|
Parameter
|
Total
|
APOE subgroup
|
P value
|
|---|
|
E2
|
E3
|
E4
|
|---|
|
APOE
|
4.08 ± 1.27
|
4.94 ± 1.47
|
4.00 ± 1.15
|
3.34 ± 0.80
|
< 0.001*
|
|
APOE-HDL
|
1.45 ± 0.60
|
2.08 ± 1.15
|
1.38 ± 0.50
|
0.90 ± 0.34
|
< 0.001**
|
|
APOE-non-HDL
|
2.66 ± 0.93
|
2.86 ± 1.15
|
2.64 ± 0.92
|
2.44 ± 0.66
|
0.43
|
|
APOE-IDL + LDL
|
2.06 ± 0.85
|
2.23 ± 1.25
|
2.09 ± 0.72
|
1.70 ± 0.62
|
0.23
|
|
APOE-VLDL
|
0.57 ± 0.42
|
0.63 ± 0.52
|
0.51 ± 0.37
|
0.70 ± 0.44
|
0.23
|
|
APOAI
|
168 ± 30
|
178 ± 33
|
166 ± 30
|
164 ± 25
|
0.49
|
|
APOE-HDL/APOAI
|
0.0086 ± 0.0031
|
0.0117 ± 0.0019
|
0.0082 ± 0.0027
|
0.0056 ± 0.0023
|
< 0.0001***
|
|
APOB
|
94 ± 25
|
91 ± 11
|
95 ± 27
|
97 ± 30
|
0.95
|
|
APOB-IDL + LDL
|
85 ± 24
|
81 ± 12
|
85 ± 25
|
87 ± 37
|
0.97
|
|
APOB-VLDL
|
8.8 ± 4.2
|
9.4 ± 4.2
|
8.1 ± 4.0
|
10.7 ± 4.4
|
0.08
|
|
APOE/APOB in non-HDL
|
0.029 ± 0.0085
|
0.032 ± 0.012
|
0.029 ± 0.0074
|
0.026 ± 0.0068
|
0.40
|
|
APOE/APOB in IDL + LDL
|
0.025 ± 0.010
|
0.028 ± 0.015
|
0.025 ± 0.0082
|
0.021 ± 0.0073
|
0.15
|
|
APOE/APOB in VLDL
|
0.071 ± 0.044
|
0.070 ± 0.046
|
0.071 ± 0.044
|
0.073 ± 0.045
|
0.95
|
- Values are presented as mean ± SD. Differences among the subgroups were analysed using ANOVA and test post hoc Tukey’s test
- APOE - apolipoprotein E, APOAI - apolipoprotein AI, APOB - apolipoprotein B, non-HDL - non-high density lipoprotein (VLDL + IDL + LDL), HDL - high density lipoprotein, VLDL - very low-density lipoprotein, IDL - intermediate density lipoprotein, LDL - low density lipoprotein
- Subgroups: E2: ɛ2ɛ3 subjects; E3: ɛ3ɛ3 subjects; E4: ɛ3ɛ4 subjects
- * E2 vs E4 p = 0.002, E2 vs E3 p = 0.052, E3 vs E4 p = 0.291, ** E2 vs E4 p < 0.001, E2 vs E3 p < 0.001, E3 vs E4 p = 0.039, *** E2 vs E4 p < 0.001, E2 vs E3 p < 0.001, E3 vs E4 p = 0.016
