TY - STD TI - Hussain G, Schmitt F, Loeffler J-P, de Aguilar J-LG. Fatting the brain: a brief of recent research. Front Cell Neurosci. 2013;7:1–14. Available from: http://journal.frontiersin.org/article/10.3389/fncel.2013.00144/abstract. UR - http://journal.frontiersin.org/article/10.3389/fncel.2013.00144/abstract ID - ref1 ER - TY - STD TI - Ecker C, Bookheimer SY, Murphy DGM. Neuroimaging in autism spectrum disorder: Brain structure and function across the lifespan. Lancet Neurol. 2015:1121–34. ID - ref2 ER - TY - STD TI - Adibhatla RM, Hatcher JF. Altered Lipid Metabolism in Brain Injury and Disorders. Lipids Health Dis. Dordrecht: Springer Netherlands; 2008. p. 241–68. Available from: http://link.springer.com/10.1007/978-1-4020-8831-5_9. UR - http://link.springer.com/10.1007/978-1-4020-8831-5_9 ID - ref3 ER - TY - STD TI - Aureli M, Grassi S, Prioni S, Sonnino S, Prinetti A. Lipid membrane domains in the brain. Biochim. Biophys. Acta - Mol. Cell Biol. Lipids. Elsevier B.V. 2015:1006–16. ID - ref4 ER - TY - STD TI - Sastry PS. Lipids of nervous tissue: composition and metabolism. Prog Lipid Res. 1985:69–176. ID - ref5 ER - TY - STD TI - Luchtman DW, Song C. Cognitive enhancement by omega-3 fatty acids from child-hood to old age: findings from animal and clinical studies. Neuropharmacology. 2013;64:550–65. Available from: https://doi.org/10.1016/j.neuropharm.2012.07.019. ID - ref6 ER - TY - STD TI - Cermenati G, Mitro N, Audano M, Melcangi RC, Crestani M, De Fabiani E, et al. Lipids in the nervous system: from biochemistry and molecular biology to patho-physiology. Biochim Biophys Acta - Mol Cell Biol Lipids 2015;1851:51–60. ID - ref7 ER - TY - STD TI - Korade Z, Kenworthy AK. Lipid rafts, cholesterol, and the brain. Neuropharmacology. 2008:55(8):1265–73. ID - ref8 ER - TY - JOUR AU - Zhang, J. AU - Liu, Q. PY - 2015 DA - 2015// TI - Cholesterol metabolism and homeostasis in the brain JO - Protein Cell Springer VL - 6 UR - https://doi.org/10.1007/s13238-014-0131-3 DO - 10.1007/s13238-014-0131-3 ID - Zhang2015 ER - TY - JOUR AU - Hardie, R. C. AU - Muallem, S. PY - 2009 DA - 2009// TI - Lipids in Ca2+ signalling-an introduction JO - Cell Calcium VL - 45 UR - https://doi.org/10.1016/j.ceca.2009.03.016 DO - 10.1016/j.ceca.2009.03.016 ID - Hardie2009 ER - TY - JOUR AU - Ridone, P. AU - Grage, S. L. AU - Patkunarajah, A. AU - Battle, A. R. AU - Ulrich, A. S. AU - Martinac, B. PY - 2017 DA - 2017// TI - “Force-from-lipids” gating of mechanosensitive channels modulated by PUFAs JO - J Mech Behav Biomed Mater Netherlands VL - 79 UR - https://doi.org/10.1016/j.jmbbm.2017.12.026 DO - 10.1016/j.jmbbm.2017.12.026 ID - Ridone2017 ER - TY - STD TI - London E. Insights into lipid raft structure and formation from experiments in model membranes. Curr Opin Struct Biol. 2002:12(4):480–6. ID - ref12 ER - TY - STD TI - Saher G, Quintes S, Nave KA. Cholesterol: a novel regulatory role in myelin formation. Neuroscientist. 2011:79–93. ID - ref13 ER - TY - STD TI - Schmitt F, Hussain G, Dupuis L, Loeffler J-P, Henriques A. A plural role for lipids in motor neuron diseases: energy, signaling and structure. Front Cell Neurosci. 2014;8:25. Available from: http://journal.frontiersin.org/article/10.3389/fncel.2014.00025/abstract UR - http://journal.frontiersin.org/article/10.3389/fncel.2014.00025/abstract ID - ref14 ER - TY - STD TI - Björkhem I, Meaney S, Brain Cholesterol FAM. Long secret life behind a barrier. Arterioscler Thromb Vasc Biol. 2004:806–15. ID - ref15 ER - TY - JOUR AU - Zuo, H. AU - Wang, R. AU - Jiang, D. AU - Fang, D. PY - 2017 DA - 2017// TI - Determining the composition of active Cholesterol in the plasma membrane of single cells by using Electrochemiluminescence JO - ChemElectroChem VL - 4 UR - https://doi.org/10.1002/celc.201600738 DO - 