Table 2 Meta-analysis of the association between rs2569190 (C-260T) polymorphism and CVD risk
From: Effect of CD14 polymorphisms on the risk of cardiovascular disease: evidence from a meta-analysis
Sub-group analysis | No of data sets | No of cases/controls | Allele model (T VS.C) | Dominant model (CC VS.TT + CT) | Recessive model (TT VS.CC + CT) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | OR (95% CI) | POR | PH | OR (95% CI) | POR | PH | OR (95% CI) | POR | PH | ||
Overall | 24 | 9413 | 7337 | 1.169(1.087–1.257) | 2.44 × 10−5* | 0.001 | 1.233(1.110–1.370) | 3.79 × 10−5* | 0.02 | 1.195(1.062–1.345) | 0.003* | 0.002 |
Ethnicity | ||||||||||||
 East Asian | 7 | 1503 | 1597 | 1.370(1.226–1.531) | 2.86 × 10−8* | 0.308 | 1.574(1.278–1.938) | 9.11 × 10−7* | 0.217 | 1.492(1.236–1.801) | 3.05 × 10−5* | 0.22 |
 European | 16 | 7403 | 5353 | 1.100(1.019–1.189) | 0.015 | 0.047 | 1.113(1.006–1.232) | 0.039 | 0.237 | 1.112(0.975–1.269) | 0.113 | 0.04 |
 America | 1 | 387 | 387 | 1.000(0.819–1.221) | 1 | – | 1.142(0.830–1.571) | 0.416 | – | 0.827(0.584–1.173) | 0.287 | – |
Endpoint | ||||||||||||
 CHD | 7 | 1019 | 1005 | 1.357(1.157–1.592) | 2.47 × 10−7* | 0.074 | 1.669(1.388–2.007) | 2.48 × 10−6* | 0.433 | 1.342(1.011–1.781) | 0.042 | 0.035 |
 AMI | 7 | 762 | 1244 | 1.152(1.036–1.281) | 0.009 | 0.143 | 1.186(0.997–1.412) | 0.054 | 0.131 | 1.162(1.030–1.310) | 0.015 | 0.483 |
 MI | 10 | 4641 | 3915 | 1.077(0.976–1.188) | 0.139 | 0.072 | 1.061(0.949–1.186) | 0.297 | 0.799 | 1.118(0.907–1.378) | 0.297 | 0.002 |