TY - JOUR AU - Arab, J. P. AU - Candia, R. AU - Zapata, R. PY - 2014 DA - 2014// TI - Management of nonalcoholic fatty liver disease: an evidence-based clinical practice review JO - World J Gastroenterol VL - 20 UR - https://doi.org/10.3748/wjg.v20.i34.12182 DO - 10.3748/wjg.v20.i34.12182 ID - Arab2014 ER - TY - JOUR AU - Bellentani, S. AU - Scaglioni, F. AU - Marino, M. AU - Bedogni, G. PY - 2010 DA - 2010// TI - Epidemiology of non-alcoholic fatty liver disease JO - Dig Dis VL - 28 UR - https://doi.org/10.1159/000282080 DO - 10.1159/000282080 ID - Bellentani2010 ER - TY - JOUR AU - Fazel, Y. AU - Koenig, A. B. AU - Sayiner, M. AU - Goodman, Z. D. AU - Younossi, Z. M. PY - 2016 DA - 2016// TI - Epidemiology and natural history of non-alcoholic fatty liver disease JO - Metabolism VL - 65 UR - https://doi.org/10.1016/j.metabol.2016.01.012 DO - 10.1016/j.metabol.2016.01.012 ID - Fazel2016 ER - TY - JOUR AU - Milic, S. AU - Stimac, D. PY - 2012 DA - 2012// TI - Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment JO - Dig Dis VL - 30 UR - https://doi.org/10.1159/000336669 DO - 10.1159/000336669 ID - Milic2012 ER - TY - JOUR AU - Loomba, R. AU - Sanyal, A. J. PY - 2013 DA - 2013// TI - The global NAFLD epidemic JO - Nat Rev Gastro Hepat VL - 10 UR - https://doi.org/10.1038/nrgastro.2013.171 DO - 10.1038/nrgastro.2013.171 ID - Loomba2013 ER - TY - JOUR AU - Reccia, I. AU - Kumar, J. AU - Akladios, C. PY - 2017 DA - 2017// TI - Non-alcoholic fatty liver disease: a sign of systemic disease JO - Metabolism VL - 72 UR - https://doi.org/10.1016/j.metabol.2017.04.011 DO - 10.1016/j.metabol.2017.04.011 ID - Reccia2017 ER - TY - JOUR AU - Kanuri, G. AU - Bergheim, I. PY - 2013 DA - 2013// TI - In vitro and in vivo models of non-alcoholic fatty liver disease (NAFLD) JO - Int J Mol Sci VL - 14 UR - https://doi.org/10.3390/ijms140611963 DO - 10.3390/ijms140611963 ID - Kanuri2013 ER - TY - JOUR AU - Patsouris, D. AU - Mandard, S. AU - Voshol, P. J. PY - 2004 DA - 2004// TI - PPARα governs glycerol metabolism JO - J Clin Invest VL - 114 UR - https://doi.org/10.1172/JCI200420468 DO - 10.1172/JCI200420468 ID - Patsouris2004 ER - TY - JOUR AU - Rakhshandehroo, M. AU - Hooiveld, G. AU - Müller, M. AU - Kersten, S. PY - 2009 DA - 2009// TI - Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human JO - PLoS One VL - 4 UR - https://doi.org/10.1371/journal.pone.0006796 DO - 10.1371/journal.pone.0006796 ID - Rakhshandehroo2009 ER - TY - JOUR AU - Pyper, S. R. AU - Viswakarma, N. AU - Yu, S. AU - Reddy, J. K. PY - 2010 DA - 2010// TI - PPARα: energy combustion, hypolipidemia, inflammation and cancer JO - Nucl Recept Signal VL - 8 UR - https://doi.org/10.1621/nrs.08002 DO - 10.1621/nrs.08002 ID - Pyper2010 ER - TY - JOUR AU - Cariou, B. AU - Hanf, R. AU - Lambert-Porcheron, S. PY - 2013 DA - 2013// TI - Dual peroxisome proliferator-activated receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects JO - Diabetes Care VL - 36 UR - https://doi.org/10.2337/dc12-2012 DO - 10.2337/dc12-2012 ID - Cariou2013 ER - TY - JOUR AU - Fruchart, J. C. PY - 2013 DA - 2013// TI - Selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα): the