10.1002/celc.201600738 ID - Zuo2017 ER - TY - JOUR AU - Segatto, M. AU - Giovanni, A. AU - Marino, M. AU - Pallottini, V. PY - 2013 DA - 2013// TI - Analysis of the protein network of cholesterol homeostasis in different brain regions: an age and sex dependent perspective JO - J Cell Physiol VL - 228 UR - https://doi.org/10.1002/jcp.24315 DO - 10.1002/jcp.24315 ID - Segatto2013 ER - TY - JOUR AU - Cunningham, D. AU - DeBarber, A. E. AU - Bir, N. AU - Binkley, L. AU - Merkens, L. S. AU - Steiner, R. D. PY - 2015 DA - 2015// TI - Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development JO - Hum Mol Genet VL - 24 UR - https://doi.org/10.1093/hmg/ddv042 DO - 10.1093/hmg/ddv042 ID - Cunningham2015 ER - TY - JOUR AU - Goritz, C. AU - Mauch, D. H. AU - Pfrieger, F. W. PY - 2005 DA - 2005// TI - Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron JO - Mol Cell Neurosci VL - 29 UR - https://doi.org/10.1016/j.mcn.2005.02.006 DO - 10.1016/j.mcn.2005.02.006 ID - Goritz2005 ER - TY - STD TI - Liu JP, Tang Y, Zhou S, Toh BH, McLean C, Li H. Cholesterol involvement in the pathogenesis of neurodegenerative diseases. Mol Cell Neurosci Elsevier Inc.; 2010:43(1):33–42. ID - ref20 ER - TY - STD TI - Vance JE. Lipid imbalance in the neurological disorder, Niemann-pick C disease. FEBS Lett. 2006:5518–24. ID - ref21 ER - TY - JOUR AU - Spady, D. K. AU - Dietschy, J. M. PY - 1983 DA - 1983// TI - Sterol synthesis in vivo in 18 tissues of the squirrel monkey, Guinea pig, rabbit, hamster, and rat JO - J Lipid Res VL - 24 ID - Spady1983 ER - TY - JOUR AU - Lund, E. G. AU - Xie, C. AU - Kotti, T. AU - Turley, S. D. AU - Dietschy, J. M. AU - Russell, D. W. PY - 2003 DA - 2003// TI - Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover JO - J Biol Chem VL - 278 UR - https://doi.org/10.1074/jbc.M303415200 DO - 10.1074/jbc.M303415200 ID - Lund2003 ER - TY - JOUR AU - Pfrieger, F. W. PY - 2003 DA - 2003// TI - Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes? JO - BioEssays VL - 25 UR - https://doi.org/10.1002/bies.10195 DO - 10.1002/bies.10195 ID - Pfrieger2003 ER - TY - STD TI - Turley SD, Burns DK, Rosenfeld CR, Dietschy JM. Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep. J Lipid Res. 1996;37:1953–61. ID - ref25 ER - TY - JOUR AU - Brecht, W. J. AU - Harris, F. M. AU - Chang, S. AU - Tesseur, I. AU - Yu, G. -. Q. AU - Xu, Q. PY - 2004 DA - 2004// TI - Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice JO - J Neurosci VL - 24 UR - https://doi.org/10.1523/JNEUROSCI.4315-03.2004 DO - 10.1523/JNEUROSCI.4315-03.2004 ID - Brecht2004 ER - TY - STD TI - Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer’s disease. Proc Natl Acad Sci. 2006;103:5644–51. Available from: http://www.pnas.org/cgi/doi/10.1073/pnas.0600549103. UR - http://www.pnas.org/cgi/doi/10.1073/pnas.0600549103 ID - ref27 ER - TY - STD TI - Kıray H, Lindsay SL, Hosseinzadeh S, Barnett SC. The multifaceted role of astrocytes in regulating myelination. Exp Neurol. 2016:541–9. ID - ref28 ER - TY - JOUR AU - Karten, B. AU - Hayashi, H. AU - Francis, G. A. AU - Campenot, R. B. AU - Vance, D. E. AU - Vance, J. E. PY - 2005 DA - 2005// TI - Generation and function of astroglial lipoproteins from Niemann–pick type C1-deficient mice JO - Biochem J VL - 387 UR - https://doi.org/10.1042/BJ20041694 DO - 10.1042/BJ20041694 ID - Karten2005 ER - TY - JOUR AU - Hayashi, H. AU - Campenot, R. B. AU - Vance, D. E. AU - Vance, J. E. PY - 2004 DA - 2004// TI - Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures JO - J Biol Chem VL - 279 UR - https://doi.org/10.1074/jbc.M313828200 DO - 10.1074/jbc.M313828200 ID - Hayashi2004 ER - TY - STD TI - Steward MM, Sridhar A, Meyer JS. Neural Regeneration. Curr Top Microbiol Immunol. 