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Table 4 Effect of Doxorubicin (DOX) and different treatments of AHE on liver tissue protein content and oxidative stress markers

From: Effect of Acacia hydaspica R. Parker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats

Treatment (mg/kg) Protein (μg/mg Tissue) H2O2 (nM/min/mg Tissue) Nitrite (content μM/ml) TBARS (nM/min/mg protein)
Control 4.657 ± 0.047b 1.969 ± 0.056b 34.77 ± 1.323b 3.499 ± 0.156b
DOX 1.150 ± 0.049a 5.356 ± 0.074a 90.65 ± 1.787a 9.492 ± 0.427a
AHE alone 4.677 ± 0.149b 1.321 ± 0.057b 36.24 ± 0.958b 3.153 ± 0.087b
DOX + AHE (200) 3.200 ± 0.232a, b, d* 4.039 ± 0.021a, b, d 60.72 ± 2.577a, b, d 6.240 ± 0.589a, b
DOX + AHE (400) 4.128 ± 0.195b, c** 2.319 ± 0.038a**, b, c 43.25 ± 0.485a*, b, c 4.446 ± 0.217b, c*
DOX + Sily 3.985 ± 0.074b 2.336 ± 0.062a**, b 41.32 ± 1.194b 4.829 ± 0.067b
  1. Values expressed as mean ± SEM. a Significance at p < 0.0001 Vs. control group, b Significance at p < 0.0001 Vs. Doxorubicin (DOX) group, c Significance at p < 0.0001 of DOX + AHE 400 mg/kg group Vs. DOX + AHE 200 mg/kg group. d Significance at p < 0.0001 of AHE co-treatment groups Vs DOX + Sily group. *, ** Significant difference at p < 0.05 and p < 0.001 respectively. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters. (One way ANOVA followed by Tukey’s multiple comparison tests). Sily-Silymarin