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Table 6 Clinical phenotypes of FH patients

From: Effects of familial hypercholesterolemia-associated genes on the phenotype of premature myocardial infarction

 

FH patients (n = 19)

Non-FH patients (n = 206)

P value

Male, n(%)

17 (89.5)

171 (83.0)

0.467

BMI (kg/m2)

27.82 ± 5.28

26.60 ± 3.30

0.334

Age at MI onset (years)

46.68 ± 7.97

50.43 ± 7.91

0.050

Family history of PCHD, n (%)

11 (57.9)

38 (18.4)

< 0.001

eGFR (ml/min/1.73m2)

93.95 (76.40, 101.71)

97.37 (84.17, 104.48)

0.435

LDL-C (mmol/L)

4.93 (4.80, 6.37)

3.58 (2.95, 4.21)

< 0.001

LVEF (%)

61.31 ± 12.22

60.90 ± 10.08

0.869

Gensini scores

62 (48, 92)

53.5 (32, 77.25)

0.087

Tendon xanthoma/corneal arcus n(%)

0 (0)

0 (0)

1.000

Multivessel lesion, n(%)

15 (78.9)

161 (78.2)

0.936

Smoking, n (%)

17 (89.5)

136 (66.0)

0.036

Hyperlipemia, n (%)

11 (57.9)

64 (31.1)

0.018

Hypertension, n (%)

4 (21.1)

112 (54.4)

0.005

Diabetes, n (%)

7 (36.8)

76 (36.9)

0.996

  1. FH familial hypercholesterolemia, LDL-C low-density lipoprotein cholesterol, BMI body mass index, LVEF left ventricular ejection fraction. All P values represent comparisons between PMI patients and non-PMI patients. Comparisons between groups were performed with student’s t-test for continuous variables and with Chi-square test for categorical variables. P < 0.05 was considered statistically significant