2012:163–91. ID - ref31 ER - TY - JOUR AU - Lemmon, V. P. AU - Goldberg, J. L. PY - 2009 DA - 2009// TI - Intrinsic axon Regeneration ability JO - Science (80- ) VL - 1007 ID - Lemmon2009 ER - TY - STD TI - Schwab ME, Strittmatter SM. Nogo limits neural plasticity and recovery from injury. Curr Opin Neurobiol. 2014:27:53–60. ID - ref33 ER - TY - STD TI - Park WJ, Park JW. The effect of altered sphingolipid acyl chain length on various disease models. Biol Chem. 2015:396(6-7):693–705. ID - ref34 ER - TY - JOUR AU - Mauch, D. H. AU - Nägier, K. AU - Schumacher, S. AU - Göritz, C. AU - Müller, E. C. AU - Otto, A. PY - 2001 DA - 2001// TI - CNS synaptogenesis promoted by glia-derived cholesterol. Science (80- ). American association for the JO - Advancement of Science VL - 294 UR - https://doi.org/10.1126/science.294.5545.1354 DO - 10.1126/science.294.5545.1354 ID - Mauch2001 ER - TY - JOUR AU - Ko, M. AU - Zou, K. AU - Minagawa, H. AU - Yu, W. AU - Gong, J. S. AU - Yanagisawa, K. PY - 2005 DA - 2005// TI - Cholesterol-mediated neurite outgrowth is differently regulated between cortical and hippocampal neurons JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M509164200 DO - 10.1074/jbc.M509164200 ID - Ko2005 ER - TY - JOUR AU - Pooler, A. M. AU - Xi, S. C. AU - Wurtman, R. J. PY - 2006 DA - 2006// TI - The 3-hydroxy-3-methylglutaryl co-enzyme a reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons JO - J Neurochem VL - 97 UR - https://doi.org/10.1111/j.1471-4159.2006.03763.x DO - 10.1111/j.1471-4159.2006.03763.x ID - Pooler2006 ER - TY - STD TI - Suzuki S, Kiyosue K, Hazama S, Ogura A, Kashihara M, Hara T, et al. Brain-Derived Neurotrophic Factor Regulates Cholesterol Metabolism for Synapse Development. J Neurosci. 2007;27:6417–27. Available from: http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.0690-07.2007. UR - http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.0690-07.2007 ID - ref38 ER - TY - STD TI - Sebastião AM, Colino-Oliveira M, Assaife-Lopes N, Dias RB, Ribeiro JA. Lipid rafts, synaptic transmission and plasticity: impact in age-related neurodegenerative diseases. Neuropharmacology. 2013:64:97–107. ID - ref39 ER - TY - STD TI - Panagopoulos GN, Megaloikonomos PD, Mavrogenis AF. The present and future for peripheral nerve Regeneration. Orthopedics. SLACK Incorporated. 2017;40:e141–56. Available from: http://www.healio.com/doiresolver?doi=10.3928/01477447-20161019-01. UR - http://www.healio.com/doiresolver?doi=10.3928/01477447-20161019-01 ID - ref40 ER - TY - JOUR AU - Mar, F. M. AU - Silva, T. F. AU - Morgado, M. M. AU - Rodrigues, L. G. AU - Rodrigues, D. AU - Pereira, M. I. L. PY - 2016 DA - 2016// TI - Myelin lipids inhibit axon Regeneration following spinal cord injury: a novel perspective for therapy JO - Mol Neurobiol VL - 53 UR - https://doi.org/10.1007/s12035-014-9072-3 DO - 10.1007/s12035-014-9072-3 ID - Mar2016 ER - TY - JOUR AU - Goodrum, J. F. AU - Brown, J. C. AU - Fowler, K. A. AU - Bouldin, T. W. PY - 2000 DA - 2000// TI - Axonal regeneration, but not myelination, is partially dependent on local cholesterol reutilization in regenerating nerve JO - J Neuropathol Exp Neurol VL - 59 UR - https://doi.org/10.1093/jnen/59.11.1002 DO - 10.1093/jnen/59.11.1002 ID - Goodrum2000 ER - TY - STD TI - Südhof TC. THE SYNAPTIC VESICLE CYCLE. Annu Rev Neurosci. 