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Fig. 5 | Lipids in Health and Disease

Fig. 5

From: Role of ω3 polyunsaturated fatty acids in diabetic retinopathy: a morphological and metabolically cross talk among blood retina barriers damage, autoimmunity and chronic inflammation

Fig. 5

Higher magnification of the layers 9 to 11 plus CC of human retina of diabetic patient with advanced DMRP; as identified in Fig. 1. Also compare with Fig. 3. Congested bv in CC layer showing increased perivascular collagen genesis in coarse ct interstitium. Thickening of Bruch basal membrane (indicated with a black triangle,▼) bordering against CC layer and BMs of bv are characteristic features of DMRP at this stage. Diapedesis of inflammatory cells (polynuclears, lymphocytes) from bv and wandering plasmocytes are pointed (arrow). There are scarce pericytes some of them in apoptosis (apoptotic cells were indicated with a black diamond, ♦). Swollen mitochondria and vesicles of SER are frequently seen in cytoplasm of PEC, whose nuclei are in diverse stages of apoptosis. Incontinent or damaged ZO, ZA are identified thus facilitating the development of large PEC intercellular vacuoles (*) which in turns collaborate in the worsening of retinal edema. Few rods and cones inner segments (RCIS) are visible, most of them degenerated and vacuolated. Closer PEC recesses are filled with increased number of lyso-phagosomes (lf) and myelin like figures (indicated with a filled black arrow) containing aged sacs membranes in diverse stages of digestion

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Lipids in Health and Disease

ISSN: 1476-511X