Table 2 Summaries for the function of 3 hub genes
From: Identification of biomarkers in macrophages of atherosclerosis by microarray analysis
No. | Gene symbol | Full name | Function |
|---|---|---|---|
1 | KDELR3 | KDEL endoplasmic reticulum protein retention receptor 3 | Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity). |
2 | CD55 | CD55 molecule (Cromer blood group) | This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins |
3 | DYNC2H1 | Dynein cytoplasmic 2 heavy chain 1 | May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). |