next generation of peroxisome proliferator-activated receptor α-agonists JO - Cardiovasc Diabetol VL - 12 UR - https://doi.org/10.1186/1475-2840-12-82 DO - 10.1186/1475-2840-12-82 ID - Fruchart2013 ER - TY - JOUR AU - Shiri-Sverdlov, R. AU - Wouters, K. AU - van Gorp, P. J. PY - 2006 DA - 2006// TI - Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates JO - J Hepatol VL - 44 UR - https://doi.org/10.1016/j.jhep.2005.10.033 DO - 10.1016/j.jhep.2005.10.033 ID - Shiri-Sverdlov2006 ER - TY - JOUR AU - Kersten, S. AU - Seydoux, J. AU - Peters, J. M. AU - Gonzalez, F. J. AU - Desvergne, B. AU - Wahli, W. PY - 1999 DA - 1999// TI - Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting JO - J Clin Invest VL - 103 UR - https://doi.org/10.1172/JCI6223 DO - 10.1172/JCI6223 ID - Kersten1999 ER - TY - JOUR AU - Koteish, A. AU - Diehl, A. M. PY - 2001 DA - 2001// TI - Animal models of steatosis JO - Semin Liver Dis VL - 21 UR - https://doi.org/10.1055/s-2001-12932 DO - 10.1055/s-2001-12932 ID - Koteish2001 ER - TY - JOUR AU - Pawlak, M. AU - Bauge, E. AU - Bourguet, W. PY - 2014 DA - 2014// TI - The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice JO - Hepatology VL - 60 UR - https://doi.org/10.1002/hep.27297 DO - 10.1002/hep.27297 ID - Pawlak2014 ER - TY - JOUR AU - Francque, S. AU - Verrijken, A. AU - Caron, S. PY - 2015 DA - 2015// TI - PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis JO - J Hepatol VL - 63 UR - https://doi.org/10.1016/j.jhep.2015.02.019 DO - 10.1016/j.jhep.2015.02.019 ID - Francque2015 ER - TY - JOUR AU - Liew, C. h. o. o. n. g. -. C. h. i. n. AU - Ma, J. u. n. AU - Tang, H. o. n. g. -. C. h. a. n. g. AU - Zheng, R. u. n. AU - Dempsey, A. d. a. m. A. PY - 2006 DA - 2006// TI - The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool JO - Journal of Laboratory and Clinical Medicine VL - 147 UR - https://doi.org/10.1016/j.lab.2005.10.005 DO - 10.1016/j.lab.2005.10.005 ID - Liew2006 ER - TY - JOUR AU - Crujeiras, A. B. AU - Parra, D. AU - Milagro, F. I. PY - 2008 DA - 2008// TI - Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study JO - Omics VL - 12 UR - https://doi.org/10.1089/omi.2008.0001 DO - 10.1089/omi.2008.0001 ID - Crujeiras2008 ER - TY - JOUR AU - Matthews, D. R. AU - Hosker, J. P. AU - Rudenski, A. S. AU - Naylor, B. A. AU - Teacher, D. F. AU - Tumer, R. C. PY - 1985 DA - 1985// TI - Homeostasis model assessment:insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man JO - Diabetologia VL - 28 UR - https://doi.org/10.1007/BF00280883 DO - 10.1007/BF00280883 ID - Matthews1985 ER - TY - JOUR AU - Fruchart, J. C. PY - 2009 DA - 2009// TI - Peroxisome proliferator-activated receptor-alpha (PPARα): at the crossroads of obesity,  diabetes and cardiovascular disease JO - Atherosclerosis VL - 205 UR - https://doi.org/10.1016/j.atherosclerosis.2009.03.008 DO - 10.1016/j.atherosclerosis.2009.03.008 ID - Fruchart2009 ER - TY - JOUR AU - Guerre-Millo, M. AU - Gervois, P. AU - Raspé, E. PY - 2000 DA - 2000// TI - Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity JO - J Biol Chem VL - 275 UR - https://doi.org/10.1074/jbc.275.22.16638 DO - 10.1074/jbc.275.22.16638 