2004;27:509–47. Available from: http://www.annualreviews.org/doi/10.1146/annurev.neuro.26.041002.131412. UR - http://www.annualreviews.org/doi/10.1146/annurev.neuro.26.041002.131412 ID - ref43 ER - TY - JOUR AU - Ignatius, M. J. AU - Gebicke-harter, P. J. AU - Skene, J. H. P. AU - Schillingt, J. W. AU - Weisgrabert, K. H. AU - Mahleyt, R. W. PY - 1986 DA - 1986// TI - Expression of apolipoprotein E during nerve degeneration and regeneration JO - Proc Natl Acad Sci U S A VL - 83 UR - https://doi.org/10.1073/pnas.83.4.1125 DO - 10.1073/pnas.83.4.1125 ID - Ignatius1986 ER - TY - STD TI - Skene JH, Shooter EM. Denervated sheath cells secrete a new protein after nerve injury. Proc Natl Acad Sci USA. 1983;80:4169–73. Available from: https://doi.org/10.1073/pnas.80.13.4169. ID - ref45 ER - TY - JOUR AU - Boyles, J. K. AU - Zoellner, C. D. AU - Anderson, L. J. AU - Kosik, L. M. AU - Pitas, R. E. AU - Weisgraber, K. H. PY - 1989 DA - 1989// TI - A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve JO - J Clin Invest VL - 83 UR - https://doi.org/10.1172/JCI113943 DO - 10.1172/JCI113943 ID - Boyles1989 ER - TY - JOUR AU - Goodrum, J. F. AU - Fowler, K. A. AU - Hostettler, J. D. AU - Toews, A. D. PY - 2000 DA - 2000// TI - Peripheral nerve regeneration and cholesterol reutilization are normal in the low-density lipoprotein receptor knockout mouse JO - J Neurosci Res VL - 59 UR - https://doi.org/3.0.CO;2-P DO - 3.0.CO;2-P ID - Goodrum2000 ER - TY - JOUR AU - Goodrum, J. F. AU - Pentchev, P. G. PY - 1997 DA - 1997// TI - Cholesterol reutilization during myelination of regenerating PNS axons is impaired in niemann-pick disease type C mice JO - J Neurosci Res VL - 49 UR - https://doi.org/3.0.CO;2-V DO - 3.0.CO;2-V ID - Goodrum1997 ER - TY - STD TI - Hussain G, Rasul A, Anwar H, Aziz N, Razzaq A, Wei W, et al. Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders. Int J Biol Sci. 2018;14:341–57. Available from: http://www.ijbs.com/v14p0341.htm. UR - http://www.ijbs.com/v14p0341.htm ID - ref49 ER - TY - STD TI - Nhan HS, Chiang K, Koo EH. The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol. 2015:129(1):1–19. ID - ref50 ER - TY - JOUR AU - Popugaeva, E. AU - Pchitskaya, E. AU - Bezprozvanny, I. PY - 2018 DA - 2018// TI - Dysregulation of intracellular calcium signaling in Alzheimer’s disease JO - Antioxid Redox Signal United States VL - 29 UR - https://doi.org/10.1089/ars.2018.7506 DO - 10.1089/ars.2018.7506 ID - Popugaeva2018 ER - TY - JOUR AU - Kodis, E. J. AU - Choi, S. AU - Swanson, E. AU - Ferreira, G. AU - Bloom, G. S. PY - 2018 DA - 2018// TI - N-methyl-D-aspartate receptor–mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer’s disease JO - Alzheimers Dement VL - 14 UR - https://doi.org/10.1016/j.jalz.2018.05.017 DO - 10.1016/j.jalz.2018.05.017 ID - Kodis2018 ER - TY - JOUR AU - Oveisgharan, S. AU - Buchman, A. S. AU - Yu, L. AU - Farfel, J. AU - Hachinski, V. AU - Gaiteri, C. PY - 2018 DA - 2018// TI - APOE ϵ2ϵ4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults JO - Neurology VL - 90 UR - https://doi.org/10.1212/WNL.0000000000005677 DO - 10.1212/WNL.0000000000005677 ID - Oveisgharan2018 ER - TY - JOUR AU - Gamba, P. AU - Testa, G. AU - Sottero, B. AU - Gargiulo, S. AU - Poli, G. AU - Leonarduzzi, G. PY - 2012 DA - 2012// TI - The link between altered cholesterol metabolism and Alzheimer’s disease JO - Ann N Y Acad Sci VL - 1259 UR - https://doi.org/10.1111/j.1749-6632.2012.06513.x DO - 10.1111/j.1749-6632.2012.06513.x ID - Gamba2012 ER - TY - STD TI - Wood WG, Li L, Müller WE, Eckert GP. Cholesterol as a causative factor in Alzheimer’s disease: a debatable hypothesis. J Neurochem. 2014:559–72. ID - ref55 ER - TY - STD TI - Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, et al. Endosomal-lysosomal Cholesterol Sequestration by U18666A Differentially Regulates APP Metabolism in Normal and APP Overexpressing Cells. Mol Cell Biol. 2018;MCB.00529–17. Available from: http://mcb.asm.org/lookup/doi/10.1128/MCB.00529-17. UR - http://mcb.asm.org/lookup/doi/10.1128/MCB.00529-17 ID - ref56 ER - TY - JOUR AU - Shang, J. AU - Yamashita, T. AU - Fukui, Y. AU - Song, D. AU - Li, X. AU - Zhai, Y. PY - 2018 DA - 2018// TI - Different associations of plasma biomarkers in alzheimer’s disease, mild cognitive impairment, vascular dementia, and ischemic stroke JO - J Clin Neurol VL - 14 UR - https://doi.org/10.3988/jcn.2018.14.1.29 DO - 10.3988/jcn.2018.14.1.29 ID - Shang2018 ER - TY - STD TI - Catapano AL. Dyslipidaemias in 2017: Atherogenic lipoproteins as treatment targets. Nat Rev Cardiol. 