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Table 2 The results of meta-analysis for ICAM1 rs5498 and diabetic nephropathy

From: Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis

SNPs

(minor allele)

Genetic Model

subgroup

Number of studies

Numbers

Test of association

Model

Test of heterogeneity

case

control

OR[95% CI]

p-Value

P value

I2 (%)

rs5498

Allelic

total

7

3802

3694

0.93 [0.77, 1.11]

0.41

R

0.003

69

  

Asian

5

2086

1986

0.93 [0.69, 1.25]

0.64

R

0.0008

79

  

Caucasian

2

1716

1708

0.94 [0.82, 1.08]

0.40

F

0.67

0

  

> 1000

1

1324

1240

0.96 [0.82, 1.12]

0.60

NA

NA

NA

  

< 1000

6

2478

2454

0.92 [0.73, 1.17]

0.50

R

0.002

74

  

T1D-DN

2

1716

1708

0.94 [0.82, 1.08]

0.40

F

0.67

0

  

T2D-DN

4

1810

1710

0.87 [0.63, 1.22]

0.43

R

0.001

81

 

Dominant

total

7

1901

1847

0.96 [0.73, 1.27]

0.76

R

0.01

62

  

Asian

5

1043

993

1.12 [0.71, 1.76]

0.63

R

0.01

70

  

Caucasian

2

858

854

0.80 [0.65, 0.99]

0.04

F

0.55

0

  

> 1000

1

662

620

0.83 [0.66, 1.06]

0.14

NA

NA

NA

  

< 1000

6

1239

1227

1.02 [0.70, 1.48]

0.93

R

0.01

67

  

T1D-DN

2

858

854

0.80 [0.65, 0.99]

0.04

F

0.55

0

  

T2D-DN

4

905

855

1.16 [0.63, 2.14]

0.64

R

0.004

77

 

Recessive

total

7

1901

1847

0.83 [0.53, 1.31]

0.43

R

< 0.00001

83

  

Asian

5

1043

993

0.74 [0.38, 1.43]

0.37

R

< 0.0001

85

  

Caucasian

2

858

854

1.11 [0.87, 1.42]

0.41

F

0.91

0

  

> 1000

1

662

620

1.12 [0.85, 1.47]

0.43

NA

NA

NA

  

< 1000

6

1239

1227

0.79 [0.45, 1.38]

0.40

R

< 0.0001

83

  

T1D-DN

2

858

854

1.11 [0.87, 1.42]

0.41

F

0.91

0

  

T2D-DN

4

905

855

0.61 [0.31, 1.17]

0.13

R

0.0009

82

 

Additive

total

7

878

868

0.93 [0.60, 1.44]

0.76

R

0.003

70

  

Asian

5

448

484

0.92 [0.44, 1.92]

0.82

R

0.0006

80

  

Caucasian

2

166

149

0.97 [0.73, 1.29]

0.84

F

0.86

0

  

> 1000

1

141

121

0.96 [0.70, 1.32]

0.80

NA

NA

NA

  

< 1000

6

527

574

0.93 [0.52, 1.68]

0.82

R

0.001

75

  

T1D-DN

2

166

149

0.97 [0.73, 1.29]

0.84

F

0.86

0

  

T2D-DN

4

376

421

0.80 [0.33, 1.92]

0.62

R

0.001

81

  1. Abbreviations: SNP single nucleotide polymorphism, T1D type 1 Diabetes, T2D type 2 Diabetes, DN diabetic nephropathy, ICAM1 intercellular adhesion molecule-1;
  2. F fixed model, R random model, OR odds ratio, CI confidence interval, NA: not available