|
Variables
|
Univariate analysis
|
Multivariate analysis
|
|---|
|
HR
|
95%CI
|
P values
|
HR
|
95%CI
|
P values
|
|---|
|
Age > 50 yrs
|
1.01
|
0.99–1.03
|
0.283
| | | |
|
Gender (male)
|
0.85
|
0.51–1.40
|
0.517
| | | |
|
Family history of HCC
|
1.16
|
0.51–2.67
|
0.72
| | | |
|
Alcohol abuse
|
1.76
|
1.18–2.63
|
0.006
| | | |
|
Diabetes
|
1.41
|
0.83–2.38
|
0.202
| | | |
|
Hypertension
|
0.85
|
0.53–1.36
|
0.507
| | | |
|
Hyperlipidemia
|
0.98
|
0.54–1.80
|
0.949
| | | |
|
Etiology
|
|
HBV
|
0.62
|
0.39–0.97
|
0.037
| | | |
|
HCV
|
1.8
|
1.08–3.02
|
0.025
| | | |
|
Alcohol abuse
|
1.54
|
0.71–3.32
|
0.272
| | | |
|
NAFLD
|
2.07
|
0.65–6.54
|
0.216
| | | |
|
HBV-DNA ≥ 500 IU/ml
|
1.36
|
0.88–2.10
|
0.164
| | | |
|
Antiviral therapy
|
0.52
|
0.32–0.86
|
0.011
|
0.53
|
0.32–0.89
|
0.015
|
|
PVTT at baseline
|
6.17
|
3.32–11.46
|
< 0.0001
|
3.4
|
1.73–6.67
|
< 0.0001
|
|
Leukocyte counts
|
1.05
|
0.96–1.14
|
0.332
| | | |
|
NLR
|
0.99
|
0.95–1.03
|
0.675
| | | |
|
Platelets (109/L)
|
1.002
|
0.999–1.005
|
0.193
| | | |
|
AST (U/L)
|
1.002
|
0.998–1.006
|
0.403
| | | |
|
Totall Bilirubin (umol/L)
|
1.005
|
1.002–1.008
|
0.001
| | | |
|
Albumin (g/L)
|
0.939
|
0.902–0.978
|
0.002
| | | |
|
γ-GGT (U/L)
|
1.006
|
1.004–1.008
|
< 0.0001
|
1.006
|
1.004–1.009
|
< 0.0001
|
|
Triglyceride (mmol/L)
|
0.7
|
0.44–1.11
|
0.128
|
0.51
|
0.29–0.89
|
0.017
|
|
PTA (%)
|
0.986
|
0.973–0.999
|
0.032
| | | |
|
AFP ≥ 400 ng/ml
|
2.235
|
1.469–3.40
|
< 0.0001
| | | |
|
Tumor size > 5 cm
|
3.99
|
2.65–6.02
|
< 0.0001
|
2.79
|
1.72–4.50
|
< 0.0001
|
|
Tumor numbers ≥2
|
2.3
|
1.53–3.46
|
< 0.0001
| | | |
|
CRP (mg/L)
|
1.008
|
1.003–1.013
|
0.002
| | | |
- Abbreviations: CRP C-reactive protein
