MetS

From: Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study

Variable	Age-sex group	Cut-off points (95% CI)	Sensitivity (95% CI)	Specificity (95% CI)	AUC
Non-HDL-C (mg/dl)	7–10 y
	Boy	163 (96.29, 227.70)	0.69 (0.585, 0.807)	0.73 (0.48, 0.97)	0.71
	Girl	104.5 (88.21, 119.78)	0.71 (0.47, 0.95)	0.50 (0.28, 0.70)	0.60
	Total	104.5 (73.99, 134.00)	0.60 (0.28, 0.91)	0.50 (0.14, 0.85)	0.55
	11–14 y
	Boy	119.5 (107.00,130.99)	0.54 (0.34,0.74)	0.73 (0.59,0.85)	0.64
	Girl	116.5 (77.57,154.42)	0.49 (0.10, 0.86)	0.65 (0.21, 1.07)	0.57
	Total	116.5 (111.38, 120.61)	0.53 (0.37, 0.68)	0.67 (0.57, 0.76)	0.60
	15–18 y
	Boy	101.5 (81.67,120.32)	0.91 (0.66,1.16)	0.51 (0.27,0.73)	0.71
	Girl	115.5 (75.49, 154.50)	0.54 (0.07, 1.00)	0.64 (0.14, 1.14)	0.59
	Total	104.5 (83.66, 124.33)	0.79 (0.52, 1.06)	0.52 (0.25, 0.78)	0.65
	7-18y
	Boy	119.5 (103.37, 134.62)	0.49 (0.26, 0.71)	0.73 (0.50, 0.95)	0.61
	Girl	115.5 (88.58, 141.41)	0.49 (0.18, 0.78)	0.64 (0.25, 1.01)	0.56
	Total	120.5 (105.33, 134.66)	0.44 (0.22, 0.65)	0.73 (0.52, 0.93)	0.58
Diff-C (mg/dl)	7–10 y
	Boy	19.9 (17.47, 22.12)	0.78 (0.60, 0.95)	0.78 (0.72, 0.83)	0.78
	Girl	20.7 (15.94, 25.25)	0.89 (0.75, 1.00)	0.78 (0.66, 0.89)	0.84
	Total	19.9 (18.88,20.71)	0.84 (0.73,0.93)	0.77 (0.72,0.81)	0.80
	11–14 y
	Boy	19.9 (18.26, 21.33)	0.83 (0.71, 0.93)	0.77 (0.72, 0.81)	0.80
	Girl	19.9 (18.18, 21.41)	0.82 (0.69, 0.94)	0.73 (0.64, 0.82)	0.78
	Total	19.9 (18.41, 21.18)	0.82 (0.74,0.90)	0.75 (0.71,0.78)	0.79
	15–18 y
	Boy	19.9 (18.05, 21.54)	0.91 (0.83, 0.99)	0.74 (0.67, 0.80)	0.83
	Girl	20.5 (15.45, 25.34)	0.92 (0.75, 1.08)	0.76 (0.68, 0.84)	0.84
	Total	19.9 (19.16,20.43)	0.92 (0.84,0.99)	0.74 (0.70,0.77)	0.83
	7–18 y
	Boy	19.9 (19.26,20.33)	0.84 (0.76,0.91)	0.76 (0.73,0.79)	0.80
	Girl	19.9 (19.37,20.22)	0.86 (0.78,0.93)	0.74 (0.70,0.78)	0.80
	Total	19.9 (19.76, 19.83)	0.85 (0.79,0.90)	0.75 (0.74,0.76)	0.80
Atherogenic index	7–10 y
	Boy	2.53 (1.83,3.23)	0.70 (0.52,0.88)	0.83 (0.70,0.95)	0.77
	Girl	2.57 (2.03,3.10)	0.93 (0.83,1.02)	0.81 (0.69,0.92)	0.87
	Total	2.53 (2.10,2.96)	0.82 (0.72,0.90)	0.81 (0.71,0.91)	0.82
	11–14 y
	Boy	2.58 (2.37,2.78)	0.80 (0.70,0.90)	0.82 (0.78,0.86)	0.81
	Girl	2.54 (1.96,3.11)	0.79 (0.65,0.93)	0.77 (0.61,0.93)	0.78
	Total	2.54 (2.25,2.83)	0.80 (0.70,0.89)	0.80 (0.72,0.87)	0.80
	15–18 y
	Boy	2.48 (2.04,2.91)	0.89 (0.75,1.01)	0.75 (0.65,0.83)	0.82
	Girl	2.73 (2.24,3.22)	0.92 (0.79,1.05)	0.82 (0.75,0.88)	0.87
	Total	2.48 (2.17,2.78)	0.90 (0.79,.99)	0.76 (0.69,0.82)	0.83
	7–18 y
	Boy	2.53 (2.35,2.71)	0.80 (0.71,0.88)	0.80 (0.76,0.83)	0.80
	Girl	2.54 (2.19,2.89)	0.86 (0.77,0.94)	0.79 (0.71,0.86)	0.83
	Total	2.53 (2.41,2.65)	0.82 (0.76,0.88)	0.79 (0.76,0.82)	0.81

CI confidence interval, AUC area under curve, shown as percentage
Non–HDL-C concentration was calculated by subtracting HDL-C value from total cholesterol concentration. Diff-C was defined as the difference between total amount of non-HDL cholesterol and LDL-C (Diff-C = [non-HDL-C]-[LDL-C]). Atherogenic index as the ratio between TG and HDL-C concentrations

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