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Table 1 Meta-analysis between the PON1 rs854560 polymorphism and plasma lipid levels

From: Associations of the PON1 rs854560 polymorphism with plasma lipid levels: a meta-analysis

Groups or subgroups Comparisons (Subjects) SMD (95% CI) P Heterogeneity P SMD
TG
 All 42 (12791) − 0.01 (− 0.07–0.06) < 0.01 0.87
 HWE 33 (9805) -0.02 (− 0.10–0.07) < 0.01 0.71
 Male 3 (2920) -0.02 (− 0.09–0.05) 0.42 0.58
 Caucasian 21 (8278) -0.01 (− 0.09–0.07) 0.01 0.81
 Asian 3 (956) 0.22 (0.01–0.41) 0.86 0.05
 Other ethnic 18 (3557) − 0.03 (− 0.18–0.11) < 0.01 0.64
 CHD 5 (802) 0.08 (− 0.20–0.35) 0.01 0.59
 T2DM 3 (693) 0.38 (− 0.61–1.37) 0.01 0.45
 Healthy or control 20 (3268) −0.05 (− 0.19–0.08) < 0.01 0.45
 Case-control 6 (5934) 0.00 (−0.05–0.06) 0.45 0.90
TC
 All 45 (13715) −0.05 (− 0.11–0.02) < 0.01 0.15
 HWE 35 (10411) −0.01 (− 0.06–0.04) 0.29 0.68
 Male 5 (3786) 0.02 (−0.04–0.09) 0.51 0.47
 Caucasian 24 (9202) 0.01 (−0.03–0.05) 0.56 0.68
 Asian 3 (956) 0.03 (−0.18–0.24) 0.63 0.79
 Other ethnic 18 (3557) −0.16 (− 0.33–0.01) < 0.01 0.07
 CHD 6 (1593) 0.04 (−0.06–0.14) 0.61 0.45
 Healthy or control 20 (3305) −0.11 (− 0.26–0.03) < 0.01 0.12
 Case-control 7 (6252) 0.01 (−0.05–0.07) 0.77 0.73
LDL-C
 All 48 (14319) 0.00 (−0.06–0.06) < 0.01 0.91
 HWE 35 (10632) 0.03 (−0.04–0.09) 0.03 0.39
 Male 4 (1002) 0.17 (−0.09–0.43) 0.11 0.20
 Caucasian 24 (9423) 0.06 (0.01–0.12) 0.19 0.03
 Asian 5 (1187) 0.09 (−0.17–0.34) 0.32 0.49
 Other ethnic 19 (3709) −0.11 (− 0.23–0.01) 0.01 0.08
 CHD 5 (1387) 0.09 (−0.04–0.23) 0.28 0.17
 T2DM 4 (486) −0.09 (− 0.34–0.15) 0.85 0.46
 Healthy or control 24 (4919) 0.01 (−0.10–0.13) < 0.01 0.80
 Case-control 6 (6364) 0.05 (−0.06–0.17) 0.03 0.36
HDL-C
 All 57 (19354) −0.15 (− 0.23--0.07) < 0.01 < 0.01
 HWE 41 (15157) −0.04 (− 0.07--0.01) 0.99 0.05
 Male 4 (2518) −0.06 (− 0.14–0.02) 0.95 0.16
 Female 3 (1714) 0.01 (−0.09–0.11) 0.42 0.81
 Caucasian 41 (15269) −0.11 (− 0.20--0.02) < 0.01 0.02
 Asian 6 (1405) −0.13 (− 0.39–0.13) 0.18 0.33
 Other ethnic 11 (2680) −0.32 (− 0.52--0.13) < 0.01 < 0.01
 CHD 7 (2221) −0.03 (− 0.12–0.06) 0.65 0.49
 T2DM 4 (848) −0.35 (− 0.68--0.02) 0.21 0.04
 Healthy or control 29 (8424) −0.11 (− 0.20--0.02) < 0.01 0.02
 Case-control 7 (6582) −0.41 (− 0.77--0.04) < 0.01 0.03
APOA1
 All 22 (13391) −0.67 (− 0.93--0.41) < 0.01 < 0.01
 HWE 20 (12398) −0.74 (−1.03--0.46) < 0.01 < 0.01
 Caucasian 14 (12212) −0.01 (− 0.05–0.03) 0.78 0.66
 Other ethnic 6 (808) −4.46 (−6.69--2.24) < 0.01 < 0.01
 Healthy or control 9 (4375) −0.13 (− 0.42–0.16) < 0.01 0.39
 Case-control 4 (6891) −0.02 (− 0.10–0.05) 0.15 0.56
  1. SMD standardized mean difference, 95% CI 95% confidence interval, HWE Hardy-Weinberg equilibrium, TG triglyceride, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, APOA1 apolipoprotein A-I, CHD coronary heart disease, T2DM type 2 diabetes mellitus