2018;15:75–6. Available from: http://www.nature.com/doifinder/10.1038/nrcardio.2017.221. UR - http://www.nature.com/doifinder/10.1038/nrcardio.2017.221 ID - ref58 ER - TY - STD TI - Markopoulou K, Compta Y. Cerebrospinal fluid levels of alpha-synuclein in Parkinson's disease: another long and winding road. Park Relat Disord. 2018;49:1–3. ID - ref59 ER - TY - JOUR AU - Galvagnion, C. AU - Buell, A. K. AU - Meisl, G. AU - Michaels, T. C. T. AU - Vendruscolo, M. AU - Knowles, T. P. J. PY - 2015 DA - 2015// TI - Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation JO - Nat Chem Biol VL - 11 UR - https://doi.org/10.1038/nchembio.1750 DO - 10.1038/nchembio.1750 ID - Galvagnion2015 ER - TY - STD TI - Doria M, Maugest L, Moreau T, Lizard G, Vejux A. Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson’s disease. Free Radic Biol Med. 2016;101:393–400. ID - ref61 ER - TY - STD TI - Paul R, Choudhury A, Borah A, Cholesterol - A. Putative endogenous contributor towards Parkinson’s disease. Neurochem. Int Elsevier Ltd. 2015:125–33. ID - ref62 ER - TY - BOOK AU - Hu, G. PY - 2010 DA - 2010// TI - Total cholesterol and the risk of parkinson’s disease: A review for some new findings PB - Dis CY - Parkinsons ID - Hu2010 ER - TY - JOUR AU - Paul, R. AU - Dutta, A. AU - Phukan, B. C. AU - Mazumder, M. K. AU - Justin-Thenmozhi, A. AU - Manivasagam, T. PY - 2018 DA - 2018// TI - Accumulation of Cholesterol and homocysteine in the nigrostriatal pathway of Brain contributes to the dopaminergic neurodegeneration in mice JO - Neuroscience VL - 388 UR - https://doi.org/10.1016/j.neuroscience.2018.07.041 DO - 10.1016/j.neuroscience.2018.07.041 ID - Paul2018 ER - TY - STD TI - Pfister E, Dinardo N, Mondo E, Borel F, Conroy F, Fraser C, et al. Artificial miRNAs reduce human mutant Huntingtin throughout the striatum in a transgenic sheep model of Huntington’s disease. Hum Gene Ther. 2017;hum.2017.199. Available from: http://online.liebertpub.com/doi/10.1089/hum.2017.199. UR - http://online.liebertpub.com/doi/10.1089/hum.2017.199 ID - ref65 ER - TY - JOUR AU - Shankaran, M. AU - Paolo, E. AU - Leoni, V. AU - Caccia, C. AU - Ferrari Bardile, C. AU - Mohammed, H. PY - 2017 DA - 2017// TI - Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington’s disease: a cross-validation study in Q175 knock-in mice JO - Neurobiol Dis VL - 98 UR - https://doi.org/10.1016/j.nbd.2016.11.013 DO - 10.1016/j.nbd.2016.11.013 ID - Shankaran2017 ER - TY - STD TI - Valenza M, Birolini G, Paolo E Di, Vezzoli E, Maniezzi C, Talpo F, et al. I14 Translational potential of cholesterol supplementation-based strategies for huntington’s disease. J Neurol Neurosurg Psychiatry. 2018;89:A93. Available from: https://jnnp.bmj.com/content/89/Suppl_1/A93.2. UR - https://jnnp.bmj.com/content/89/Suppl_1/A93.2 ID - ref67 ER - TY - JOUR AU - Carlén, M. AU - Meletis, K. AU - Siegle, J. H. AU - Cardin, J. A. AU - Futai, K. AU - Vierling-Claassen, D. PY - 2012 DA - 2012// TI - A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior JO - Mol Psychiatry Nature Publishing Group VL - 17 UR - https://doi.org/10.1038/mp.2011.31 DO - 10.1038/mp.2011.31 ID - Carlén2012 ER - TY - JOUR AU - Yasuda, K. AU - Yoshida, T. AU - Kashiwagi, M. AU - Nakagawa, N. AU - Michikawa, T. AU - Tanaka, M. PY - 2017 DA - 2017// TI - Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults JO - Transl Psychiatry Nature Publishing Group VL - 7 UR - https://doi.org/10.1038/tp.2017.19 DO - 10.1038/tp.2017.19 ID - Yasuda2017 ER - TY - STD TI - Uzunova G, Hollander E, Shepherd J. The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: autism Spectrum disorders and fragile X syndrome. Curr Neuropharmacol. 