Variables | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
HR | 95%CI | P values | HR | 95%CI | P values | |
Age > 50 yrs | 1.01 | 0.99–1.03 | 0.283 | |||
Gender (male) | 0.85 | 0.51–1.40 | 0.517 | |||
Family history of HCC | 1.16 | 0.51–2.67 | 0.72 | |||
Alcohol abuse | 1.76 | 1.18–2.63 | 0.006 | |||
Diabetes | 1.41 | 0.83–2.38 | 0.202 | |||
Hypertension | 0.85 | 0.53–1.36 | 0.507 | |||
Hyperlipidemia | 0.98 | 0.54–1.80 | 0.949 | |||
Etiology | ||||||
HBV | 0.62 | 0.39–0.97 | 0.037 | |||
HCV | 1.8 | 1.08–3.02 | 0.025 | |||
Alcohol abuse | 1.54 | 0.71–3.32 | 0.272 | |||
NAFLD | 2.07 | 0.65–6.54 | 0.216 | |||
HBV-DNA ≥ 500 IU/ml | 1.36 | 0.88–2.10 | 0.164 | |||
Antiviral therapy | 0.52 | 0.32–0.86 | 0.011 | 0.53 | 0.32–0.89 | 0.015 |
PVTT at baseline | 6.17 | 3.32–11.46 | < 0.0001 | 3.4 | 1.73–6.67 | < 0.0001 |
Leukocyte counts | 1.05 | 0.96–1.14 | 0.332 | |||
NLR | 0.99 | 0.95–1.03 | 0.675 | |||
Platelets (109/L) | 1.002 | 0.999–1.005 | 0.193 | |||
AST (U/L) | 1.002 | 0.998–1.006 | 0.403 | |||
Totall Bilirubin (umol/L) | 1.005 | 1.002–1.008 | 0.001 | |||
Albumin (g/L) | 0.939 | 0.902–0.978 | 0.002 | |||
γ-GGT (U/L) | 1.006 | 1.004–1.008 | < 0.0001 | 1.006 | 1.004–1.009 | < 0.0001 |
Triglyceride (mmol/L) | 0.7 | 0.44–1.11 | 0.128 | 0.51 | 0.29–0.89 | 0.017 |
PTA (%) | 0.986 | 0.973–0.999 | 0.032 | |||
AFP ≥ 400 ng/ml | 2.235 | 1.469–3.40 | < 0.0001 | |||
Tumor size > 5 cm | 3.99 | 2.65–6.02 | < 0.0001 | 2.79 | 1.72–4.50 | < 0.0001 |
Tumor numbers ≥2 | 2.3 | 1.53–3.46 | < 0.0001 | |||
CRP (mg/L) | 1.008 | 1.003–1.013 | 0.002 |