Skip to main content

Advertisement

Table 1 Characteristics of the 28 clinical trials

From: Statins significantly reduce mortality in patients receiving clopidogrel without affecting platelet activation and aggregation: a systematic review and meta-analysis

Study Year Study design Sample size Population Intervention (mg/d) Mean follow-up End-points NOS score
Lofti et al. [20] 2008 RCT 4162 ACS G1: A80 + Clo G2: P40 + Clo 2 years Death, MI, UA, stroke
Malmstrom et al. [21] 2009 RCT 69 CAD PCI G1: R10–40 + Clo G2: A20–80 + Clo G3: S40 + Clo 16 weeks PA, P-selectin, fibrinogen binding
Mitsios et al. [22] 2004 RCT 45 ACS G1: A10 + Clo G2: P40 + Clo 5 weeks PA, P-selectin, CD40L, lipids, ALT, AST, LDH, CK
Neubauer et al. [10] 2003 Prospective cohort 47 CAD G1: S10/S20/A20/A40 + Clo G2: Clo 48 h P-selectin 9
Ojeifo et al. [23] 2013 Cohort 4794 ACS G1: Statin + Clo G2: Clo 450 days Cardiovascular death, MI, stroke 7
Park et al. [24] 2016 RCT 3755 PCI G1: CYP3A4 + Clo G2: non-CYP3A4 + Clo 1 month PRU, death, MI, revascularization, stent thrombosis
Poyet et al. [25] 2010 RCT 138 ACS PCI G1: A80 + Clo G2: R20 + Clo 1 month PA, LDL-C, HDL-C, CRP
Schmidt et al. [26] 2012 Cohort 13,001 PCI G1: Statin + Clo G2: Clo 12 months MACE 7
Serebruany et al. [6] 2005 Prospective cohort 75 PCI G1: A10–40 + Clo G2: other statins + Clo G3: Clo 24 h PA, P-selectin, CD40L, CD63, PAC-1 8
Suh et al. [27] 2014 Prospective cohort 556 PCI G1:A20 + Clo G2:R10 + Clo 6 months PRU, lipids, MACE, death, MI, stent thrombosis, ischemic strike, target lesion revascularization 7
Toso et al. [28] 2017 Cohort 1053 ACS PCI G1: Statin + Clo G2: Clo 1 year PRI, MACE, death, Cardiac death, MI, stent thrombosis, stroke 7
Vinholt et al. [29] 2005 Cohort 66 CAD G1: CYP3A4 + Clo G2: non-CYP3A4 + Clo 21 days PA, TC, LDL-C 9
Wenaweser et al. [30] 2010 RCT 101 CAD PCI G1: A40 + Clo G2: F80 + Clo 1 month PA
Wenaweser et al. [31] 2007 RCT 73 PCI G1: A20/P40 + Clo G2:Clo 1 month PA, lipids, CRP
Zhang et al. [32] 2015 RCT 104 NSTE-ACS PCI G1: A20 + Clo G2: Clo 6 months IPA, P-selectin, TBX2, sCD40L
Gorchakova et al. [19] 2004 Cohort 180 CAD PCI G1: A/S + Clo G2: Clo At least 4 weeks Maximal PA, Residual PA, P-selectin, CD61 8
Lim et al. [15] 2005 Prospective cohort 15,693 ACS G1: statin + Clo G2: Clo 6 months Rehospitalization, stroke, revascularization, death 9
Nagavi et al. [33] 2016 Prospective cohort 61 PCI G1: A40 + Clo G2: R40 + Clo G3: Clo 24 h PA 7
Riondino et al. [34] 2009 Cohort 105 PCI G1: A20 + Clo G2: R10 + Clo G3: Clo 3 months PA 8
Trenk et al. [11] 2008 Cohort 1395 PCI G1: A + Clo G2: S + Clo G3: F + Clo G4: P + Clo G5: Clo 1 year RPA, P-selectin, CD63, PAC-1, MACE, death, MI, target lesion reintervention 7
Mitsios et al. [35] 2005 Cohort 51 ACS PCI G1: A + Clo G2: Clo 5 weeks PA, P-selectin, CD40L 7
Mukherjee et al. [36] 2005 Prospective cohort 1651 ACS G1: CYP3A4 + Clo G2: non-CYP3A4 + Clo G3: Clo 6 months death, MI, stroke, MACE 8
Lau et al. [4] 2003 Prospective cohort 44 PCI G1: A + Clo G2: P + Clo G3: Clo 24 h PA 8
Matetzky et al. [37] 2010 Cohort 120 STEMI G1: statin + Clo G2: Clo 72 h PA 9
Brophy et al. [16] 2006 Retrospective cohort 2927 PCI G1: A + Clo G2: Clo 30 days death, MI, UA, repeat revascularizations, stroke, transient ischemic attack 7
Pelliccia et al. [38] 2014 RCT 122 CAD G1: A40 + Clo G2: R20 + Clo 30 days PRU, lipids
J.-M.Lablanche et al. [39] 2010 RCT 753 ACS G1: A80 + Clo G2: R20 + Clo 3 months lipids, MI, stroke, death, UA, repeat revascularization
Guo et al. [40] 2017 RCT 137 ACS PCI G1: R10 + Clo G2: Clo 1 year Restenosis, death, MI, target vessel revacularization
  1. G: group; RCT: randomized controlled trial; ACS: acute coronary syndromes; CAD: coronary artery disease; MI: myocardial infarction; UA: unstable angina; PCI: percutaneous coronary intervention; PA: platelet aggregation; PRU: platelet reactive unit; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TC: total cholesterol; CRP: C-reactive protein; MACE: major adverse cardiovascular events; A: atorvastatin; P: P:pravastatin; R:rosuvastatin; F:fluvastatin; Clo: clopidogrel