Table 1 Meta-analysis between the PON1 rs854560 polymorphism and plasma lipid levels
From: Associations of the PON1 rs854560 polymorphism with plasma lipid levels: a meta-analysis
Groups or subgroups | Comparisons (Subjects) | SMD (95% CI) | P Heterogeneity | P SMD |
|---|---|---|---|---|
TG | ||||
All | 42 (12791) | − 0.01 (− 0.07–0.06) | < 0.01 | 0.87 |
HWE | 33 (9805) | -0.02 (− 0.10–0.07) | < 0.01 | 0.71 |
Male | 3 (2920) | -0.02 (− 0.09–0.05) | 0.42 | 0.58 |
Caucasian | 21 (8278) | -0.01 (− 0.09–0.07) | 0.01 | 0.81 |
Asian | 3 (956) | 0.22 (0.01–0.41) | 0.86 | 0.05 |
Other ethnic | 18 (3557) | − 0.03 (− 0.18–0.11) | < 0.01 | 0.64 |
CHD | 5 (802) | 0.08 (− 0.20–0.35) | 0.01 | 0.59 |
T2DM | 3 (693) | 0.38 (− 0.61–1.37) | 0.01 | 0.45 |
Healthy or control | 20 (3268) | −0.05 (− 0.19–0.08) | < 0.01 | 0.45 |
Case-control | 6 (5934) | 0.00 (−0.05–0.06) | 0.45 | 0.90 |
TC | ||||
All | 45 (13715) | −0.05 (− 0.11–0.02) | < 0.01 | 0.15 |
HWE | 35 (10411) | −0.01 (− 0.06–0.04) | 0.29 | 0.68 |
Male | 5 (3786) | 0.02 (−0.04–0.09) | 0.51 | 0.47 |
Caucasian | 24 (9202) | 0.01 (−0.03–0.05) | 0.56 | 0.68 |
Asian | 3 (956) | 0.03 (−0.18–0.24) | 0.63 | 0.79 |
Other ethnic | 18 (3557) | −0.16 (− 0.33–0.01) | < 0.01 | 0.07 |
CHD | 6 (1593) | 0.04 (−0.06–0.14) | 0.61 | 0.45 |
Healthy or control | 20 (3305) | −0.11 (− 0.26–0.03) | < 0.01 | 0.12 |
Case-control | 7 (6252) | 0.01 (−0.05–0.07) | 0.77 | 0.73 |
LDL-C | ||||
All | 48 (14319) | 0.00 (−0.06–0.06) | < 0.01 | 0.91 |
HWE | 35 (10632) | 0.03 (−0.04–0.09) | 0.03 | 0.39 |
Male | 4 (1002) | 0.17 (−0.09–0.43) | 0.11 | 0.20 |
Caucasian | 24 (9423) | 0.06 (0.01–0.12) | 0.19 | 0.03 |
Asian | 5 (1187) | 0.09 (−0.17–0.34) | 0.32 | 0.49 |
Other ethnic | 19 (3709) | −0.11 (− 0.23–0.01) | 0.01 | 0.08 |
CHD | 5 (1387) | 0.09 (−0.04–0.23) | 0.28 | 0.17 |
T2DM | 4 (486) | −0.09 (− 0.34–0.15) | 0.85 | 0.46 |
Healthy or control | 24 (4919) | 0.01 (−0.10–0.13) | < 0.01 | 0.80 |
Case-control | 6 (6364) | 0.05 (−0.06–0.17) | 0.03 | 0.36 |
HDL-C | ||||
All | 57 (19354) | −0.15 (− 0.23--0.07) | < 0.01 | < 0.01 |
HWE | 41 (15157) | −0.04 (− 0.07--0.01) | 0.99 | 0.05 |
Male | 4 (2518) | −0.06 (− 0.14–0.02) | 0.95 | 0.16 |
Female | 3 (1714) | 0.01 (−0.09–0.11) | 0.42 | 0.81 |
Caucasian | 41 (15269) | −0.11 (− 0.20--0.02) | < 0.01 | 0.02 |
Asian | 6 (1405) | −0.13 (− 0.39–0.13) | 0.18 | 0.33 |
Other ethnic | 11 (2680) | −0.32 (− 0.52--0.13) | < 0.01 | < 0.01 |
CHD | 7 (2221) | −0.03 (− 0.12–0.06) | 0.65 | 0.49 |
T2DM | 4 (848) | −0.35 (− 0.68--0.02) | 0.21 | 0.04 |
Healthy or control | 29 (8424) | −0.11 (− 0.20--0.02) | < 0.01 | 0.02 |
Case-control | 7 (6582) | −0.41 (− 0.77--0.04) | < 0.01 | 0.03 |
APOA1 | ||||
All | 22 (13391) | −0.67 (− 0.93--0.41) | < 0.01 | < 0.01 |
HWE | 20 (12398) | −0.74 (−1.03--0.46) | < 0.01 | < 0.01 |
Caucasian | 14 (12212) | −0.01 (− 0.05–0.03) | 0.78 | 0.66 |
Other ethnic | 6 (808) | −4.46 (−6.69--2.24) | < 0.01 | < 0.01 |
Healthy or control | 9 (4375) | −0.13 (− 0.42–0.16) | < 0.01 | 0.39 |
Case-control | 4 (6891) | −0.02 (− 0.10–0.05) | 0.15 | 0.56 |