Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population

Table 3 Genetic model analysis of the association of six SNPs and MI susceptibility

SNP/group	Genotype		χ²	P	OR (95% CI)
rs12762303
Dominant	CC+ CT	TT	0.10	0.92	0.98 (0.73–1.32)
Recessive	CC	CT + TT	0.16	0.69	1.14 (0.59–2.18)
Codominant	TT	CT	0.06	0.81	0.96 (0.71–1.31)
		CC	0.12	0.72	1.12 (0.58–2.17)
Overdominant	TT + CC	CT	0.08	0.76	1.04 (0.77–1.42)
rs12264801
Dominant	AA+GA	GG	0.03	0.85	0.97 (0.72–1.31)
Recessive	AA	GA + GG	0.87	0.35	0.85 (0.61–1.19)
Codominant	GG	GA	0.02	0.88	1.02 (0.74–1.42)
		AA	0.51	0.48	0.87 (0.59–1.28)
Overdominant	GG + AA	GA	0.39	0.53	0.91 (0.70–1.21)
rs10507391
Dominant	AA +TA	TT	0.17	0.68	1.06 (0.80–1.41)
Recessive	AA	TA + TT	0.12	0.91	0.98 (0.64–1.49)
Codominant	TT	TA	0.22	0.63	1.07 (0.80–1.44)
		AA	0.00	0.95	1.01 (0.64–1.59)
Overdominant	TT + AA	TA	0.23	0.63	0.93 (0.71–1.23)
rs2072512
Dominant	AA +TA	TT	0.42	0.51	1.10 (0.83–1.46)
Recessive	AA	TA + TT	0.47	0.49	0.79 (1.13)
Codominant	TT	TA	0.18	0.66	1.06 (0.79–1.45)
		AA	0.64	0.42	1.18 (0.79–1.75)
Overdominant	TT + AA	TA	0.01	0.91	0.98 (0.75–1.30)
rs2540487
Dominant	TT + CT	CC	4.36	0.037	0.73 (0.55–0.98)
Recessive	TT	CT + CC	0.99	0.32	1.36 (0.74–2.51)
Codominant	CC	CT	6.29	0.012	0.68 (0.51–0.92)
		TT	0.31	0.57	1.19 (0.64–2.22)
Overdominant	CC + TT	CT	6.97	0.008 ^a	1.48 (1.11–1.99)
rs2540477
Dominant	GG + AG	AA	0.90	0.34	0.84 (0.59–1.20)
Recessive	GG	AG + AA	0.16	0.69	0.94 (0.70–1.26)
Codominant	AA	AG	0.74	0.38	0.85 (0.58–1.23)
		GG	0.78	0.38	0.83 (0.56–1.25)
Overdominant	AA+GG	AG	0.13	0.72	1.05 (0.80–1.39)

SNP, single nucleotide polymorphism; MI, myocardial infarction. A P < 0.01 was considered statistically significant after Bonferroni correction. ^a P-values < 0.01 are bold

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