Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis

Xu, Jin-Jian; Liu, Ke-Qi; Ying, Zhi-Min; Zhu, Xiao-Wei; Xu, Xue-Jin; Zhao, Pian-Pian; Bai, Wei-Yang; Qiu, Mo-Chang; Zhang, Xing-Wei; Zheng, Hou-Feng

doi:10.1186/s12944-019-1018-3

Lipids in Health and Disease

Table 1 The basic information of every studies included in this meta-analysis

From: Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis

Polymorphisms	Study	Year	Ethnicity	design	Endpoint	P(HWE)	Sample size		Genotypes						Allele frequencies (%)
Polymorphisms	Study	Year	Ethnicity	design	Endpoint	P(HWE)	Cases	Controls	Cases			Controls			Cases		Controls
									CC	CT	TT	CC	CT	TT	C	T	C	T
rs2569190 (C-260T)	Wei et al. [40]	2006	East Asian	CC	CHD	0.22	246	258	58	112	76	83	118	57	46.3	53.7	55.0	45.0
	Zhang et al. [18]	2006	East Asian	CC	CHD	0.05	193	225	20	95	78	39	92	94	35.0	65.0	37.8	62.2
	Li et al. [41]	2007	East Asian	CC	CHD	0.14	193	225	29	95	69	47	124	54	40.0	60.0	48.0	52.0
	Xie et al. [42]	2008	East Asian	CC	CHD	0.24	241	149	49	127	65	56	65	28	46.7	53.3	59.4	40.6
	Liu et al. [55]	2010	East Asian	CC	AMI	0.19	12O	130	23	56	41	43	57	30	42.5	57.5	55.0	45.0
	Shimada et al. [43]	2000	East Asian	CC	MI	0.83	128	83	27	49	52	21	43	19	40.0	60.0	51.0	49.0
	Hohda et al. [44]	2003	East Asian	CC	MI	0.2	502	527	97	242	163	115	278	134	43.4	56.6	48.2	51.8
	Nauck et al. [16]	2002	European	NCC	AMI	0.43	2559	697	675	1262	622	188	358	151	51.0	49.0	53.0	47.0
	Nauck et al. [16]	2002	European	NCC	MI	0.43	1599	697	444	758	397	188	358	151	51.0	49.0	53.0	47.0
	Unkelbach et al. [19]	1999	European	CC	MI	0.99	1053	1175	292	520	241	339	584	252	52.0	48.0	54.0	46.0
	Koenig et al. [45]	2002	European	CC	AMI	0.62	312	476	75	164	73	126	243	107	50.3	49.7	52.0	48.0
	Longobardo et al. [46]	2003	European	CC	AMI	0.38	215	215	44	101	70	55	101	59	44.0	56.0	49.0	51.0
	Morange et al. [47]	2005	European	CC	MI	0.38	194	197	42	98	54	39	104	54	47.0	53.0	46.0	54.0
	Giacconi et al. [48]	2007	European	CC	CHD	0.14	146	148	39	69	38	48	80	20	50.4	49.6	59.0	41.0
	Hubacek et al. [15]	1999	European	CC	MI	0.11	178	135	52	77	49	61	53	21	50.8	49.2	64.8	35.2
	Lorenzova et al. [49]	2007	European	CC	AMI	0.32	230	562	63	116	51	166	268	128	53.0	47.0	53.0	47.0
	Arroyo-Espliguro [50]	2005	European	CC	AMI	0.35	194	94	45	85	64	31	42	21	45.1	54.9	55.3	44.7
	Arroyo-Espliguro [50]	2005	European	CC	CHD	0.35	140	94	34	78	28	31	42	21	52.1	47.9	55.3	44.7
	Morange et al. [47]	2005	European	CC	MI	0.41	54	70	12	28	14	24	31	15	48.0	52.0	56.0	44.0
	Morange et al. [47]	2005	European	CC	MI	0.19	99	121	20	57	22	29	53	39	49.0	51.0	46.0	54.0
	Morange et al. [51]	2004	European	NCC	MI	0.09	128	253	43	59	26	69	113	71	57.0	43.0	50.0	50.0
	Morange et al. [51]	2004	European	NCC	CHD	0.75	123	243	31	58	34	61	124	58	49.0	51.0	51.0	49.0
	Morange et al. [47]	2005	European	CC	MI	0.2	179	176	60	94	25	65	77	34	60.0	40.0	59.0	41.0
	Zee et al. [52]	2001	America	NCC	MI	0.99	387	387	98	215	74	108	193	86	53.0	47.0	53.0	47.0
C-159T	Jin et al. [23]	2016	East Asian	CC	EH-LVH	0.99	116	108	27	58	31	25	54	29	48.3	51.7	48.3	51.7
	Jin et al. [23]	2016	East Asian	CC	EH-NLVH	0.99	107	108	24	46	37	25	54	29	43.8	56.2	48.3	51.7
	Jin et al. [23]	2016	East Asian	CC	EH-LVH	1	103	108	23	52	28	26	54	28	47.6	52.4	49.1	50.9
	Jin et al. [23]	2016	East Asian	CC	EH-NLVH	1	100	108	23	44	33	26	54	28	45.0	55.0	49.1	50.9
	Wei et al. [40]	2006	East Asian	CC	CHD	0.09	246	258	47	128	71	39	139	80	45.1	54.9	42.1	57.9
	Li et al. [22]	2005	East Asian	CC	CHD	0.2	162	196	24	75	63	54	89	53	38.0	62.0	59.2	40.8
	Haberbosch et al. [21]	2009	European	CC	AMI	0.46	54	252	16	24	14	71	131	50	51.9	48.1	54.2	45.8
	Haberbosch et al. [21]	2009	European	CC	MI	0.46	146	252	50	69	27	71	131	50	57.9	42.1	54.2	45.8
	Koch et al. [20]	2002	European	CC	AMI	0.43	998	340	273	498	227	88	177	75	52.0	48.0	52.0	48.0
	Koch et al. [20]	2002	European	CC	MI	0.43	793	340	232	390	171	88	177	75	54.0	46.0	52.0	48.0
	Unkelbach et al. [19]	1999	European	CC	AMI	0.36	1727	501	491	864	372	140	240	121	53.0	47.0	52.0	48.0
	Damiano et al. [53]	2012	European	CC	CHD	0.07	51	49	7	23	21	13	18	18	36.0	64.0	44.0	56.0
	Banerjee et al. [54]	2009	Indian	CC	AMI	0.14	210	232	45	116	49	38	126	68	49.0	51.0	44.0	56.0

CHD coronary heart disease, AMI acute myocardial infarction, MI myocardial infarction, EH –LVH/ EH –LVH essential hypertension with left/not left ventricular hypertrophy, CC case–control, NCC nested case–control, Endpoint diseases of cases, HWE Hardy-Weinberg Equilibrium

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