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Table 4 Association between I148M and E167K variants and clinical features in the whole subjects

From: Combining I148M and E167K variants to improve risk prediction for nonalcoholic fatty liver disease in Qingdao Han population, China

 

PNPLA3 I148M

TM6SF2 E167K

Noncarriers

Carriers

t

P value

Noncarriers

Carriers

t

P value

N

310

653

  

841

122

  

BMI(kg/m^2)

24.17 ± 3.41

25.00 ± 3.70

−3.323

0.000

24.73 ± 3.64

24.75 ± 3.55

−0.053

0.958

ALB(g/L)

46.59 ± 2.22

46.47 ± 2.78

0.629

0.529

46.47 ± 2.38

46.82 ± 3.86

−0.997

0.321

FPG (mmol/L)

4.75 ± 1.21

4.90 ± 2.34

−1.064

0.288

4.87 ± 2.16

4.75 ± 1.02

−0.556

0.578

ALT (U/L)

23.68 ± 18.04

31.64 ± 23.02

−5.837

0.000

28.91 ± 22.31

30.25 ± 18.44

−0.634

0.527

AST (U/L)

21.86 ± 7.06

24.82 ± 11.81

−4.851

0.000

23.73 ± 10.57

24.83 ± 10.77

−1.070

0.285

GGT (U/L)

30.83 ± 25.99

38.77 ± 34.60

−3.960

0.000

36.68 ± 33.02

32.98 ± 26.55

1.185

0.236

ALP (U/L)

64.86 ± 15.67

72.53 ± 25.52

−5.731

0.000

69.72 ± 22.87

72.40 ± 24.54

−1.195

0.232

TG (mmol/L)

1.27 ± 0.81

1.92 ± 1.66

−8.124

0.000

1.75 ± 1.52

1.43 ± 0.99

3.057

0.003

TC (mmol/L)

5.25 ± 0.99

5.39 ± 1.04

−2.000

0.046

5.38 ± 1.05

5.15 ± 0.80

2.788

0.006

HDL (mmol/L)

1.33 ± 0.25

1.33 ± 0.28

0.042

0.967

1.32 ± 0.27

1.38 ± 0.33

−1.863

0.065

LDL (mmol/L)

3.03 ± 0.76

3.48 ± 1.20

−6.723

0.000

3.35 ± 1.12

3.23 ± 0.91

1.125

0.261

UA (mmol/L)

342.72 ± 94.88

365.84 ± 92.41

−3.581

0.000

359.04 ± 95.72

354.13 ± 79.58

0.619

0.536

  1. Abbreviations: BMI body mass index, ALB albumin, FPG fasting plasma glucose, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT γ-glutamyltransferase, ALP alkaline phosphatase, TG triglyceride, TC total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein, UA uric acid