Changes in lipids composition and metabolism in colorectal cancer: a review

Pakiet, Alicja; Kobiela, Jarosław; Stepnowski, Piotr; Sledzinski, Tomasz; Mika, Adriana

doi:10.1186/s12944-019-0977-8

Lipids in Health and Disease

Table 1 Colorectal cancer related changes of lipid species content in various biological samples

From: Changes in lipids composition and metabolism in colorectal cancer: a review

Research material	Lipid species	Lipid fraction	Direction of change	Reference
Cancer tissue	14:0	total lipids	↓	Mika et al. (2017) [22]
		total lipids	↑	Qiu et al. (2014) [179]
	16:0	total lipids	↓	Mika et al. (2017) [22]
			↓	Li et al. (2013) [178]
		ceramides	↑	Chen et al. (2015) [183]
			↑	Chen et al. (2016) [184]
		lysophosphatidylcholines	↑	Mirnezami et al. (2014) [177]
			↑	Li et al. (2013) [178]
		lysophosphatidic acid	↑	Li et al. (2013) [178]
	18:0	total lipids	↑	Mika et al. (2017) [22]
			↑	Zhang et al. (2013) [86]
		free fatty acids	↑	Chen et al. (2015) [183]
		total lipids	↓	Li et al. (2013) [178]
		ceramides	↓	Chen et al. (2015) [183]
			↓	Chen et al. (2016) [184]
		lysophosphatidylcholines	↑	Li et al. (2013) [178]
		lysophosphatidic acid	↑	Li et al. (2013) [178]
	20:0	total lipids	↑	Mika et al. (2017) [22]
		ceramides	↓	Chen et al. (2015) [183]
			↓	Chen et al. (2016) [184]
	22:0	total lipids	↑	Mika et al. (2017) [22]
		sphingomyelin	↓	Guo et al. (2014) [175]
	24:0	total lipids	↑	Mika et al. (2017) [22]
		free fatty acids	↑	Chen et al. (2015) [183]
		ceramides	↑	Chen et al. (2015) [183]
			↑	Chen et al. (2016) [184]
	26:0	total lipids	↑	Mika et al. (2017) [22]
	14:1	total lipids	↓	Mika et al. (2017) [22]
		free fatty acids	↑	Chen et al. (2015) [183]
	16:1 n-7	total lipids	↓	Mika et al. (2017) [22]
			↓	Zhang et al. (2013) [86]
		total lipids	↑	Qiu et al. (2014) [179]
	16:1 n-7	free fatty acids	↑	Chen et al. (2015) [183]
			↑	Guo et al. (2014) [175]
	18:1 n-9	total lipids	↓	Mika et al. (2017) [22]
			↓	Zhang et al. (2013) [86]
	18:1 n-9	free fatty acids	↑	Guo et al. (2014) [175]
			↑	Chen et al. (2015) [183]
	18:1 n-9	lysophosphatidylcholines	↑	Mirnezami et al. (2014) [177]
			↑	Li et al. (2013) [178]
	20:1	free fatty acids	↑	Guo et al. (2014) [175]
			↑	Chen et al. (2015) [183]
	22:1	total lipids	↑	Mika et al. (2017) [22]
	22:1	free fatty acids	↑	Chen et al. (2015) [183]
	24:1	total lipids	↑	Mika et al. (2017) [22]
	24:1	free fatty acids	↑	Chen et al. (2015) [183]
	24:1	ceramides	↑	Chen et al. (2015) [183]
			↑	Chen et al. (2016) [184]
	24:1	sphingomyelin	↓	Guo et al. (2014) [175]
	26:1	total lipids	↑	Mika et al. (2017) [22]
	18:2 n-6	total lipids	↑	Zhang et al. (2013) [86]
	18:2 n-6	total lipids	↓	Yang et al. (2015) [130]
	20:2 n-6	total lipids	↑	Zhang et al. (2013) [86]
	20:2 n-6	free fatty acids	↑	Chen et al. (2015) [183]
	20:4 n-6	total lipids	↑	Mika et al. (2017) [22]
			↑	Zhang et al. (2013) [86]
	20:4 n-6	free fatty acids	↓	Guo et al. (2014) [175]
	20:4 n-6	lysophosphatidylcholines	↓	Li et al. (2013) [178]
	20:3 n-6	total lipids	↑	Zhang et al. (2013) [86]
			↑	Yang et al. (2015) [130]
	22:4 n-6	free fatty acids	↓	Guo et al. (2014) [175]
	22:4 n-6	free fatty acids	↑	Chen et al. (2015) [183]
	20:5 n-3	total lipids	↑	Mika et al. (2017) [22]
