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Table 1 Clinical characteristics of the unrelated index cases

From: Genetic basis of index patients with familial hypercholesterolemia in Chinese population: mutation spectrum and genotype-phenotype correlation

Characteristics

FH patients (n = 285)

Baseline Data

 Male, n (%)

173 (60.7%)

 Age, year

49 ± 12

 BMI, kg/(m2)

25.32 ± 3.74

 SBP, mm/Hg

125 ± 17.0

 DBP, mm/Hg

78 ± 11.5

 Glucose, mmol/L

5.54 ± 1.47

 Xanthoma, n(%)

28 (9.8%)

 CAD, n (%)

233 (81.8%)

 Family history of CAD, n (%)

124 (43.5%)

Region distribution

 northeast China

65 (22.8%)

 north China

160 (56.1%)

 northwest China

12 (4.2%)

 eastern China

38 (13.3%)

 southern China

8 (2.8%)

 southwest China

2 (0.7%)

Lipids

 TC, mmol/L

7.03 ± 2.53

 HDL-C, mmol/L

1.09 ± 0.32

 LDL-C, mmol/L

5.22 ± 2.12

 Untreated LDL-C, mmol/L

7.86 ± 2.25

 TG, mmol/L

1.67 (1.20–2.14)

 ApoA, g/L

1.31 ± 0.33

 ApoB, g/L

1.47 ± 0.49

 Statin, n (%)

231 (81.1%)

 Ezetimibe, n (%)

17 (6.0%)

  1. Data are expressed as mean ± SD, median (25th–75th percentile) or n (%)
  2. FH familial hypercholesterolemia, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, CAD coronary artery disease, TC total cholesterol, HDL-C HDL cholesterol, LDL-C LDL cholesterol, TG triglyceride, apo A apolipoprotein A, apo B apolipoprotein B