Fig. 2From: USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophagesUSF1 deficiency improves acceptor capacity of serum and HDL particles, enriched with phospholipids (PL). (a) Cholesterol efflux from THP-1 macrophages to serum derived from Usf1+/+ and Usf1-/- mice. n=5 for each column. Serum samples from five individual Usf1+/+ and Usf1-/- mice were analyzed in two independent experiments. (b) Cholesterol efflux from THP-1 macrophages to HDL particles derived from Usf1+/+ (n=7 mice, pooled HDL) and Usf1-/- mice (n=8 mice, pooled HDL), n=6 parallel wells for THP-1 cells in two independent experiments. (c) Mass composition (%) of HDL particles isolated from Usf1+/+ and Usf1-/- mice. n=11/9. (d) HDL particle content (mmol/L for lipid and g/L for APOA1), n=11/9. *** P < 0.001, ** P < 0.01, * P < 0.05, for comparisons between groupsBack to article page