			↑	Yang et al. (2015) [130]
	20:5 n-3	free fatty acids	↑	Chen et al. (2015) [183]
	20:5 n-3	total lipids	↓	Zhang et al. (2013) [86]
	20:5 n-3	free fatty acids	↓	Guo et al. (2014) [175]
	22:6 n-3	total lipids	↑	Mika et al. (2017) [22]
			↑	Yang et al. (2015) [130]
	22:6 n-3	free fatty acids	↑	Chen et al. (2015) [183]
	22:6 n-3	total lipids	↓	Zhang et al. (2013) [86]
	22:6 n-3	lysophosphatidylcholines	↓	Li et al. (2013) [178]
	malondialdehyde		↑	Skrzydlewska et al. (2005) [154]
	4-hydroxynonenal		↑	Skrzydlewska et al. (2005) [154]
	1,2-DG-36:3		↓	Alexander et al. (2017) [206]
	Cer-d18:0/H24:0		↑	Alexander et al. (2017) [206]
	Cer-t18:0/24:0(2OH)		↑	Alexander et al. (2017) [206]
	GlcCer-30:1		↑	Alexander et al. (2017) [206]
	PA-31:0		↑	Alexander et al. (2017) [206]
	PA-34:0		↑	Alexander et al. (2017) [206]
	PA-36:2		↑	Guo et al. (2014) [175]
	PA-38:3		↓	Guo et al. (2014) [175]
	PA-40:5		↓	Guo et al. (2014) [175]
	PC-16:0/16:1		↑	Kurabe et al. (2013) [176]
	PC-16:0/18:1		↑	Mirnezami et al. (2014) [177]
	PC-32:1		↑	Shen et al. (2017) [89]
	PC-34:1		↑	Guo et al. (2014) [175]
			↑	Li et al. (2013) [178]
	PC-36:1		↑	Guo et al. (2014) [175]
	PC-38:4		↓	Guo et al. (2014) [175]
	PC-38:6		↓	Guo et al. (2014) [175]
	PE-34:4		↑	Alexander et al. (2017) [206]
	PE-38:4		↓	Guo et al. (2014) [175]
	PG 38:4		↓	Alexander et al. (2017) [206]
	PG-36:1		↑	Alexander et al. (2017) [206]
	PI-38:4		↓	Guo et al. (2014) [175]
	PS-41:0		↑	Alexander et al. (2017) [206]
	PS-43:4		↓	Alexander et al. (2017) [206]
	PS-44:6		↑	Alexander et al. (2017) [206]
	PS-44:8		↑	Alexander et al. (2017) [206]
	SM-22:0		↓	Guo et al. (2014) [175]
	SM-24:1		↓	Guo et al. (2014) [175]
	TG-54:0		↓	Alexander et al. (2017) [206]
serum	14:0	total lipids	↓	Kondo et al.. (2011) [85]
		total lipids	↑	Mika et al.. (2017) [22]
	15:0	total lipids	↓	Kondo et al.. (2011) [85]
	18:0	total lipids	↓	Mika et al. (2017) [22]
			↓	Kondo et al. (2011) [85]
	22:0	total lipids	↑	Mika et al. (2017) [22]
	24:0	total lipids	↑	Kondo et al. (2011) [85]
	26:0	total lipids	↑	Mika et al. (2017) [22]
			↑	Kondo et al. (2011) [85]
	28:0	total lipids	↑	Kondo et al. (2011) [85]
	30:0	total lipids	↑	Kondo et al. (2011) [85]
	18:1 n-9	total lipids	↑	Mika et al. (2017) [22]
	26:1	total lipids	↑	Mika et al. (2017) [22]
	18:2 n-6	total lipids	↓	Zhu et al. (2014) [134]
	18:3 n-6	total lipids	↓	Kondo et al. (2011) [85]
	18:3 n-3	total lipids	↓	Mika et al. (2017) [22]
			↓	Zhu et al. (2014) [134]
	20:5 n-3	total lipids	↓	Mika et al. (2017) [22]
	9,10-DiHOME		↓	Zhang et al. (2017) [153]
	12,13-DiHOME		↓	Zhang et al. (2017) [153]
	9-HpODE		↓	Zhang et al. (2017) [153]
	9-HODE		↓	Zhang et al. (2017) [153]
	9-KODE		↓	Zhang et al. (2017) [153]
	13-HpODE		↓	Zhang et al. (2017) [153]
	13-HODE		↓	Zhang et al. (2017) [153]
	13-KODE		↓	Zhang et al. (2017) [153]
	19-HETE		↓	Zhang et al. (2017) [153]
	20-HETE		↓	Zhang et al. (2017) [153]
	12-keto-LTB4		↓	Zhang et al. (2017) [153]
	PGE2		↓	Zhang et al. (2017) [153]
	2-hydroxy-PGE2		↓	Zhang et al. (2017) [153]
	5-HpETE		↓	Zhang et al. (2017) [153]
	5-HETE		↓	Zhang et al. (2017) [153]
	LTD4		↑	Zhang et al. (2017) [153]
	LTE4		↑	Zhang et al. (2017) [153]
	14,15-LTE4		↑	Zhang et al. (2017) [153]