ID - Guerre-Millo2000 ER - TY - JOUR AU - Staels, B. AU - Dallongeville, J. AU - Auwerx, J. AU - Schoonjans, K. AU - Leitersdorf, E. AU - Fruchart, J. C. PY - 1998 DA - 1998// TI - Mechanism of action of fibrtaes on lipid and lipoprotein metabolism JO - Circulation VL - 98 UR - https://doi.org/10.1161/01.CIR.98.19.2088 DO - 10.1161/01.CIR.98.19.2088 ID - Staels1998 ER - TY - JOUR AU - Katsiki, N. AU - Nikolic, D. AU - Montalto, G. AU - Banach, M. AU - Mikhilidis, D. P. AU - Rizzo, M. PY - 2013 DA - 2013// TI - The role of fibrate treatment in dyslipidemia: an overview JO - Curr Pharm Des VL - 19 UR - https://doi.org/10.2174/1381612811319170020 DO - 10.2174/1381612811319170020 ID - Katsiki2013 ER - TY - JOUR AU - Patsouris, D. AU - Müller, M. AU - Kersten, S. PY - 2004 DA - 2004// TI - Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance JO - Curr Opin Investig Drugs VL - 5 ID - Patsouris2004 ER - TY - STD TI - Mirza MS. Obesity, visceral fat, and NAFLD: querying the role of adipokines in the progression of nonalcoholic fatty liver disease. ISRN Gastroenterol. 2011;592404. ID - ref26 ER - TY - JOUR AU - Scicchitano, P. AU - Cameli, M. AU - Maiello, M. PY - 2014 DA - 2014// TI - Nutraceuticals and dyslipidaemia: beyond the common therapeutics JO - J Funct Foods VL - 6 UR - https://doi.org/10.1016/j.jff.2013.12.006 DO - 10.1016/j.jff.2013.12.006 ID - Scicchitano2014 ER - TY - JOUR AU - Zandbergen, F. AU - Plutzky, J. PY - 2007 DA - 2007// TI - PPAR-α in atherosclerosis and inflammation JO - Biochim Biophys Acta VL - 1771 UR - https://doi.org/10.1016/j.bbalip.2007.04.021 DO - 10.1016/j.bbalip.2007.04.021 ID - Zandbergen2007 ER - TY - JOUR AU - Shipman, K. E. AU - Strange, R. C. AU - Ramachandran, S. PY - 2016 DA - 2016// TI - Use of fibrates in the metabolic syndrome: a review JO - World J Diabetes VL - 7 UR - https://doi.org/10.4239/wjd.v7.i5.74 DO - 10.4239/wjd.v7.i5.74 ID - Shipman2016 ER - TY - JOUR AU - Tenenbaum, A. AU - Fisman, E. Z. PY - 2012 DA - 2012// TI - Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction JO - Cardiovasc Diabetol VL - 11 UR - https://doi.org/10.1186/1475-2840-11-125 DO - 10.1186/1475-2840-11-125 ID - Tenenbaum2012 ER - TY - JOUR AU - Liu, X. AU - Zuo, R. AU - Bao, Y. AU - Qu, X. AU - Sun, K. AU - Ying, H. PY - 2017 DA - 2017// TI - Down-regulation of PDK4 is critical for the switch of carbohydrate catabolism during syncytialization of human placental trophoblasts JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-09163-8 DO - 10.1038/s41598-017-09163-8 ID - Liu2017 ER - TY - JOUR AU - Wu, P. AU - Blair, P. V. AU - Sato, J. AU - Jaskiewicz, J. AU - Popov, K. M. AU - Harris, R. A. PY - 2000 DA - 2000// TI - Starvation in-creases the amount of pyruvate dehydrogenase kinase in several mammalian tissues JO - Arch Biochem Biophys VL - 381 UR - https://doi.org/10.1006/abbi.2000.1946 DO - 10.1006/abbi.2000.1946 ID - Wu2000 ER - TY - JOUR AU - Harris, R. A. AU - Huang, B. AU - Wu, P. PY - 2001 DA - 2001// TI - Control of pyruvate dehydrogenase kinase gene expression JO - Adv Enzym Regul VL - 41 UR - https://doi.org/10.1016/S0065-2571(00)00020-0 DO - 10.1016/S0065-2571(00)00020-0 