From: Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002
Telomere length (R/S ratio) | Q1 | Q2 | Q3 | Q4 | P value |
---|---|---|---|---|---|
n | 1617 | 1617 | 1617 | 1617 | |
lipoprotein | |||||
LDL-C, mean ± SD (mg/dL) | 128.66 ± 32.64 | 125.47 ± 33.47 | 120.82 ± 33.24 | 120.14 ± 34.41 | < 0.0001 |
HDL-C, mean ± SD (mg/dL) | 50.27 ± 14.85 | 50.67 ± 16.01 | 50.95 ± 15.26 | 51.42 ± 15.02 | 0.1641 |
Triglycerides, mean ± SD (mg/dL) | 159.05 ± 136.78 | 145.78 ± 106.29 | 146.08 ± 153.61 | 129.76 ± 101.80 | < 0.0001 |
Sociodemographic variables | |||||
Age, mean ± SD (years) | 54.54 ± 16.91 | 46.34 ± 15.34 | 41.57 ± 14.67 | 37.37 ± 13.04 | < 0.0001 |
Poverty to income ratio, mean ± SD (years) | 0.75 ± 0.08 | 0.93 ± 0.04 | 1.09 ± 0.05 | 1.40 ± 0.25 | < 0.0001 |
Sex (%) | 0.2236 | ||||
male | 51.04 | 49.18 | 47.37 | 49.19 | |
female | 48.96 | 50.82 | 52.63 | 50.81 | |
Race/Ethnicity (%) | < 0.0001 | ||||
Mexican American | 7.01 | 7.84 | 8.90 | 6.70 | |
Non-Hispanic Black | 7.94 | 8.51 | 9.55 | 12.92 | |
Non-Hispanic White | 75.75 | 73.36 | 69.74 | 66.70 | |
Other Hispanic | 6.07 | 6.36 | 6.69 | 9.37 | |
Other race/ethnicity | 3.24 | 3.93 | 5.13 | 4.31 | |
Education (%) | < 0.0001 | ||||
less than high schoo | 27.77 | 21.22 | 20.97 | 17.70 | |
high school | 25.76 | 26.44 | 24.83 | 26.27 | |
more than high school | 46.48 | 52.34 | 54.20 | 56.03 | |
Martial Status (%) | < 0.0001 | ||||
married | 71.65 | 65.36 | 60.13 | 53.23 | |
single | 23.25 | 28.38 | 34.21 | 39.37 | |
living with partner | 5.10 | 6.27 | 5.66 | 7.40 | |
Variables of laboratory data | |||||
ALT, mean ± SD (U/L) | 26.38 ± 20.63 | 26.61 ± 21.67 | 26.68 ± 56.22 | 26.18 ± 27.74 | 0.9715 |
AST, mean ± SD(U/L) | 25.68 ± 20.19 | 24.26 ± 12.58 | 23.66 ± 11.28 | 24.65 ± 22.67 | 0.0096 |
Blood urea nitrogen, mean ± SD (mg/dL) | 15.14 ± 6.26 | 13.74 ± 4.68 | 13.34 ± 5.05 | 13.11 ± 4.44 | < 0.0001 |
Creatinine, mean ± SD(mg/dL) | 0.86 ± 0.49 | 0.83 ± 0.43 | 0.82 ± 0.39 | 0.80 ± 0.28 | 0.0003 |
C-reactive protein(mg/dL) | 0.51 ± 0.88 | 0.43 ± 0.83 | 0.40 ± 0.65 | 0.33 ± 0.56 | < 0.0001 |
Uric acid, mean ± SD(mg/dL) | 5.52 ± 1.51 | 5.32 ± 1.41 | 5.29 ± 1.48 | 5.26 ± 1.46 | < 0.0001 |
Medical examination and personal life history | |||||
Body Mass Index, mean ± SD (kg/m2) | 28.67 ± 6.09 | 28.25 ± 6.27 | 27.78 ± 6.14 | 27.42 ± 6.25 | < 0.0001 |