	12-keto-LTB4		↓	Zhang et al. (2017) [153]
	5S,6R-LXA4		↓	Zhang et al. (2017) [153]
	12-HETE		↓	Zhang et al. (2017) [153]
	15-HETE		↓	Zhang et al. (2017) [153]
			↓	Chen et al. (2003) [166]
	8-HETE		↓	Zhang et al. (2017) [153]
	14,15-DHET		↓	Zhang et al. (2017) [153]
	8,9-DHET		↓	Zhang et al. (2017) [153]
	5,6-DHET		↓	Zhang et al. (2017) [153]
	14,15-EET		↓	Zhang et al. (2017) [153]
	8-iso-PGF2α		↓	Zhang et al. (2017) [153]
	8-iso-PGE2		↓	Zhang et al. (2017) [153]
	2,3-dinor-8-iso-PGF2α		↑	Zhang et al. (2017) [153]
	GTA-446		↓	Ritchie et al. (2010) [168]
			↓	Hata et al. (2017) [170]
plasma	16:0	total lipids	↑	Okuno et al. (2013) [172]
		total lipids	↓	Butler et al. (2017) [87]
	18:0	total lipids	↓	Butler et al. (2017) [87]
	24:0	total lipids	↓	Okuno et al. (2013) [172]
	16:1 n-7	total lipids	↓	Butler et al. (2017) [87]
	18:1 n-9	total lipids	↓	Butler et al. (2017) [87]
	20:1	total lipids	↓	Okuno et al. (2013) [172]
	20:1	free fatty acids	↑	Shen et al. (2017) [89]
	18:2 n-6	total lipids	↓	Butler et al. (2017) [87]
	18:3 n-6	total lipids	↓	Butler et al. (2017) [87]
	20:2 n-6	free fatty acids	↑	Shen et al. (2017) [89]
	20:3 n-6	total lipids	↓	Butler et al. (2017) [87]
	20:5 n-3	total lipids	↓	Okuno et al. (2013) [172]
	22:4 n-6	free fatty acids	↑	Shen et al. (2017) [89]
	18:3 n-3	total lipids	↓	Butler et al. (2017) [87]
	Cer-d18:1/26:4		↑	Shen et al. (2017) [89]
	LPC-18:2		↓	Shen et al. (2017) [89]
	LPC-18:3		↓	Shen et al. (2017) [89]
			↓	Li et al. (2013) [178]
	PE-18:1/20:2		↓	Shen et al. (2017) [89]
	PE-18:2/18:1		↓	Shen et al. (2017) [89]
	PG-18:0/16:0		↑	Shen et al. (2017) [89]
	SM-38:8		↓	Shen et al. (2017) [89]
	SM-d18:1/24:1		↑	Shen et al. (2017) [89]
erythrocyte	18:0	total lipids	↑	Neoptolemos et al. (1988) [218]
	20:0	total lipids	↓	Okuno et al. (2013) [172]
	18:1 n-9	total lipids	↑	Neoptolemos et al. (1988) [218]
	24:1	total lipids	↑	Okuno et al. (2013) [172]
	20:4 n-6	total lipids	↓	Neoptolemos et al. (1988) [218]
	20:5 n-3	total lipids	↓	Okuno et al. (2013) [172]
adipose tissue	16:1 n-9	total lipids	↑	Cottet et al. (2015) [217]
	20:1	total lipids	↑	Neoptolemos et al. (1988) [218]
	18:3 n-6	total lipids	↑	Giuliani et al. (2014) [92]
	20:3 n-6	total lipids	↑	Giuliani et al. (2014) [92]
			↑	Cottet et al. (2015) [217]
	22:4 n-6	total lipids	↑	Giuliani et al. (2014) [92]
			↑	Okuno et al. (2013) [172]
	18:3 n-3	total lipids	↓	Giuliani et al. (2014) [92]
			↓	Cottet et al. (2015) [217]
	18:4 n-3	total lipids	↓	Giuliani et al. (2014) [92]
	22:5 n-3	total lipids	↑	Cottet et al. (2015) [217]

Cer ceramide, DG diacylglycerol, DHET dihydroxyeicosatrienoic acid, DiHOME dihydroxyoctadecenoic acid, EET epoxyeicosatrienoic acid, GlcCer glucosylceramide, HETE hydroxyeicosatetraenoic acid, HODE hydroxyoctadecadienoic acid, HpETE hydroperoxyeicosatetraenoic acid, HpODE hydroperoxyoctadecadienoic acid, KODE ketooctadecadienoic acid, LPC lysophosphatidylcholine, LT leukotriene, LX lipoxin, PA phosphatidic acid, PC phosphatidylcholine, PE phosphorylethanolamine, PG phosphatidylglycerol, PGE/F prostaglandin E/F, PI phosphatidylinositol, PS phosphatidylserine, SM sphingomyelin, TG triacylglycerol

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