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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Fig. 2

USF1 deficiency improves acceptor capacity of serum and HDL particles, enriched with phospholipids (PL). (a) Cholesterol efflux from THP-1 macrophages to serum derived from Usf1+/+ and Usf1-/- mice. n=5 for each column. Serum samples from five individual Usf1+/+ and Usf1-/- mice were analyzed in two independent experiments. (b) Cholesterol efflux from THP-1 macrophages to HDL particles derived from Usf1+/+ (n=7 mice, pooled HDL) and Usf1-/- mice (n=8 mice, pooled HDL), n=6 parallel wells for THP-1 cells in two independent experiments. (c) Mass composition (%) of HDL particles isolated from Usf1+/+ and Usf1-/- mice. n=11/9. (d) HDL particle content (mmol/L for lipid and g/L for APOA1), n=11/9. *** P < 0.001, ** P < 0.01, * P < 0.05, for comparisons between groups

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