SNPs (minor allele) | Genetic Model | subgroup | Number of studies | Numbers | Test of association | Model | Test of heterogeneity | |||
---|---|---|---|---|---|---|---|---|---|---|
case | control | OR[95% CI] | p-Value | P value | I2 (%) | |||||
rs5498 | Allelic | total | 7 | 3802 | 3694 | 0.93 [0.77, 1.11] | 0.41 | R | 0.003 | 69 |
Asian | 5 | 2086 | 1986 | 0.93 [0.69, 1.25] | 0.64 | R | 0.0008 | 79 | ||
Caucasian | 2 | 1716 | 1708 | 0.94 [0.82, 1.08] | 0.40 | F | 0.67 | 0 | ||
> 1000 | 1 | 1324 | 1240 | 0.96 [0.82, 1.12] | 0.60 | NA | NA | NA | ||
< 1000 | 6 | 2478 | 2454 | 0.92 [0.73, 1.17] | 0.50 | R | 0.002 | 74 | ||
T1D-DN | 2 | 1716 | 1708 | 0.94 [0.82, 1.08] | 0.40 | F | 0.67 | 0 | ||
T2D-DN | 4 | 1810 | 1710 | 0.87 [0.63, 1.22] | 0.43 | R | 0.001 | 81 | ||
Dominant | total | 7 | 1901 | 1847 | 0.96 [0.73, 1.27] | 0.76 | R | 0.01 | 62 | |
Asian | 5 | 1043 | 993 | 1.12 [0.71, 1.76] | 0.63 | R | 0.01 | 70 | ||
Caucasian | 2 | 858 | 854 | 0.80 [0.65, 0.99] | 0.04 | F | 0.55 | 0 | ||
> 1000 | 1 | 662 | 620 | 0.83 [0.66, 1.06] | 0.14 | NA | NA | NA | ||
< 1000 | 6 | 1239 | 1227 | 1.02 [0.70, 1.48] | 0.93 | R | 0.01 | 67 | ||
T1D-DN | 2 | 858 | 854 | 0.80 [0.65, 0.99] | 0.04 | F | 0.55 | 0 | ||
T2D-DN | 4 | 905 | 855 | 1.16 [0.63, 2.14] | 0.64 | R | 0.004 | 77 | ||
Recessive | total | 7 | 1901 | 1847 | 0.83 [0.53, 1.31] | 0.43 | R | < 0.00001 | 83 | |
Asian | 5 | 1043 | 993 | 0.74 [0.38, 1.43] | 0.37 | R | < 0.0001 | 85 | ||
Caucasian | 2 | 858 | 854 | 1.11 [0.87, 1.42] | 0.41 | F | 0.91 | 0 | ||
> 1000 | 1 | 662 | 620 | 1.12 [0.85, 1.47] | 0.43 | NA | NA | NA | ||
< 1000 | 6 | 1239 | 1227 | 0.79 [0.45, 1.38] | 0.40 | R | < 0.0001 | 83 | ||
T1D-DN | 2 | 858 | 854 | 1.11 [0.87, 1.42] | 0.41 | F | 0.91 | 0 | ||
T2D-DN | 4 | 905 | 855 | 0.61 [0.31, 1.17] | 0.13 | R | 0.0009 | 82 | ||
Additive | total | 7 | 878 | 868 | 0.93 [0.60, 1.44] | 0.76 | R | 0.003 | 70 | |
Asian | 5 | 448 | 484 | 0.92 [0.44, 1.92] | 0.82 | R | 0.0006 | 80 | ||
Caucasian | 2 | 166 | 149 | 0.97 [0.73, 1.29] | 0.84 | F | 0.86 | 0 | ||
> 1000 | 1 | 141 | 121 | 0.96 [0.70, 1.32] | 0.80 | NA | NA | NA | ||
< 1000 | 6 | 527 | 574 | 0.93 [0.52, 1.68] | 0.82 | R | 0.001 | 75 | ||
T1D-DN | 2 | 166 | 149 | 0.97 [0.73, 1.29] | 0.84 | F | 0.86 | 0 | ||
T2D-DN | 4 | 376 | 421 | 0.80 [0.33, 1.92] | 0.62 | R | 0.001 | 81 |