2014;12:71–98. Available from: http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1570-159X&volume=12&issue=1&spage=71. UR - http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1570-159X&volume=12&issue=1&spage=71 ID - ref70 ER - TY - STD TI - Paul SM, Doherty JJ, Robichaud AJ, Belfort GM, Chow BY, Hammond RS, et al. The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors. J Neurosci. 2013;33:17290–300. Available from: http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2619-13.2013. UR - http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2619-13.2013 ID - ref71 ER - TY - JOUR AU - Linsenbardt, A. J. AU - Taylor, A. AU - Emnett, C. M. AU - Doherty, J. J. AU - Krishnan, K. AU - Covey, D. F. PY - 2014 DA - 2014// TI - Different oxysterols have opposing actions at N-methyl-d-aspartate receptors JO - Neuropharmacology VL - 85 UR - https://doi.org/10.1016/j.neuropharm.2014.05.027 DO - 10.1016/j.neuropharm.2014.05.027 ID - Linsenbardt2014 ER - TY - STD TI - Sun M-Y, Izumi Y, Benz A, Zorumski CF, Mennerick S. Endogenous 24 S -hydroxycholesterol modulates NMDAR-mediated function in hippocampal slices. J Neurophysiol. 2016;115:1263–72. Available from: http://jn.physiology.org/lookup/doi/10.1152/jn.00890.2015. UR - http://jn.physiology.org/lookup/doi/10.1152/jn.00890.2015 ID - ref73 ER - TY - STD TI - Benn M, Nordestgaard BG, Frikke-Schmidt R, Tybjærg-Hansen A. Low PCSK9 and LDL cholesterol and risk of dementia, parkinson’s disease, and epilepsy-a mendelian randomization study. Circulation 2015;132. ID - ref74 ER - TY - JOUR AU - Brunkhorst, R. AU - Vutukuri, R. AU - Pfeilschifter, W. PY - 2014 DA - 2014// TI - Fingolimod for the treatment of neurological diseases-state of play and future perspectives JO - Front Cell Neurosci VL - 8 UR - https://doi.org/10.3389/fncel.2014.00283 DO - 10.3389/fncel.2014.00283 ID - Brunkhorst2014 ER - TY - STD TI - Hirabayashi Y, Furuya S. Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival. Prog Lipid Res. 2008:188–203. ID - ref76 ER - TY - STD TI - Bartke N, Hannun Y a. Bioactive sphingolipids: metabolism and function. J Lipid Res. 2009;50:S91–6. Available from: http://www.jlr.org/lookup/doi/10.1194/jlr.R800080-JLR200. UR - http://www.jlr.org/lookup/doi/10.1194/jlr.R800080-JLR200 ID - ref77 ER - TY - JOUR AU - Tidhar, R. AU - Futerman, A. H. PY - 2013 DA - 2013// TI - The complexity of sphingolipid biosynthesis in the endoplasmic reticulum JO - Biochim Biophys Acta - Mol Cell Res VL - 1833 UR - https://doi.org/10.1016/j.bbamcr.2013.04.010 DO - 10.1016/j.bbamcr.2013.04.010 ID - Tidhar2013 ER - TY - STD TI - Olsen ASB, Færgeman NJ. Sphingolipids: Membrane microdomains in brain development, function and neurological diseases. Open Biol. 2017;7(5):170069. ID - ref79 ER - TY - STD TI - Castillo RI, Rojo LE, Henriquez-Henriquez M, Silva H, Maturana A, Villar MJ, et al. From molecules to the clinic: linking schizophrenia and metabolic syndrome through sphingolipids metabolism. Front Neurosci. 2016:488. ID - ref80 ER - TY - STD TI - Sonnino S, Prinetti A. The role of sphingolipids in neuronal plasticity of the brain. J Neurochem. 2016:485–8. ID - ref81 ER - TY - STD TI - Dotti CG, Esteban JA, Ledesma MD. Lipid dynamics at dendritic spines. Front Neuroanat. 