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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Role of ω3 polyunsaturated fatty acids in diabetic retinopathy: a morphological and metabolically cross talk among blood retina barriers damage, autoimmunity and chronic inflammation

Fig. 4

Human retina of diabetic patient with advanced DMRP. This picture illustrating layers 1 and 2 as identified in Fig. 1. Also compare with Fig. 2. Microhemorrhage (indicated with a black square, ■) from heavily congested bv pouring out rb and inflammatory cells within augmented perivascular collageno-genesis in ct interstitium. Cystoid degeneration (CD) appears as enlarged and coalescent bubbles arising within IC containing coarse bundles of intermediate filaments (if). Thickened Bruch membrane bordering the vitreous body and BMs of bv are characteristic features of DMRP diapedesis of inflammatory cells (polynuclears, lymphocytes) and wandering plasmocytes are pointed (arrows). Swollen mitochondria are frequently seen in axolemma of the layer 2 of axons of ganglion neurons and cytoplasmic projections of Müller glial cells overloaded with coarse bundles o neurofilaments some of them invading the lumen of bv through damaged BMs (indicated with a black circle, ) whereas others are deeply anchored within Bruch membrane. Incontinent or damaged ZO and ZA are shown. Apoptotic Müller cell nucleus (indicated with a black triangle, ▲)

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