Table 2 Association of mean Telomere Length with lipoproteins
From: Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002
Exposure | Model1 β (95% CI) | Model 2 βa (95% CI) | Model 3 βa (95% CI) | GAM model βa (95% CI) |
|---|---|---|---|---|
LDL-cholesterol (mg/dL) (n = 3042) | ||||
Telomere length (per 0.1 change) | −1.18 (−1.62, − 0.75) | − 0.01 (− 0.48, 0.45) | 0.18 (−0.26, 0.68) | 0.07 (− 0.35, 0.59) |
Telomere length (per 0.1 change)(quartile) | ||||
Q1 | ref | ref | ref | ref |
Q2 | −3.19 (−6.63, 0.25) | 0.32 (−3.07, 3.71) | 0.02 (−3.32, 3.36) | −0.96 (−4.26, 2.34) |
Q3 | −7.85 (−11.29, −4.40) | − 1.36 (−4.85, 2.14) | −0.87 (− 4.31, 2.58) | −1.28 (− 4.66, 2.11) |
Q4 | −8.52 (− 11.93, −5.12) | −0.16 (− 3.74, 3.41) | 0.81 (−2.72, 4.33) | −0.09 (− 3.59, 3.40) |
P for trend | < 0.0001 | 0.930 | 0.622 | 0.873 |
Triglycerides (mg/dL) (n = 6461) | ||||
Telomere length (per 0.1 change) | − 3.52 (− 4.59, − 2.46) | − 1.56 (− 2.68,-0.44) | − 0.98 (− 2.06, 0.10) | − 0.81 (− 1.74, 0.29) |
Telomere length (per 0.1 change)(quartile) | ||||
Q1 | ref | ref | ref | ref |
Q2 | − 13.27 (− 22.02, − 4.52) | − 5.12 (− 13.87, 3.63) | −2.64 (− 11.05, 5.77) | −4.78 (− 12.98, 3.42) |
Q3 | −12.97 (− 21.64, − 4.30) | − 0.46 (− 9.36, 8.43) | 1.46 (−7.10, 10.02) | − 0.12 (− 8.48, 8.23) |
Q4 | −29.28 (− 37.80, − 20.76) | −13.06 (− 22.11, − 4.01) | −8.95 (− 17.66, − 0.23) | −8.19 (− 16.69, 0.31 |
P for trend | < 0.0001 | 0.013 | 0.117 | 0.082 |
HDL-Cholesterol (mg/dL) (n = 6461) | ||||
Telomere length (per 0.1 change) | 0.16 (0.03, 0.29) | 0.33 (0.20, 0.46) | 0.19 (0.03, 0.37) | 0.13 (0.01, 0.33) |
Telomere length (per 0.1 change)(quartile) | ||||
Q1 | ref | ref | ref | ref |
Q2 | 0.41 (− 0.66, 1.47) | 0.93 (− 0.07, 1.94) | 0.50 (− 0.42, 1.42) | 0.24 (− 0.65, 1.13) |
Q3 | 0.68 (− 0.37, 1.74) | 1.49 (0.47, 2.51) | 0.95 (0.01, 1.89) | 0.79 (− 0.11, 1.70) |
Q4 | 1.15 (0.11, 2.19) | 2.60 (1.56, 3.64) | 1.48 (0.53, 2.44) | 1.15 (0.23, 2.08 |
P for trend | 0.0245 | < 0.001 | 0.001 | 0.023 |