2014;8. Available from: http://journal.frontiersin.org/article/10.3389/fnana.2014.00076/abstract. UR - http://journal.frontiersin.org/article/10.3389/fnana.2014.00076/abstract ID - ref82 ER - TY - JOUR AU - Wheeler, D. AU - Knapp, E. AU - Bandaru, V. V. R. AU - Wang, Y. AU - Knorr, D. AU - Poirier, C. PY - 2009 DA - 2009// TI - Tumor necrosis factor-α-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors JO - J Neurochem VL - 109 UR - https://doi.org/10.1111/j.1471-4159.2009.06038.x DO - 10.1111/j.1471-4159.2009.06038.x ID - Wheeler2009 ER - TY - JOUR AU - Tabatadze, N. AU - Savonenko, A. AU - Song, H. AU - Bandaru, V. V. R. AU - Chu, M. AU - Haughey, N. J. PY - 2010 DA - 2010// TI - Inhibition of neutral sphingomyelinase-2 perturbs brain sphingolipid balance and spatial memory in mice JO - J Neurosci Res VL - 88 ID - Tabatadze2010 ER - TY - JOUR AU - Darios, F. AU - Wasser, C. AU - Shakirzyanova, A. AU - Giniatullin, A. AU - Goodman, K. AU - Munoz-Bravo, J. L. PY - 2009 DA - 2009// TI - Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis JO - Neuron VL - 62 UR - https://doi.org/10.1016/j.neuron.2009.04.024 DO - 10.1016/j.neuron.2009.04.024 ID - Darios2009 ER - TY - JOUR AU - Kanno, T. AU - Nishizaki, T. AU - Proia, R. L. AU - Kajimoto, T. AU - Jahangeer, S. AU - Okada, T. PY - 2010 DA - 2010// TI - Regulation of synaptic strength by sphingosine 1-phosphate in the hippocampus JO - Neuroscience VL - 171 UR - https://doi.org/10.1016/j.neuroscience.2010.10.021 DO - 10.1016/j.neuroscience.2010.10.021 ID - Kanno2010 ER - TY - STD TI - Riganti L, Antonucci F, Gabrielli M, Prada I, Giussani P, Viani P, et al. Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. J Neurosci. 2016;36:4624–34. Available from: http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3588-15.2016. UR - http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.3588-15.2016 ID - ref87 ER - TY - CHAP AU - Hsieh, J. AU - Song, H. ED - Sweatt, J. D. ED - Meaney, M. J. ED - Nestler, E. J. ED - Akbarian, S. PY - 2013 DA - 2013// TI - Chapter 12 - Adult Neurogenesis BT - Epigenetic Regul Nerv Syst PB - Academic Press CY - San Diego UR - https://doi.org/10.1016/B978-0-12-391494-1.00012-4 DO - 10.1016/B978-0-12-391494-1.00012-4 ID - Hsieh2013 ER - TY - JOUR AU - Schwarz, A. AU - Rapaport, E. AU - Hirschberg, K. PY - 1995 DA - 1995// TI - Futerman AH. A regulatory role for sphingolipids in neuronal growth: inhibition of sphingolipid synthesis and degradation have opposite effects on axonal branching JO - J Biol Chem VL - 270 UR - https://doi.org/10.1074/jbc.270.18.10990 DO - 10.1074/jbc.270.18.10990 ID - Schwarz1995 ER - TY - JOUR AU - Hussain, G. AU - Zhang, L. AU - Rasul, A. AU - Anwar, H. AU - Sohail, M. AU - Razzaq, A. PY - 2018 DA - 2018// TI - Role of plant-derived flavonoids and their mechanism in attenuation of Alzheimer’s and Parkinson’s diseases: an update of recent data JO - Molecules VL - 23 UR - https://doi.org/10.3390/molecules23040814 DO - 10.3390/molecules23040814 ID - Hussain2018 ER - TY - STD TI - Abeliovich A, Gitler AD. Defects in trafficking bridge Parkinson’s disease pathology and genetics. Nature. 2016:207–16. ID - ref91 ER - TY - STD TI - Suzuki M, Sango K, Wada K, Nagai Y. Pathological role of lipid interaction with α-synuclein in Parkinson’s disease. Neurochem Int. 2018;119:97–106. ID - ref92 ER - TY - STD TI - Gegg ME, Schapira AHV. The role of glucocerebrosidase in Parkinson disease pathogenesis. FEBS J. 2018:3591–603. ID - ref93 ER - TY - JOUR AU - Kim, M. J. AU - Jeon, S. AU - Burbulla, L. F. AU - Krainc, D. PY - 2018 DA - 2018// TI - Acid ceramidase inhibition ameliorates α-synuclein accumulation upon loss of GBA1 function JO - Hum Mol Genet VL - 27 UR - https://doi.org/10.1093/hmg/ddy105 DO - 10.1093/hmg/ddy105 ID - Kim2018 ER - TY - STD TI - Rocha EM, De Miranda B, Sanders LH. Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson’s disease. Neurobiol Dis. 2018;109:249–57. ID - ref95 ER - TY - STD TI - Dinkins MB, Enasko J, Hernandez C, Wang G, Kong J, Helwa I, et al. Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer’s Disease Pathology and Improves Cognition in the 5XFAD Mouse. J Neurosci. 