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Table 3 Univariate and multivariate Cox hazards regression analysis of CAD

From: Integrated analysis of gene expression changes associated with coronary artery disease

Parameter

Univariate

HR (95% CI)

P-value

Multivariate

HR (95% CI)

P-value

Age

1.003(0.984–1.022)

0.766

1.006(0.979–1.034)

0.660

Sex

 Male

1

–

1

–

 Female

0.645(0.137–1.311)

0.225

0.442(0.145–1.351)

0.152

Cigarette Smoking

 No

1

–

1

–

 Yes

1.506(0.831–2.727)

0.011

1.910(0.699–5.222)

0.020

Alcohol Drinking

 No

1

–

1

–

 Yes

0.507(0.319–1.772)

0.043

0.986(0.580–2.805)

0.094

Dyslipidemia

 No

1

–

1

–

 Yes

1.959(1.557–2.651)

0.023

1.831(1.375–2.842)

0.064

Hypertension

 No

1

–

1

–

 Yes

1.914(1.085–3.375)

0.025

1.187(0.622–2.264)

0.060

Diabetes Mellitus

 No

1

–

1

–

 Yes

1.970(1.103–3.518)

0.022

3.679(1.634–8.283)

0.002

IL1B

1.945(1.829–2.077)

0.009

1.896(1.435–2.845)

0.017

ICAM1

1.328(1.218–1.493)

0.087

1.134(1.010–2.758)

0.126

JUN

1.480(1.362–1.638)

0.059

1.528(1.270–5.652)

0.083

CCL2

1.945(0.830–2.088)

0.009

1.172(0.563–2.440)

0.032

  1. HR, hazard rate; CI, confidence interval; IL1B, interleukin 1 beta; ICAM1, intercellular adhesion molecule 1; JUN, Jun proto-oncogene; CCL2, C-C motif chemokine ligand 2