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Table 1 Body weight/ adipose tissue weight, biochemistry and other biomarkers

From: Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue

 

VEH

DEX

VHF

DHF

H1

H2

H1 × H2

Weight (g)

666.33 ± 18.70

668.00 ± 29.50

763.33 ± 45.42

942.17 ± 61.84*#†

p = 0.045

p < 0.001

p = 0.048

Retroperitoneal fat (g)

13.96 ± 1.77

13.17 ± 1.36

28.95 ± 4.53*

48.50 ± 4.47*#†

p = 0.012

p < 0.001

p = 0.007

Subcutaneous fat (g)

26.78 ± 2.65

30.72 ± 3.27

56.42 ± 7.36

79.25 ± 9.91

NS

p < 0.001

NS

Mesenteric fat (g)

5.76 ± 0.93

5.58 ± 0.68

9.17 ± 1.54

13.91 ± 2.12

NS

p = 0.001

NS

Epididymal fat (g)

7.35 ± 0.41

8.05 ± 0.17

18.05 ± 1.46

21.42 ± 1.65

NS

p < 0.001

NS

AST (U/L)

128.25 ± 45.53

97.40 ± 9.37

146.33 ± 11.32

248.50 ± 28.92#†

NS

p = 0.004

p = 0.018

ALT (U/L)

85.75 ± 52.12

44.80 ± 2.46

78.17 ± 11.58

156.67 ± 9.65#†

NS

p = 0.026

p = 0.012

T-Cholesterol (mg/dL)

88.50 ± 10.74

107.40 ± 17.72

81.17 ± 5.34

63.50 ± 5.49

NS

p = 0.025

NS

Triglyceride (mg/dL)

104.75 ± 5.20

136.60 ± 30.76

54.00 ± 6.67

57.67 ± 8.64

NS

p = 0.001

NS

ALK-P (U/L)

65.50 ± 11.30

55.80 ± 3.73

49.00 ± 4.68

62.67 ± 7.54

NS

NS

NS

Leptin (ng/ml)

2.66 ± 0.30

2.58 ± 0.99

4.62 ± 0.48

4.39 ± 0.33

NS

p < 0.001

NS

TNFα (pg/ml)

7.81 ± 0.48

8.68 ± 0.18

11.29 ± 0.14

11.36 ± 0.54

NS

p < 0.001

NS

VEGF (pg/ml)

15.21 ± 0.24

15.51 ± 0.29

16.53 ± 0.23

16.47 ± 0.28

NS

p < 0.001

NS

  1. AST aspartate transaminase, ALT alanine aminotransferase, ALK-P Alkaline phosphatase, VEGF vascular endothelial growth factor, VEH prenatal saline vehicle /postnatal normal diet group, DEX prenatal dexamethasone exposure /postnatal normal diet group, VHF prenatal saline vehicle /postnatal high fat diet group, DHF prenatal dexamethasone exposure /postnatal high-fat diet group. * as compared with VEH, p < 0.05; # as compared with DEX, p < 0.05; † as compared with VHF, p < 0.05