Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy

Table 3 Levels of serum ceramides

Control Group (n = 15)				Sleeve Gastrectomy Group (n = 20)
Ceramide (ng/ml)	Preop	Po Day 1	Po Day 30	Preop	Po Day 1	Po Day 30
C16 CER (d18:1/16:0)	4107,02 ± 461,12	4568,07 ± 265,51	4080,22 ± 503,81	3397,68 ± 217,02	3892,78 ± 401,89	3447,04 ± 183,08
C18 CER (d18:1/18:0)	1312,73 ± 198,25	1498,11 ± 144,02	1103,22 ± 182,85	1188,98 ± 109,14	1361,44 ± 203,41	1213,58 ± 84,05
C20 CER (d18:1/20:0)	1062,13 ± 145,50	1130,25 ± 125,52	983,98 ± 145,01	734,67 ± 79,31	762,52 ± 158,10	650,10 ± 77,73
C22 CER (d18:1/22:0)	6273,70 ± 851,29	6372,18 ± 916,66	7144,98 ± 899,62	5374,87 ± 440,21	3850,60 ± 471,05^a,b	3287,03 ± 371,39^c,d
C24 CER (d18:1/24:0)	19,706,45 ± 1892,46	22,071,44 ± 3507,56	24,340,62 ± 3289,63	20,507,48 ± 2366,78	14,240,44 ± 1709,18^e,f	12,307,39 ± 1400,13^g,h

Values are mean ± SEM. Preop, preoperation; Po, postoperation. C16 Ceramide (d18:1/16:0), N-palmitoyl-D-erythro-sphingosine; C18 Ceramide (d18:1/18:0), N-stearoyl-D-erythro-sphingosine; C20 Ceramide (d18:1/20:0), N-arachidoyl-D-erythro-sphingosine; C22 Ceramide (d18:1/22:0), N-behenoyl-D-erythro-sphingosine; C24 Ceramide (d18:1/24:0), N-lignoceroyl-D-erythro-sphingosine
a, p = 0,014 vs. sleeve gastrectomy preop. Statistical analysis was done by paired t-test
b, p = 0,008 vs. control Po Day 1. Statistical analysis was done by t-test
c, p < 0,001 vs. sleeve gastrectomy preop. Statistical analysis was done by paired t-test
d, p < 0,001 vs. control Po Day 30. Statistical analysis was done by t-test
e, p = 0,005 vs. sleeve gastrectomy preop. Statistical analysis was done by paired t-test
f, p = 0,022 vs. control Po Day 1. Statistical analysis was done by t-test
g, p < 0,001 vs. sleeve gastrectomy preop. Statistical analysis was done by paired t-test
h, p < 0,001 vs control Po Day 30. Statistical analysis was done by t-test

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