Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model

Table 2 Metabolic data of experimental groups

	Control 2w	HFHC 2w	Control 4w	HFHC 4w
Body weight(g)	279.7 ± 5.7	279.1 ± 6.2	399.4 ± 11.5	415.0 ± 19.3
Food consumption (g/day)	25.64 ± 0.4	21.97 ± 0.3^***	25.64 ± 0.4	21.97 ± 0.3^***
Serum cholesterol (mg/dl)	26.6 ± 4.3	100.0 ± 3.8^***	34.14 ± 2.4	112.1 ± 4.6^***
Serum HDL (mg/dl)	19.1 ± 2.2	6.2 ± 0.4^***	20.0 ± 1.7	9.3 ± 1.4^***
Serum LDL (mg/dl)	14.6 ± 2.0	93.8 ± 3.9^***	15.2 ± 2.1	102.9 ± 3.6^***
Serum FFA (μM)	63.8 ± 4.0	107.5 ± 9.1^**	98.0 ± 5.8	114.6 ± 4.9^*
Serum MDA (μM)	40.7 ± 2.7	48.9 ± 3.5	42.0 ± 2.8	59.3 ± 5.0^*
Serum CINC-1 (pg/ml)	74.4 ± 11.0	139.1 ± 20.7^*	103.4 ± 12.5	250.6 ± 28.8^***
Serum adiponectin (μg/ml)	10.3 ± 1.2	7.5 ± 0.6^*	8.1 ± 0.6	4.0 ± 0.4^***
Cardiac cholesterol (mg/g tissue)	0.16 ± 0.01	0.19 ± 0.02	0.15 ± 0.009	0.19 ± 0.01^*
Cardiac FFA (mg/g tissue)	25.4 ± 2.6	21.4 ± 1.8	35.7 ± 4.9	28.0 ± 3.5

HFHC high-fat-high cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein, FFA free fatty acids, MDA malondialdehyde, CINC-1 cytokine-induced eutrophil chemo attractant 1. Values were expressed as means±SEM. N = 8 for each group; *p < 0.05, **p < 0.01, ***p < 0.001 vs controls

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