2016;36:8653–67. Available from: http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1429-16.2016. UR - http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.1429-16.2016 ID - ref96 ER - TY - STD TI - Dinkins MB, Wang G, Bieberich E. Sphingolipid-enriched extracellular vesicles and Alzheimer’s disease: a decade of research. J Alzheimers Dis. 2017:757–68. ID - ref97 ER - TY - JOUR AU - Lu, M. H. AU - Ji, W. L. AU - Xu, D. E. AU - Yao, P. P. AU - Zhao, X. Y. AU - Wang, Z. T. PY - 2019 DA - 2019// TI - Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1 JO - Exp Neurol VL - 311 UR - https://doi.org/10.1016/j.expneurol.2018.09.012 DO - 10.1016/j.expneurol.2018.09.012 ID - Lu2019 ER - TY - STD TI - Herzer S, Hagan C, von Gerichten J, Dieterle V, Munteanu B, Sandhoff R, et al. Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer’s Disease. Front Mol Neurosci. 2018;11:1–17. Available from: https://www.frontiersin.org/article/10.3389/fnmol.2018.00206/full. UR - https://www.frontiersin.org/article/10.3389/fnmol.2018.00206/full ID - ref99 ER - TY - STD TI - Jęśko H, Wencel PL, Lukiw WJ, Strosznajder RP. Modulatory effects of Fingolimod (FTY720) on the expression of sphingolipid metabolism-related genes in an animal model of Alzheimer’s disease. Mol Neurobiol. 2018:1–12. ID - ref100 ER - TY - JOUR AU - Malm, T. AU - Loppi, S. AU - Kanninen, K. M. PY - 2016 DA - 2016// TI - Exosomes in Alzheimer’s disease JO - Neurochem Int VL - 97 UR - https://doi.org/10.1016/j.neuint.2016.04.011 DO - 10.1016/j.neuint.2016.04.011 ID - Malm2016 ER - TY - STD TI - Dansokho C, Heneka MT. Neuroinflammatory responses in Alzheimer’s disease. J Neural Transm. 2018;125(5):771–9. ID - ref102 ER - TY - JOUR AU - Ginkel, C. AU - Hartmann, D. AU - Vom Dorp, K. AU - Zlomuzica, A. AU - Farwanah, H. AU - Eckhardt, M. PY - 2012 DA - 2012// TI - Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M112.413500 DO - 10.1074/jbc.M112.413500 ID - Ginkel2012 ER - TY - JOUR AU - Sugiyama, A. AU - Sawai, S. AU - Ito, S. AU - Mukai, H. AU - Beppu, M. AU - Yoshida, T. PY - 2015 DA - 2015// TI - Incidental diagnosis of an asymptomatic adult-onset Alexander disease by brain magnetic resonance imaging for preoperative evaluation JO - J Neurol Sci Elsevier BV VL - 354 UR - https://doi.org/10.1016/j.jns.2015.05.001 DO - 10.1016/j.jns.2015.05.001 ID - Sugiyama2015 ER - TY - STD TI - Godeiro Junior CD, Vale TC, Afonso CO, Kok F, Pedroso JL, Barsottini OG. Progressive Myoclonic Epilepsy Type 8 Due to CERS1 Deficiency: A Novel Mutation with Prominent Ataxia. Mov Disord Clin Pract. 2018;5:330–2. Available from: http://doi.wiley.com/10.1002/mdc3.12610. UR - http://doi.wiley.com/10.1002/mdc3.12610 ID - ref105 ER - TY - STD TI - Scicchitano P, Cameli M, Maiello M, Modesti PA, Muiesan ML, Novo S, et al. Nutraceuticals and dyslipidaemia: beyond the common therapeutics. J Funct Foods. 2014;6:11–32. ID - ref106 ER - TY - STD TI - Silva Afonso M, Marcondes Machado R, Ferrari Lavrador MS, Rocha Quintao EC, Moore KJ, Lottenberg AM. Molecular pathways underlying cholesterol homeostasis. Nutrients. 201813;10(6):1–18. ID - ref107 ER - TY - JOUR AU - Volpe, R. AU - Sotis, G. PY - 2015 DA - 2015// TI - Nutraceuticals: definition and epidemiological rationale for their use in clinical practice JO - High Blood Press Cardiovasc Prev VL - 22 UR - https://doi.org/10.1007/s40292-015-0092-5 DO - 10.1007/s40292-015-0092-5 ID - Volpe2015 ER - TY - STD TI - Santini A, Novellino E. Nutraceuticals in hypercholesterolaemia: an overview. Br J Pharmacol. 2017;174(11):1450–63. ID - ref109 ER - TY - STD TI - Norris GH, Blesso CN. Dietary and endogenous sphingolipid metabolism in chronic inflammation. Nutrients. 2017;9(11):1180. ID - ref110 ER - TY - STD TI - Potočki S. Potential health benefits of sphingolipids in milk and dairy products. Mljekarstvo. 2016;66:251–61. Available from: https://doi.org/10.15567/mljekarstvo.2016.0401. ID - ref111 ER -