Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults

Table 2 Associations* of plasma metabolites with obesity (n = 300)

Metabolite†	β	SE	p-Value^‡	R²
Ala	0.174	0.033	3.66E-07	0.139
Asn	−0.080	0.023	4.57 E-04	0.074
Glu	0.266	0.025	6.96E-23	0.479
Ile	0.182	0.027	4.97E-11	0.379
Leu	0.119	0.022	1.63E-07	0.438
Pro	0.164	0.040	6.47E-05	0.130
Ser	−0.106	0.027	1.41 E-04	0.176
Tyr	0.161	0.026	1.44E-09	0.258
Val	0.134	0.021	4.82E-10	0.375
LPCa C16:1	0.154	0.038	8.21E-05	0.081
LPCa C18:1	−0.123	0.030	4.96E-05	0.098
LPCa C18:2	−0.217	0.034	8.51E-10	0.189
LPCe C18:0	−0.208	0.046	9.40E-06	0.124
PCaa C32:1	0.365	0.065	5.24E-08	0.178
PCaa C32:2	0.190	0.048	9.71E-05	0.157
PCaa C38:3	0.298	0.055	1.12E-07	0.197
PCae C34:3	−0.130	0.037	4.71 E-04	0.065
PCae C38:4	−0.125	0.035	3.65 E-04	0.088
PCae C40:6	−0.148	0.039	2.20 E-04	0.097

*Adjusted for age (years), sex, total calorie intake (Kcal/day), total physical activity (MET-minutes/week), smoking (cigarettes/day) and alcohol consumption (g/day)
†Metabolites were ln-transformed
‡ p-values were Bonferroni corrected at 0.05/104 metabolites = 4.8 × 10⁻⁴
Abbreviations: SE standard error, Ala alanine, Asn asparagine, Glu glutamic acid, Ile isoleucine, Leu leucine, Pro proline, Ser serine, Tyr tyrosine, Val valine, LPCa acyl-lysophosphatidylcholine, LPCe alkyllysophosphatidylcholine, PCaa diacyl-phosphatidylcholine, PCae acyl-alkyl-phosphatidylcholine

ISSN: 1476-511X