TRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of non-alcoholic fatty liver disease in Chinese Han population

Liu, Qun; Xue, Feng; Meng, Jing; Liu, Shou-Sheng; Chen, Li-Zhen; Gao, Hui; Geng, Ning; Jin, Wen-Wen; Xin, Yong-Ning; Xuan, Shi-Ying

doi:10.1186/s12944-019-1001-z

Lipids in Health and Disease

Table 6 Clinical Characteristics of TRIB1 rs2954029 A Carriers and Non-Carriers in the Study Population^a

From: TRIB1 rs17321515 and rs2954029 gene polymorphisms increase the risk of non-alcoholic fatty liver disease in Chinese Han population

Characteristic	Overall Series			NAFLD Patients			Controls
Characteristic	Carriers (n = 212)	Non-Carriers (n = 109)	P Value	Carriers (n = 106)	Non-Carriers (n = 40)	P Value	Carriers (n = 106)	Non-Carriers (n = 69)	P Value
Female, %	97 (45.8)	55 (50.5)	0.424	44 (41.5)	21 (52.5)	0.233	53 (50)	34 (49.3)	0.925
Age, y	60.70 ± 13.79	60.08 ± 13.84	0.704	60.94 ± 15.60	61.39 ± 16.10	0.874	60.48 ± 11.90	59.64 ± 12.11	0.650
BMI, kg/m²	24.53 ± 4.29	24.26 ± 3.48	0.566	27.01 ± 4.22	26.74 ± 2.84	0.696	22.19 ± 2.79	22.83 ± 2.99	0.157
ALT, U/L	26.71 ± 21.78	23.97 ± 15.29	0.243	29.82 ± 17.00	30.23 ± 19.41	0.900	23.77 ± 25.21	19.82 ± 9.90	0.217
AST, U/L	23.68 ± 11.74	23.23 ± 10.92	0.738	24.12 ± 8.60	24.46 ± 10.02	0.836	23.27 ± 14.11	22.28 ± 11.24	0.623
GGT, U/L	36.53 ± 37.60	29.64 ± 20.11	0.035	41.06 ± 27.28	36.08 ± 24.46	0.304	32.26 ± 44.95	25.42 ± 15.25	0.151
ALP, U/L	73.09 ± 20.44	71.19 ± 23.03	0.452	71.59 ± 15.08	69.60 ± 20.09	0.516	74.51 ± 24.43	72.58 ± 24.46	0.611
TG, mmol/L	1.65 ± 1.17	1.49 ± 0.91	0.233	1.95 ± 1.35	1.83 ± 1.21	0.609	1.36 ± 0.87	1.28 ± 0.54	0.515
TC, mmol/L	4.71 ± 1.39	4.94 ± 1.78	0.142	5.44 ± 0.82	5.54 ± 0.84	0.535	4.57 ± 1.20	4.03 ± 1.47	0.008
HDL, mmol/L	1.26 ± 0.29	1.25 ± 0.35	0.721	1.20 ± 0.20	1.19 ± 0.24	0.923	1.32 ± 0.34	1.27 ± 0.40	0.376
LDL, mmol/L	3.17 ± 0.65	2.94 ± 0.72	0.003	3.23 ± 0.51	2.88 ± 0.54	0.056	3.12 ± 0.76	3.08 ± 0.59	0.705
TBIL, umol/L	12.90 ± 4.67	13.55 ± 5.47	0.268	12.72 ± 4.39	14.16 ± 5.18	0.092	13.06 ± 4.94	13.20 ± 5.56	0.860
FPG, mmol/L	5.16 ± 1.67	4.94 ± 1.18	0.225	5.74 ± 2.12	5.35 ± 1.37	0.272	4.61 ± 0.77	4.67 ± 0.94	0.656

Abbreviations: BMI body mass index, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT γ-glutamyltransferase, ALP alkaline phosphatase, TG triglyceride, TC total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein, TBIL total bilirubin, FPG fasting plasma glucose, NAFLD nonalcoholic fatty liver disease
^aValues are expressed as mean ± SD and compared by Student’s t-test

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