Table 2 Factors associated with hepatocellular carcinoma in the absence of cirrhosis
Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
OR | 95%CI | P values | OR | 95%CI | P values | |
Age > 50 yrs | 0.46 | 0.34–0.62 | < 0.0001 | 0.42 | 0.25–0.70 | < 0.0001 |
Gender (male) | 1.36 | 0.94–1.98 | 0.11 | |||
Family history of HCC | 2.29 | 1.27–4.14 | 0.006 | 2.91 | 1.07–7.92 | 0.037 |
Diabetes | 0.59 | 0.39–0.89 | 0.012 | |||
Hyperlipidemia | 2.02 | 1.29–3.16 | 0.002 | |||
Etiology | ||||||
HBV | 0.79 | 0.54–1.13 | 0.19 | |||
HCV | 1.43 | 0.92–2.22 | 0.12 | |||
Alcohol abuse | 0.44 | 0.23–0.85 | 0.014 | |||
NAFLD | 6.77 | 2.0–23.32 | 0.002 | |||
HBV-DNA ≥ 500 IU/ml | 0.79 | 0.55–1.11 | 0.18 | |||
Antiviral therapy | 1.04 | 0.69–1.57 | 0.86 | |||
PVTT at baseline | 0.29 | 0.17–0.51 | < 0.0001 | |||
Leukocyte counts ≥4*109/L | 2.31 | 1.79–2.98 | < 0.0001 | |||
PLT ≥100*109/L | 6.23 | 4.31–9.02 | < 0.0001 | 6.67 | 3.32–13.40 | < 0.0001 |
AST ≥ 40 (U/L) | 0.52 | 0.39–0.70 | < 0.0001 | |||
γ-GGT ≥ 60 (U/L) | 0.57 | 0.42–0.77 | < 0.0001 | 0.46 | 0.27–0.78 | 0.004 |
TG ≥ 1.71 mmol/L | 2.46 | 1.50–4.02 | < 0.0001 | 2.66 | 1.18–6.01 | 0.019 |
PTA < 70% | 0.18 | 0.11–0.29 | < 0.0001 | |||
AFP ≥ 400 ng/ml | 1.05 | 0.76–1.47 | 0.75 | |||
Child staging | < 0.0001 | |||||
A | 17.1 | 5.43–53.88 | < 0.0001 | 5.67 | 1.34–24.02 | 0.019 |
B | 2.48 | 0.73–8.40 | 0.15 | |||
C (Reference) | ||||||
BCLC staging | < 0.0001 | |||||
0-A | 13.8 | 4.35–43.77 | < 0.0001 | |||
B | 10.81 | 3.38–34.54 | < 0.0001 | |||
C | 4.52 | 1.32–15.47 | 0.016 | |||
D (Reference) | ||||||