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Table 1 Clinical characteristics of the unrelated index cases

From: Genetic basis of index patients with familial hypercholesterolemia in Chinese population: mutation spectrum and genotype-phenotype correlation

Characteristics FH patients (n = 285)
Baseline Data
 Male, n (%) 173 (60.7%)
 Age, year 49 ± 12
 BMI, kg/(m2) 25.32 ± 3.74
 SBP, mm/Hg 125 ± 17.0
 DBP, mm/Hg 78 ± 11.5
 Glucose, mmol/L 5.54 ± 1.47
 Xanthoma, n(%) 28 (9.8%)
 CAD, n (%) 233 (81.8%)
 Family history of CAD, n (%) 124 (43.5%)
Region distribution
 northeast China 65 (22.8%)
 north China 160 (56.1%)
 northwest China 12 (4.2%)
 eastern China 38 (13.3%)
 southern China 8 (2.8%)
 southwest China 2 (0.7%)
Lipids
 TC, mmol/L 7.03 ± 2.53
 HDL-C, mmol/L 1.09 ± 0.32
 LDL-C, mmol/L 5.22 ± 2.12
 Untreated LDL-C, mmol/L 7.86 ± 2.25
 TG, mmol/L 1.67 (1.20–2.14)
 ApoA, g/L 1.31 ± 0.33
 ApoB, g/L 1.47 ± 0.49
 Statin, n (%) 231 (81.1%)
 Ezetimibe, n (%) 17 (6.0%)
  1. Data are expressed as mean ± SD, median (25th–75th percentile) or n (%)
  2. FH familial hypercholesterolemia, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, CAD coronary artery disease, TC total cholesterol, HDL-C HDL cholesterol, LDL-C LDL cholesterol, TG triglyceride, apo A apolipoprotein A, apo B apolipoprotein B