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Table 2 Association of ABCA1 polymorphism and the risk of diabetes mellitus with a dominant model

From: ATP-binding cassette sub-family a member1 gene mutation improves lipid metabolic abnormalities in diabetes mellitus

Category N Subjects, cases/controls Heterogeneity OR (95% CI) Z test
Ph I2 (%)
Three studies for the ABCA1-C69T polymorphism    
Overall 3 647/595 < 0.00 94 0.66 (0.24–1.83) Z = 0.80; PZ = 0.42
Adjustment by the lipid composition
 CHO 3 317/383 0.002 84 0.40 (−0.18–0.99) Z = 1.36; PZ = 0.17
 TG 3 317/383 0.08 60 0.54 (0.28–0.80) Z = 4.00; PZ < 0.0001
 LDL 3 317/383 0.006 80 0.06(−0.37–0.48) Z = 0.27; PZ = 0.79
 HDL 3 317/383 0.004 82 0.09(−0.07–0.25) Z = 1.09; PZ = 0.27
Adjustment by blood pressure
 SBP 2 141/109 0.13 57 6.60 (−1.64–14.85) Z = 1.57; PZ = 0.12
 DSP 2 141/109 < 0.00 94 1.36(−1.33–4.05) Z = 0.99; PZ = 0.32
Three studies for the ABCA1-R230C polymorphism
 C allele 3 2198/1394 0.18 42 1.34 (1.02–1.76)† Z = 2.11; PZ = 0.04
 T allele 3 2198/1394 0.18 42 0.75(0.57–0.98)† Z = 2.11; PZ = 0.04
  1. CHO Cholesterol, TG Triglyceride, HDL High density lipoprotein, LDL Low density lipoprotein, SBP systolic blood pressure, DBP diastolic blood pressure, N number of invealed studies, Ph P values for heterogeneity of Q test; † Fixed-effects model. PZ < 0.05, indicate significant association