ATP-binding cassette sub-family a member1 gene mutation improves lipid metabolic abnormalities in diabetes mellitus

Table 2 Association of ABCA1 polymorphism and the risk of diabetes mellitus with a dominant model

Category	N	Subjects, cases/controls	Heterogeneity	OR (95% CI)	Z test
Category	N	Subjects, cases/controls	P_h I² (%)	OR (95% CI)	Z test
Three studies for the ABCA1-C69T polymorphism
Overall	3	647/595	< 0.00 94	0.66 (0.24–1.83)	Z = 0.80; P_Z = 0.42
Adjustment by the lipid composition
CHO	3	317/383	0.002 84	0.40 (−0.18–0.99)	Z = 1.36; P_Z = 0.17
TG	3	317/383	0.08 60	0.54 (0.28–0.80)	Z = 4.00; P_Z < 0.0001
LDL	3	317/383	0.006 80	0.06(−0.37–0.48)	Z = 0.27; P_Z = 0.79
HDL	3	317/383	0.004 82	0.09(−0.07–0.25)	Z = 1.09; P_Z = 0.27
Adjustment by blood pressure
SBP	2	141/109	0.13 57	6.60 (−1.64–14.85)	Z = 1.57; P_Z = 0.12
DSP	2	141/109	< 0.00 94	1.36(−1.33–4.05)	Z = 0.99; P_Z = 0.32
Three studies for the ABCA1-R230C polymorphism
C allele	3	2198/1394	0.18 42	1.34 (1.02–1.76)†	Z = 2.11; P_Z = 0.04
T allele	3	2198/1394	0.18 42	0.75(0.57–0.98)†	Z = 2.11; P_Z = 0.04

CHO Cholesterol, TG Triglyceride, HDL High density lipoprotein, LDL Low density lipoprotein, SBP systolic blood pressure, DBP diastolic blood pressure, N number of invealed studies, Ph P values for heterogeneity of Q test; † Fixed-effects model. P_Z < 0.05, indicate significant association

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