ID - Harris2001 ER - TY - JOUR AU - Jeoung, N. H. AU - Harris, R. A. PY - 2008 DA - 2008// TI - Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice JO - Am J Physiol Endocrinol Metabol VL - 295 UR - https://doi.org/10.1152/ajpendo.00536.2007 DO - 10.1152/ajpendo.00536.2007 ID - Jeoung2008 ER - TY - JOUR AU - Muoio, D. M. AU - Way, J. M. AU - Tanner, C. J. PY - 2002 DA - 2002// TI - Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells JO - Diabetes VL - 51 UR - https://doi.org/10.2337/diabetes.51.4.901 DO - 10.2337/diabetes.51.4.901 ID - Muoio2002 ER - TY - JOUR AU - Djouadi, F. AU - Aubey, F. AU - Schlemmer, D. AU - Bastin, J. PY - 2005 DA - 2005// TI - Peroxisome proliferator activated receptor δ (PPARδ) agonist but not PPAR-α corrects carnitine palmitoyl transferase 2 deficiency in human muscle cells JO - J Clin Endocrinol Metab VL - 90 UR - https://doi.org/10.1210/jc.2004-1936 DO - 10.1210/jc.2004-1936 ID - Djouadi2005 ER - TY - JOUR AU - Abbot, E. L. AU - McCormack, J. G. AU - Reynet, C. AU - Hassall, D. G. AU - Buchan, K. W. AU - Yeaman, S. J. PY - 2005 DA - 2005// TI - Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells JO - FEBS J VL - 272 UR - https://doi.org/10.1111/j.1742-4658.2005.04713.x DO - 10.1111/j.1742-4658.2005.04713.x ID - Abbot2005 ER - TY - JOUR AU - Zhang, M. AU - Zhao, Y. AU - Li, Z. AU - Wang, C. PY - 2018 DA - 2018// TI - Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis JO - Biochem Biophys Res Commun VL - 495 UR - https://doi.org/10.1016/j.bbrc.2017.11.054 DO - 10.1016/j.bbrc.2017.11.054 ID - Zhang2018 ER - TY - JOUR AU - Bouwens, M. AU - Afman, L. A. AU - Müller, M. PY - 2007 DA - 2007// TI - Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increase in fatty acid β-oxidation: functional role of peroxisome proliferator activated receptor α in human peripheral blood mononuclear cells JO - Am J Clin Nutr VL - 86 UR - https://doi.org/10.1093/ajcn/86.5.1515 DO - 10.1093/ajcn/86.5.1515 ID - Bouwens2007 ER - TY - JOUR AU - Houten, S. M. AU - Chegary, M. AU - Te Brinke, H. AU - Wijnen, W. J. AU - Glatz, J. F. C. AU - Luiken, J. J. F. P. PY - 2009 DA - 2009// TI - Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids JO - Cell Mol Life Sci VL - 66 UR - https://doi.org/10.1007/s00018-009-9066-x DO - 10.1007/s00018-009-9066-x ID - Houten2009 ER - TY - JOUR AU - McAndrew, R. P. AU - Wang, Y. AU - Mohsen, A. W. AU - He, M. AU - Vockley, J. AU - Kim, J. P. PY - 2008 DA - 2008// TI - Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase JO - J Biol Chem VL - 283 UR - https://doi.org/10.1074/jbc.M709135200 DO - 10.1074/jbc.M709135200 ID - McAndrew2008 ER - TY - JOUR AU - Simino, L. A. AU - Fante, T. D. AU - Fontana, M. F. PY - 2017 DA - 2017// TI - Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet JO - Nutr Metab (Lond) VL - 14 UR - https://doi.org/10.1186/s12986-017-0168-4 DO - 10.1186/s12986-017-0168-4 ID - Simino2017 ER - TY - JOUR AU - Xia, J. AU - Xin, L. AU - Zhu, W. PY - 2016 DA - 2016// TI - Characterization of long non-coding RNA transcriptome in high-energy diet induced nonalcoholic steatohepatitis minipigs JO - Sci Rep VL - 6 ID - Xia2016 ER -