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Fig. 1 | Lipids in Health and Disease

Fig. 1

From: Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population

Fig. 1

The activation of 5-lipoxygenase (5-LO) pathway of AA metabolism by the enzymes 5-lipoxygenase activating protein (FLAP) and 5-lipoxygenase (5-LO) will catalyze the conversion of AA into the chemokine, leukotriene A4 (LTA4), which will be converted into other leukotrienes by the enzymes LTA4 hydrolase (LTA4H) and LTC4 synthase (LTC4S). These leukotrienes act on leukotriene receptors in lymphocytes, endothelial, and smooth muscle cells, which further enhance inflammatory reactions and subsequently, atherogenesis

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Lipids in Health and Disease

ISSN: 1476-511X