Physical Activity (MET-based rank) (%) | < 0.0001 | ||||
Sits | 26.29 | 19.47 | 19.37 | 18.22 | |
Walks | 27.42 | 29.48 | 25.63 | 27.99 | |
Light loads | 18.92 | 18.84 | 19.68 | 19.08 | |
Heavy work | 27.36 | 32.21 | 35.31 | 34.72 | |
Current or Past Cigarette Smoker (%) | < 0.0001 | ||||
none | 47.76 | 47.87 | 53.41 | 53.81 | |
current | 30.24 | 26.73 | 21.59 | 19.15 | |
past | 22.00 | 25.40 | 25.00 | 27.04 | |
Dietary interview - individual foods | |||||
Alcohol, mean ± SD (gm) | 9.31 ± 36.24 | 10.49 ± 30.58 | 11.41 ± 32.26 | 15.07 ± 46.08 | < 0.0001 |
Caffeine, mean ± SD (mg) | 220.92 ± 276.11 | 233.16 ± 325.75 | 190.05 ± 226.56 | 179.96 ± 250.56 | < 0.0001 |
Calcium, mean ± SD (mg) | 832.32 ± 681.72 | 847.10 ± 551.24 | 881.93 ± 613.60 | 901.43 ± 642.76 | 0.0053 |
Carbohydrate, mean ± SD (gm) | 258.16 ± 141.13 | 275.16 ± 136.13 | 281.59 ± 128.51 | 295.30 ± 142.53 | < 0.0001 |
Cholesterol, mean ± SD (mg) | 274.05 ± 242.38 | 297.85 ± 242.96 | 298.35 ± 254.11 | 293.91 ± 234.86 | 0.0191 |
Dietary fiber, mean ± SD (gm) | 15.86 ± 11.70 | 15.71 ± 9.86 | 15.61 ± 9.61 | 16.14 ± 10.66 | 0.4535 |
Energy, mean ± SD (kcal) | 2084.67 ± 1023.12 | 2241.17 ± 1039.35 | 2272.85 ± 1018.07 | 2367.07 ± 1085.04 | < 0.0001 |
Total monounsaturated fatty acids, mean ± SD (gm) | 29.81 ± 18.42 | 32.12 ± 20.16 | 31.56 ± 19.47 | 32.15 ± 19.17 | 0.0021 |
Total polyunsaturated fatty acids, mean ± SD (gm) | 16.14 ± 10.83 | 17.65 ± 12.43 | 17.04 ± 11.51 | 17.39 ± 11.84 | 0.0024 |
Total saturated fatty acids, mean ± SD (gm) | 25.88 ± 17.18 | 27.99 ± 16.81 | 28.04 ± 18.00 | 28.32 ± 17.37 | 0.0003 |
Total fat, mean ± SD (gm) | 79.32 ± 46.23 | 86.01 ± 49.33 | 84.40 ± 48.42 | 85.63 ± 48.05 | 0.0003 |
Comorbidities (%) | |||||
Any Diabetes (FBG > = 126 mg/dL or self-report) | < 0.0001 | ||||
No | 89.27 | 93.06 | 93.87 | 95.14 | |
Yes | 10.73 | 6.94 | 6.13 | 4.86 | |
Any Hypertension (BP > = 139/90 or self report) | < 0.0001 | ||||
No | 66.69 | 76.41 | 77.14 | 82.74 | |
Yes | 33.31 | 23.59 | 22.86 | 17.26 | |
Any CAD (self report) | < 0.0001 | ||||
No | 94.80 | 97.14 | 98.13 | 98.85 | |
Yes | 5.20 | 2.86 | 1.87 | 1.15 | |
Any family with heart attack or angina | < 0.0001 | ||||
No | 67.61 | 65.43 | 60.84 | 59.47 | |
Yes | 32.39 | 34.57 | 39.16 | 40.53 |