Skip to main content

Table 3 Effect of Doxorubicin (DOX) and different treatments of AHE on hepatic phase II antioxidant enzymes and GSH profile

From: Effect of Acacia hydaspica R. Parker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats

Treatment (mg/kg)

GSH (μM/g tissue)

GR (nM/min/mg protein)

GST (nM/min/mg protein)

γ-GT (nM/min/mg Protein)

GPx (nM/min/mg Protein)

Control

19.61 ± 0.283b

163.6 ± 0.656b

142.6 ± 0.57b

336.2 ± 0.564b

139.5 ± 1.164b

DOX

10.46 ± 0.660a

101.4 ± 0.599a

99.72 ± 1.08a

141.6 ± 0.296a

92.58 ± 0.752a

AHE alone

20.11 ± 0.158b

164.2 ± 0.677b

142.7 ± 0.89b

336.3 ± 0.999b

139.8 ± 0.355b

DOX + AHE (200)

12.50 ± 0.397a, d

134.8 ± 0.81a, b, d

118.7 ± 1.81a, b, d*

199.2 ± 1.610a, b, d

111.3 ± 0.874a, b, d

DOX + AHE (400)

17.43 ± 0.599a*, b, c

149.8 ± 0.91a, b, c

130.8 ± 1.86a**, b, c**

306.8 ± 0.779a, b, c

130.5 ± 1.192a, b, c

DOX + Sily

17.32 ± 0.387a*, b

152.7 ± 1.671a, b

128.3 ± 2.82a, b

307.9 ± 1.246a, b

130.9 ± 0.344a, b

  1. Values expressed as mean ± SEM. a Significance at p < 0.0001 Vs. control group, b Significance at p < 0.0001 Vs. Doxorubicin (DOX) group, c Significance at p < 0.0001 of DOX + AHE 400 mg/kg group Vs. DOX + AHE 200 mg/kg group. d Significance at p < 0.0001 of AHE co-treatment groups Vs DOX + Sily group. *, ** Significant difference at p < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters. (One way ANOVA followed by Tukey’s multiple comparison tests). Sily-Silymarin