Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population

Table 1 Baseline characteristics of the study participants

Variables	MI (n = 401)	Controls (n = 409)	P-value^a
Age, years	58.20 (11.65)	56.34 (9.52)	0.223
Male sex, No. (%)	329 (82.0%)	339 (82.9%)	0.753
Smoking, No. (%)	242 (60.3%)	187 (45.7%)	3.04E-05
Alcohol, No. (%)	105 (26.2%)	82 (20.0%)	0.038
Diabetes, No. (%)	99 (26.7%)	50 (12.2%)	4.71E-06
Hypertension, No. (%)	192 (47.9%)	143 (35.0%)	1.90E-4
Hypercholesterolemia, No. (%)	55 (13.7%)	39 (9.5%)	0.063
WBC, 10⁹/L	11.96 (3.81)	6.84 (1.90)	1.78E-80
FBG, mmol/L	7.13 (3.86)	5.93 (1.93)	1.25E-7
CRE, μmol/L	85.67 (30.17)	70.83 (13.30)	3.22E-18
AST, U/L	80.44 (85.24)	25.12 (9.43)	2.54E-32
Total cholesterol, mmol/L	4.56 (1.05)	4.96 (0.84)	7.03E-9
Triglycerides, mmol/L	1.65 (1.12)	1.67 (1.23)	0.764
HDL cholesterol, mmol/L	1.28 (0.43)	1.37 (0.36)	1.65E-3
LDL cholesterol, mmol/L	2.77 (0.83)	3.30 (0.73)	1.92E-20

Values are means ± SD or n (%). ^aTwo-sided chi-square test or independent-samples t-test. ^bP-values < 0.05 are bold. Type 2 diabetes was diagnosed as (1) fasting plasma glucose (FPG) ≥ 7.0 mmol/L; (2) 2 h postprandial glucose ≥11.1 mmol/L; or (3) use of antidiabetes medications. Hypertension was defined as systolic/diastolic blood pressure ≥ 140 mmHg or ≥ 90 mmHg or use of antihypertensive medications. Hypercholesterolemia was defined as use of cholesterol-lowering medications or total serum cholesterol > 200 mg/dl. WBC, white blood cell; FBG, fasting blood glucose; AST, aspartate transaminase; CRE, creatinine; HDL, high-density lipoprotein; LDL, low-density lipoprotein

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