Skip to main content

Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Fig. 3 | Lipids in Health and Disease

Fig. 3

From: USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages

Fig. 3

USF1 deficiency attenuates LPS-induced proinflammatory responses of macrophages and protects against inflammation-induced cholesterol accumulation. (a) Cholesterol content of mouse peritoneal macrophages incubated without or with LPS. n=4/5/9/8 parallel wells in two independent experiments. (b) Expression of Nfkb1 and Nfkb2 (NF-κB) in peritoneal macrophages in the absence of LPS. n=4/4. (c) Secretion of MCP-1 from THP-1 macrophages +/- acLDL, n=6 from 2 independent experiments. (d) Secretion of IL-1β from THP-1 macrophages +/- acLDL, n=6 from 2 independent experiments. (e) Gene expression of cholesterol transporters relevant for cholesterol uptake in THP-1 macrophages in the absence of LPS. n=4 in each column. *** P < 0.001, ** P < 0.01, * P < 0.05, for comparisons between groups

Back to article page